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Ioannis Tsirkas

@ioannistsirkas.bsky.social

Post doc and manga lover, I will be sharing science-related stuff and manga reads.

70 Posts110 Follower323 Folgt
Hasan Yardimci@hyardimci.bsky.social · 3w ago

Delighted to share our latest publication, a collaborative work with @hanasedlackova.bsky.social and @puckknipscheer.bsky.social. Grateful to everyone who contributed to this project. www.cell.com/cell-reports...

FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision

Cameron et al. show that dormant pre-replication complexes are removed upon collision with replication forks in Xenopus egg extracts. They identify FANCJ and RTEL1 as key factors in this process and s...

cell.com

Andrew Deans@genomestability.bsky.social · last mo.

Amazing structures, and distinct binding modes, of TOPBP1 or ETAA1 activating the ATR-ATRIP kinase by an allosteric mechanism. In NSMB from Pavletich lab: www.nature.com/articles/s41...

Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase - Nature Structural & Molecular Biology

Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TO...

nature.com

Nitika Taneja @TanejaLab@nitikataneja.bsky.social · 2mo ago

Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

Marco Fumasoni@marcofumasoni.bsky.social · 3mo ago

Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Marco Fumasoni@marcofumasoni.bsky.social · 9mo ago

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

Timothy Caulfield@caulfieldtim.bsky.social · 3mo ago

Do vaccines save lives? Yep! Does antivaxx BS kill? Yep. 👇 Cervical cancer deaths for vaccinated young women fall to zero in England: study www.ctvnews.ca/health/artic...

Cervical cancer deaths for vaccinated young women fall to zero in England: study

The HPV vaccine for cervical cancer has reduced the risk of dying from the disease before the age of 30 in England to almost zero, the first study of its kind showed Thursday.

ctvnews.ca

Ioannis Tsirkas@ioannistsirkas.bsky.social · 3mo ago

After 9 months of major revisions, 2 out of 3 reviewers were stilll not satisfied, and the editor decided to reject our manuscript. It's been a whole year since we first submitted our paper to a journal, and I am back to timepoint zero 😭😭

Mark Peifer (He, him)@peiferlabunc.bsky.social · 4mo ago

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

Sholto David@sholtodavid.bsky.social · 4mo ago

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!

The EMBO Journal@embojournal.org · 4mo ago

SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers link.springer.com/article/10.1...

SLX4IP limits replication stress globally and at ALT telomeres - The EMBO Journal

Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...

link.springer.com

Sarah McAnulty, Ph.D.@sarahmackattack.bsky.social · 6mo ago

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

ME Torres-Padilla@metorrespadilla.bsky.social · 7mo ago

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

Events for February 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

Kumar Somyajit & Lab@ksomyajit.bsky.social · 7mo ago

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

Wiep Klaas Smits (ExpBac/CMAT)@smitslab.bsky.social · last yr.

DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/10.1128/...

DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology

The regulation of DNA replication is fundamental to cell growth and cell cycle control. In eukaryotes, under-initiation or over-initiation leads to genome instability. In bacteria, it is unclear how c...

journals.asm.org