Tamra Ogilvie
@tamraogilvie.bsky.social
Professor at Texas Children’s Hospital/Baylor College of Medicine working on medulloblastoma, mom of 2, 🎗️ Childhood cancer, stem cells, alternative splicing, targeted therapies https://www.texaschildrens.org/ogilvie-lab
Happy to share our collaboration with @tamraogilvie.bsky.social !! RBFOX2 restrains oncogenic cell plasticity in Group 3 medulloblastoma Link of the preprint: www.biorxiv.org/content/10.6...
RBFOX2 restrains oncogenic cell plasticity in Group 3 medulloblastoma
Cancer cell plasticity underlies tumor progression, metastasis and therapeutic resistance, yet how RNA-binding proteins regulate malignant state transitions remains poorly defined. Here, we identify t...
biorxiv.org
Delighted to share our latest work @genesdev.bsky.social on cerebellar #organoids as models of #medulloblastoma initiation. Great work of Tom Willott/James Nicholson 🙏🏻 to collaborators/funders in particular Sara Badodi @raduzabet.bsky.social @braintumourrsch.bsky.social @cruk-si.bsky.social
genesdev.cshlp.org
The 3 hardest things to learn as a scientist: 1. Trust the data.. especially when it’s not what you expected, 2. Trust the data.. allowing it to change your direction, 3. Trust the data.. but not too much: test with new data at every turn.
Itai Yanai@itaiyanai.bsky.social · last yr.90% of doing science is being open to new ideas.
A #neuron nucleus once gave me a heart-shaped “I love you back” #FluorescenceFriday ❤️ 5 μm later I’m still not over it. Science isn’t cold—it’s a labor of love. Post your fave “experiment loved me” story? 👇 #Microscopy #BrainLove #ValentinesDay
Some friends and I wrote a review with @biologists.bsky.social !! Together with Esther Becker and Simone Mayer, we explore the state of the cerebellum organoid field and offer practical guidance on getting this model system started in your own lab. journals.biologists.com/dmm/article/...
Generating cerebellar organoids from pluripotent stem cells
Summary: This Special Article provides a comprehensive overview of the methods, applications and considerations for the generation of cerebellar organoids.
journals.biologists.com
Check out our new website and meet the team! www.texaschildrens.org/ogilvie-lab. Thanks to Ben Pakuts, Ivin Varghese and the entire communications team for putting this together! @bcmfromthelabs.bsky.social
Ogilvie Lab | Texas Children's
texaschildrens.org
link.springer.com/article/10.1...
Tom Hartley@tomhartley.me.uk · 9mo agoMy suspicion from dealing with Reviewer 2 over a 30-year career was that PIs can contribute by supporting balance in e.g., journal clubs. I think new generations of GLPs are raised at PhD/postdoc level, when trainees are encouraged to be destructively critical of other labs' work.
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
☕@drmingyaoli.bsky.social & co present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments. bit.ly/4j2rIcG
Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues - Nature Cell Biology
Yuan et al. present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.
bit.ly
Happy Thanksgiving! To cap off 2025, we are pleased to share our Perspective piece in @cp-devcell.bsky.social on medulloblastoma stem cell programs. www.cell.com/developmenta...
Medulloblastoma stem cell programs: Molecular roadmaps of disease progression
In this perspective, Zagozewski et al. summarize current knowledge about the primitive neurodevelopmental programs that drive medulloblastoma progression. The authors also highlight the unmet needs in...
cell.com
EZHIP has been puzzling us for years because of its incompletely understood role in pediatric brain tumors. Here we report new functions for EZHIP and that EZHIP is not only mutated in PFA ependymoma, but also in K27M+ HGGs with EGFR mutations. actaneurocomms.biomedcentral.com/articles/10....
EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism - Acta Neuropathologica Communications
It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZ...
actaneurocomms.biomedcentral.com
Happy to welcome Dr. Xinmiao Yan, our new bioinformatician, to the Ogilvie lab! Thrilled to have her join our expanding team of medulloblastoma researchers!
🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨 www.nature.com/naturecareer...
Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry - Montréal, Quebec (CA) job with Université de Montréal | 12843808
Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry involved in the production of complex behaviors
nature.com
Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children. These children need MORE funding and MORE trials, not less. They deserve better
SickKids Research Institute has just launched a search for Program Head in Developmental, Stem Cell and Cancer Biology. Phenomenal colleagues, amazing science and great food all in the most multicultural city in the world. Join us: www.sickkids.ca/en/research/...
Developmental, Stem Cell & Cancer Biology | SickKids Research Institute
The Developmental, Stem Cell & Cancer Biology program has led significant discoveries in developmental genetics, genomics, stem cell and cancer biology.
sickkids.ca
Thank you to the Sam Day Foundation for funding our work on medulloblastoma metastasis! We are very grateful for the support! 🙏🏻🎗️
☕Attending the @isscr.org meeting next week and looking for a recap of interesting work in the field during the past year? Take a look at our collection of #StemCell and development papers published across @natureportfolio.nature.com during the past 12 months! www.nature.com/collections/...
A year of stem cell and developmental biology
In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...
nature.com
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
Happy to welcome 2 new lab members! Lily and Baoqi are PhD students in the Cancer & Cell Biology Graduate Program, and we are thrilled that they have joined our medulloblastoma research team! @bcmfromthelabs.bsky.social
We (the Nature Biology team) are looking for a locum edigtor to handle stem cell biology, developmental biology, and specific aspects of general cell biology, either in our Berlin or New York offices. springernature.wd3.myworkdayjobs.com/SpringerNatu...
Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences)
Job title: Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences) Location: New York or Berlin (Hybrid working pattern) Deadline: June 11th , 2025 About Springer Nature G...
springernature.wd3.myworkdayjobs.com
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
EANO@eanoassociation.bsky.social · last yr.💪Neuro-Oncology Pediatrics – a new open access journal by EANO & @neuroonc.bsky.social for the global #pediatric & AYA #NeuroOncology community. Now open for submissions! 🔗 academic.oup.com/neuro-onc-peds Editor-in-Chief: S. Mueller Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
👋Our May issue's out! Cover: #medulloblastoma #metastasis 👉🏼Comment on #autophagy in #aging 👉🏼Review on #lipid signaling & #CellMigration 👉🏼Review on #fibroblasts 🔬 #trophectoderm #NuclearEnvelope #lysosomes #PhaseSeparation #chromatin in #cancer & more! www.nature.com/ncb/volumes/...
I will be 49 in three months and just got asked whose lab I’m in. I still haven’t figured out a graceful way to reply! I usually have to repeat “my own” because ppl don’t seem to get what I mean. Does anyone have a clever reply that also emphasizes the assumption the person has made?
🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...
It’s been a hectic few days, here’s a quick thread on our latest endeavour exploring GABAergic neurogenesis in the human cerebellum published in @pnas.org. Key takeaways: Purkinje cells are born very early in human development — much earlier than previously appreciated. www.pnas.org/doi/10.1073/...
Mapping the developmental profile of ventricular zone–derived neurons in the human cerebellum | PNAS
The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs...
pnas.org
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether. https://go.nature.com/43ao2zq
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
go.nature.com
