Preprint out! We optimized synchro-PASEF for phosphoproteomics & found equivalent biological insights to dia-PASEF despite fewer total IDs. Practical tip: apply retention time summation factor 2 to any PASEF phosphoproteomics data—you'll gain IDs and precision. www.biorxiv.org/content/10.6...

Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling

High-throughput data-independent acquisition (DIA) workflows paired with short chromatographic separations are increasingly adopted for systems biology and clinical proteomics. However, narrower peak ...

biorxiv.org

I'm excited to share the first work from my postdoc in the von Zastrow lab! We address a fundamental question about neuromodulatory signaling: Can neurons tell the difference between multiple neuromodulatory inputs when they converge on only a few receptor pathways? www.biorxiv.org/content/10.6...

Temporal coding expands the bandwidth of GPCR-mediated neuromodulation

The advent of modern transcriptomic approaches has revealed a breadth of neuromodulatory G protein-coupled receptor (GPCR) co-expression far exceeding what was previously thought. This raises a fundam...

biorxiv.org

Excited for the ASPET Annual Meeting next week! The Blythe Lab will be presenting three posters -- stop by to meet the team and see what we've been working on.

New publication! Here, we explore how endocytosis differentially sculpts signaling downstream of three endogenously co-expressed GPCRs: www.sciencedirect.com/science/arti...

GPCR-selective effects of endocytosis on cellular signaling through the cAMP / PKA cascade

Many GPCRs use endocytosis to promote gene transcription by prolonging signaling through the Gs-coupled cAMP / cAMP-dependent protein kinase (PKA) cas…

sciencedirect.com

Members of the UMN Twin Cities AAUP voted unanimously to endorse this Statement of Solidarity with Somali and Immigrant Communities drive.google.com/file/d/1WDWq...

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline. Apply here: hr.umn.edu/jobs/Find-Job Assistant Prof job code: 364920 Associate/Full Prof job code: 364921

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature

Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

nature.com

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

🚀 Hey #GPCR community on #bluesky! 🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬 📅 Nov 12–14, 2025 This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR! #GPCRforum #ScienceTogether

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science. www.sciencedirect.com/science/arti...

Emerging Voices in GPCR Biology

sciencedirect.com

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

"Talent and grit matter, but so do structure, transparency, and care." #ScienceWorkingLife https://scim.ag/4nCiPYg

Applying to the NSF-GRFP (or another fellowship) on a tight deadline? We built a 7-week guide + timeline to get you from draft to submission. It’s not too late — you’ve got this! ✨ 🔗 cientificolatino.com/apply-in-7-weeks #NSFGRFP #GradSchool #Fellowship

New NYT article detailing new requirements for the COVID-19 vaccine across US. This is all very preliminary information, but I suggest if you live in these states that may require a prescription, you acquire a script from your family doctor asap.

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv. 🔗 doi.org/10.1101/2025... We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer! A short🧵

The Blythe Lab is growing! This summer we welcomed our first lab members: junior researcher Eamon Cole and postdoc Dr. Chantel Mastos.

A new paper proposes an ‘intracrine’ signaling mechanism whereby a G protein-coupled receptor (FFA4) senses locally released fatty acids on intracellular membranes associated with lipid droplets to efficiently regulate lipolysis in adipocytes www.nature.com/articles/s41...

Intracrine FFA4 signaling controls lipolysis at lipid droplets - Nature Chemical Biology

An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on intracellular membranes associated with lipid d...

nature.com

🚨 New preprint alert! 🚨 Excited to share my latest work, now on bioRxiv: “Altered striatal dopamine regulation in ADGRL3 knockout mice” 🔗 www.biorxiv.org/content/10.1...

Altered striatal dopamine regulation in ADGRL3 knockout mice

Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupl...

biorxiv.org

“If you cut out these diversity measures, you're going to make science full of people that are very elite…Full of people who have grown up with a large amount of privilege, who were able to work in a lab in high school because their dad was a prof at Cornell.” 🧪 www.nytimes.com/2025/07/10/u...

How Trump’s D.E.I. Cuts Are Hurting Rural White Americans Too

nytimes.com

BOOM! Last nite we blew through the 20K mark and already @ 21K and counting. Wanna feel what it feels like to stand together w/ 20,000+ other science stans supporting the heroes of the #BethesdaDeclaration? CLICK to sign our #NIHLoveLetter here actionnetwork.org/forms/add-na... #StandUpForScience

If you weren't angry enough already, here are the rates of non-competitive renewals through May. 4008 Non-competitive renewals were due to be funded in May. The total funded was 99! Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments. 1/2

The Trump administration is unlawfully seeking to destroy higher education in the United States. It now demands that we sacrifice our international students in the process. Universities cannot acquiesce to such extortion.

Academe@academemagazine.bsky.social · last yr.

New on Academe Blog: academeblog.org/2025/05/23/a...

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species. Learn more in a new #SciencePerspective: scim.ag/43iprSX

Astrocytes, hidden puppet masters of the brain

Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

scim.ag

The NIH has dropped its research funding by $2.7 billion so far this year. Cancer research funding has declined 31%. And new NIH research grants fell to the lowest level in more than a decade. Eye-opening findings in today's HELP committee minority report: www.sanders.senate.gov/wp-content/u...

New report from Bernie Sanders, ranking member on the HELP committee www.sanders.senate.gov/wp-content/u... Lots of substance in here. Some highlights... 1/n

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration. www.ascb.org/society-news...

Science article with perspectives from NIH insiders www.science.org/content/arti... 1/n

NIH insiders: Trump is ‘dismantling and destroying everything’

After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding

science.org

Excited to share my first paper from my postdoc! In this study, we demonstrate that the mu opioid receptor produces a second wave of G protein activity on endosomes in a manner that doesn’t require receptor internalization. Check it out! www.pnas.org/doi/10.1073/...

Happy to have this out there! I had a lot of fun working with (and learning from) @akshitg.bsky.social on this mini-review on microdiversity in microbial populations and how current ecological theory fails to quantitatively explain the observations. doi.org/10.1111/1462...

Paradox of the Sub‐Plankton: Plausible Mechanisms and Open Problems Underlying Strain‐Level Diversity in Microbial Communities

“Paradox of the sub-plankton: Plausible mechanisms and open problems underlying strain-level diversity in microbial communities” by Akshit Goyal* and Griffin Chure*. This work highlights the limitati...

doi.org

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival. www.ourhealthroi.com

Our Health ROI

Explore how your tax dollars fund life‑saving medical research.

ourhealthroi.com