These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar

Structure and function of the centromere and inner kinetochore

Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...

rdcu.be

@currentbiology.bsky.social has done it again! What a great interview with one of my favorite scientists www.cell.com/current-biol.... Linda Wordeman @mtwonderland.bsky.social. She taught me everything I know about guinea pigs and a lot about mitosis too!

Linda Wordeman

Interview with Linda Wordeman, who studies microtubule dynamics and cell division at the University of Washington School of Medicine.

cell.com

Our flagship conference celebrating everything centrosomes and cilia returns this year and it promises to be another exceptional scientific event in the beautiful city of Lausanne, 1–4 September. 👉 Abstract submission+registration deadline 1 June Don’t miss the opportunity to share your research 🤩

Your cells divided thousands of times today. Most chromosomes landed where they should, but some got stuck. New #RBI research reveals how cells rescue trapped chromosomes during division, and why cancer cells often fail at it. 📄 Published today in @natcomms.nature.com 🔗 doi.org/10.1038/s414...

Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting - Nature Communications

Polar chromosomes in human cells are prone to late alignment and segregation errors. Here, the authors show that spindle elongation rescues them by repositioning astral microtubules via a pivoting mec...

doi.org

New work from my lab, together with Boris Maček's lab! Using magnetic levitation, we made multicellular spheroids to ask a simple question: how different is mitosis in 3D structures compared with standard 2D monolayers? www.biorxiv.org/content/10.6...

1st McKinley Lab grad student’s 1st preprint! @claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy. Come for her GORGEOUS images, stay for her incredible discoveries. www.biorxiv.org/content/10.6... w/ @akelleher1017.bsky.social

Claire Ang@claireang.bsky.social · 5mo ago

Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything. We were wrong. But the real mechanism turned out to be way cooler :) 🧪🧵 www.biorxiv.org/content/10.6...

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

A proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular Biology

Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...

nature.com

3i is hiring a Microscopist - repost & tell a friend! Ideal candidate has experience in fundamental optical theory & familiarity with lightsheet, spinning disk, multiphoton, TIRF etc. Full-time, exempt position (travel to visit customers) offering a competitive salary & comprehensive benefits.

Intelligent Imaging Innovations - Microscopist

Intelligent Imaging Innovations

intelligent-imaging.applicantstack.com

In Memoriam: R. Bruce Nicklas (1932-2025). Leocadia Paliulis commemorates the life of Dr. Nicklas who was a mentor, a polymath with a great sense of humor, and a link to the beginnings of chromosome research. rupress.org/jcb/article/... #CellDivision #Chromosomes

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

Mitosis lovers, get ready for Dubrovnik! 🔬🎉 I’m super excited to be organizing the 4th Mitotic Spindle Conference with Nenad Pavin, and we can’t wait to see you there! Want your abstract to be selected for a talk? Submit by Feb 8! www.phy.pmf.unizg.hr/~mitosis/ #SpindleCroatia2026

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing. We explore this link in our new preprint. 🔗 www.biorxiv.org/content/10.6...

PhD position in my lab!

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.

Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...

Dissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh on FindAPhD.com

PhD Project - Dissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh, listed on FindAPhD.com

findaphd.com

Bungo Akiyoshi@bungoakiyoshi.bsky.social · 12mo ago

My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...

I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...

PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.

The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR

candidate.hr-manager.net

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social www.sciencedirect.com/science/arti...

Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy

Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

sciencedirect.com

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

⚡Ready to grow and be inspired as a scientist? We’re looking for a *PhD student* to join our lab at @crg.eu in Barcelona and explore how cells self-organize, uncovering life’s inner design💡 We offer strong mentoring, cutting-edge science, and a vibrant international team🌍 Check the link below!

Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...

We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo...

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit: NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes Sachin Kotak @spindlebehavior.bsky.social et al www.embopress.org/doi/full/10....

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Computational image analyst (m/f/d)

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

jobs.mpi-muenster.mpg.de

Microtubules: from atoms to complex systems www.embl.org/about/info/c...

Microtubules: from atoms to complex systems

embl.org

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

science.org

The kinetochore corona orchestrates chromosome congression through transient microtubule interactions https://www.biorxiv.org/content/10.1101/2025.09.10.675486v1