Ed Phelps
@eaphelps.bsky.social
Associate Professor of Biomedical Engineering at the University of Florida. I study Beta Cell Biology, Biomaterials Engineering, and the Immunology of Type 1 Diabetes. https://www.bme.ufl.edu/labs/phelps/
New paper in @diabetologiajnl.bsky.social on paracrine control of insulin secretion, led by the talented newly minted Dr. Ryan Hart (@ryanhart13.bsky.social). 1/5 doi.org/10.1007/s001...
Awesome idea, bridging Excel with ggplot2 ⬇️ Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
biorxiv.org
A potentially targetable pathogenic signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk #islets @diabetologiajnl.bsky.social link.springer.com/article/10.1...
With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
Once upon a time I just admired nudis and sea slugs. But it was not enough. Now apparently I'm creating an R package to celebrate their colour palettes? 😅 First up, my Sydney fave, Hypselodoris bennetti. #rstats #nudibranch #dataviz 🦑🐙🧪 #marinelife #invertebrates
"i have two Microsoft Outlooks, and neither one of those are working." The Astronauts truly representing us all up there.
niki grayson@nikigrayson.com · 4mo agoright now the astronauts are calling houston because the computer on the spaceship is running two instances of microsoft outlook and they can't figure out why. nasa is about to remote into the computer
Pleased to share our latest research where we investigated a potential new drug for type 1 diabetes in slices of living human pancreas tissue from nPOD donors #industrycollaboration with Immunocore @bruskolab.bsky.social @ufbme.bsky.social @ufresearch.bsky.social www.science.org/doi/10.1126/...
Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices
A beta cell–targeting, affinity-enhanced TCR fused to a PD-1 agonist inhibits cellular immunity relevant to human type 1 diabetes.
science.org
PSA: Do not take your plasmids for granted. Sequence EVERYTHING. Trust no one.
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity - Nature Metabolism
Through an epigenome-wide blood analysis in children of mothers with or without type 1 diabetes, the authors identify epigenetic modifications of type 1 diabetes susceptibility loci through which mate...
nature.com
Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira www.sciencedirect.com/science/arti...
Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations
Gamma-aminobutyric acid (GABA) is produced in pancreatic beta cells and is implicated in modulating islet function, yet its precise physiological role…
sciencedirect.com
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...
biorxiv.org
Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD www.cell.com/cell-reports...
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...
cell.com
I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social www.cell.com/cell-reports...
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...
cell.com
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
nejm.org
What an amazing time to be a biomedical scientist. www.nejm.org/doi/abs/10.1...
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
nejm.org
Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress. link.springer.com/article/10.1... 🔓
Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donor...
Aims/hypothesis Progression to type 1 diabetes is associated with genetic factors, the presence of autoantibodies and a decline in beta cell insulin secretion in response to glucose. Very little is kn...
link.springer.com
When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday
How academics imagine their lives would look like if they decide to work in tech
I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...
Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...
biorxiv.org
Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.
Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social www.biorxiv.org/content/10.1... #CalciumImaging #Diabetes
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
nature.com
Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too! bme.ufl.edu/events/uf-bi...
