Wieczorek Lab
@mike-wieczorek.bsky.social
Structural biology, biophysics and microtubules @ ETH Zurich
Using advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪
Mechanism and regulation of the Bim1 interaction withthe outer kinetochore Ndc80 complex in S. cerevisiae https://www.biorxiv.org/content/10.64898/2026.08.26.747196v1
Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...
A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology
Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...
nature.com
Excited to share what I've been working on with an incredible team! Visualisation of Asgard viruses on cell surfaces and vesicles, and a story of complex viral interactions. Preprint: www.biorxiv.org/content/10.6... @brendanburns999.bsky.social @belindaferrari.bsky.social @xabivc.bsky.social
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
The EMBO Journal@embojournal.org · 3w agoWhat’s the function of embryonic ‘cytoplasmic lattices’? Using cryo-ET, @kashishsingh.bsky.social @carter-lab.bsky.social and coworkers reveal them as megadalton-size hubs of ubiquitination proteins/ubiquitin transfer link.springer.com/article/10.1...
My lab just opened at Lehigh University - we study the origins, mechanisms, and impacts of the rapid evolution of the chromosome segregation machinery. I'm looking for 2 team members (postdoc and lab tech) who are passionate about evolution and cell division! See the opportunities at dudkalab.me.
Dudka Lab — Home
The Dudka Lab at Lehigh University studies how rapid evolution of chromosome segregation machinery impacts health, fertility, and disease.
dudkalab.me
What’s the function of embryonic ‘cytoplasmic lattices’? Using cryo-ET, @kashishsingh.bsky.social @carter-lab.bsky.social and coworkers reveal them as megadalton-size hubs of ubiquitination proteins/ubiquitin transfer link.springer.com/article/10.1...
In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies - The EMBO Journal
Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but ...
link.springer.com
(1/3) For all centrosome/cilia enthusiasts 🗣️🗣️ From Pereira’s lab, we’re so happy to share our latest collab with @sauer-lab.bsky.social: Mega-ExM)! 🥳 Here, we pushed expansion microscopy to crazy scales (1500x 🤯) and used cilia and centrioles as some of our favorite test structures 🤭
Ignacio Vega-Vásquez@igvegvas.bsky.social · 4w ago(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯
We are excited by the publication of our work on Torsin1A, its interaction partner CLCC1, and their role in membrane fusion during NPC biogenesis! A fantastic collaboration with @jagannathan-lab.bsky.social @labvanni.bsky.social @gautamdey.bsky.social and the Korkhov and Antonin labs!
The dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesis
Maslennikova et al. identify the ER membrane protein CLCC1 as an interaction partner of the dystonia-linked AAA+ ATPase Torsin1A. Torsin1A sustains the function of CLCC1, which is proposed to facilitate fusion of the nuclear envelope during NPC biogenesis by forming an oligomer that promotes lipid bilayer approach and remodeling.
cell.com
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b
Some personal news: This September, I’ll be starting the Lange Lab at Weill Cornell Medicine as an Assistant Professor of Biochemistry and Biophysics! We’ll investigate how ubiquitin signals are decoded to control intracellular transport. sven-lange.xyz
Mechanisms of Ubiquitin-Mediated Transport
Lange Lab: Mechanisms of Ubiquitin-Mediated Transport
sven-lange.xyz
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · 4w agoJoin @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b
New lab preprint - Deep learning models are most often difficult to interpret black box models. What if we engineer them with interpretation in mind? Dennis Gankin carefully studied so-called biologically inspired neural networks and found an interesting phenomenon www.biorxiv.org/content/10.6...
Leveraging multiplicity in biologically informed neural networks to uncover disease heterogeneity
Biologically inspired neural networks (BINNs) embed pathway, ontology, or protein-interaction structure directly into neural networks, promising interpretable disease prediction where hidden nodes map...
biorxiv.org
We just preprinted Marianna’s PhD work in which we asked: How does non-coding DNA affect cell physiology? And why do some organisms have so little of it while other genomes are 99% non-coding?
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 2mo agoNon-coding DNA dictates cell size and impairs fitness by sequestering RNA polymerase https://www.biorxiv.org/content/10.64898/2026.07.10.737727v1
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
Excited to share our review article on cilia disassembly, published in @jcellsci.bsky.social. journals.biologists.com/jcs/article/.... We highlight how disassembly of cilia occurs, ...
Primary cilium disassembly – from mechanisms to roles in physiology and disease
Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.
journals.biologists.com
We are recruiting! We invite applications from highly motivated PhD candidates interested in developmental biology, imaging, and in situ structural biology to study the biogenesis and plasticity of motile cilia in development and disease.
He Lab - Our Research
muhelab.com
Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...
Two researchers — one in Massachusetts and one in Shanghai — hoped for the same breakthrough: a gene therapy for deaf children. New Chinese investment in science propelled the one who got there first. n.pr/4weVi49
How the U.S. is losing ground to China in university research
Two researchers — one in Massachusetts and one in Shanghai — hoped for the same breakthrough: a gene therapy for deaf children. New Chinese investment in science propelled the one who got there first.
n.pr
Switzerland and the UK making the most of their participation in the EU research funding initiatives with Switzerland tied with Germany for the largest number of grants in life science.
European Research Council (ERC)@erc.europa.eu · 2mo agoThe results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch
New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863
Structural basis of microtubule destabilization by GTP hydrolysis https://www.biorxiv.org/content/10.64898/2026.06.19.733065v1
Excited to share our Science Advances paper introducing Tether Force Spectroscopy: flow-stretched DNA "sails" that pull on molecules and read out single-molecule behaviour by fluorescence. No beads. Huge thanks to Adam, Ryan and the team. Check out the paper here: www.science.org/doi/10.1126/...
Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!
John Jumper, the lead on Alphafold and Nobel prize winner, is moving from DeepMind to Anthropic. Not a move I would expect but it may signal a strong commitment from Anthropic in further developing their life sciences capabilities.
Reuters@reuters.com · 3mo agoUS scientist John Jumper to leave Google DeepMind for Anthropic reut.rs/3QswiHm
SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules @jojudernatz.bsky.social , @tzviyazbm.bsky.social and colleagues link.springer.com/article/10.1...
SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules - The EMBO Journal
The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrit...
link.springer.com
🚨 I am very happy to share the first preprint from our lab! www.biorxiv.org/content/10.6...
SPACA9 Acts as a Molecular Staple Modulating Microtubule Dynamic Instability
Motile cilia rely on highly stable axonemal microtubules reinforced by microtubule inner proteins (MIPs) that form a network within their lumen, yet the functions of individual MIPs remain poorly unde...
biorxiv.org
