☀️Our July issue's out! Cover: #lysosome #metabolite 👉Editorial: #StemCell #embryo models 👉Perspective: #proteomics in #oocytes & embryo 👉Review: #ferroptosis in glial #tumors 🔬 #mitochondria #cytoskeleton #chromatin #BreastCancer #PhaseSeparation #lipids & more! www.nature.com/ncb/volumes/...
Amazing work from @albrechtlab.bsky.social ! To paraphrase recent title from one of the CNS journals: Subcellular Localization as a Driver of Cellular Metabolic State. Congratulations to the team! @ucirvine.bsky.social @ucirvinemedschool.bsky.social
Lauren Albrecht@albrechtlab.bsky.social · 5mo agoExcited to share our latest work out today in @naturemetabolism.bsky.social @ucirvine.bsky.social www.nature.com/articles/s42...
RESEARCH | M Campos, @albrechtlab.bsky.social et al. (UC Irvine) Subcellular compartmentalization of glycolytic enzyme PFKM regulates cell fate during skeletal muscle differentiation 🧪
PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
dlvr.it
Join us this Thursday for two exciting talks on how the dynamic compartmentalisation of metabolism and metabolites can drive cell function and fate. @albrechtlab.bsky.social @dacolon.bsky.social
Metabolism in Development and Physiology, Virtual Seminar Series@devmetphys.bsky.social · 2mo agoJoin us for another exciting session by two amazing speakers on our favourite subject Metabolism next Thursday June 4 from 16:00 PM!
Fascinating study showing how lysosomes impact cellular metabolism of lipids. It was our pleasure to collaborate with @albrechtlab.bsky.social . More to come soon! #lysosomes #lipids
Lauren Albrecht@albrechtlab.bsky.social · 2mo agoExcited to highlight our newest work “Lysosome-derived methylarginine is a signaling metabolite of the lipidome” in Nature Cell Biology www.nature.com/articles/s41...
Fantastic collaboration with @albrechtlab.bsky.social ! Lysosomes as hubs to regulate cellular lipidome. #lysosomes #lipids
Excited to highlight our newest work “Lysosome-derived methylarginine is a signaling metabolite of the lipidome” in Nature Cell Biology www.nature.com/articles/s41...
Excited to share our latest work out today in @naturemetabolism.bsky.social @ucirvine.bsky.social www.nature.com/articles/s42...
PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
nature.com
Fantastic work!
Dr Dorota SK@drdorotask.bsky.social · 7mo agoFinally out! We studied the retinas of the longest-living vertebrate, the Greenland shark, and found that the retinas remain remarkably healthy in animals around 150 years old. What is the mechanism? It may be a highly efficient DNA repair system. Enjoy! www.nature.com/articles/s41...
Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...
Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tiss...
doi.org
🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis. bit.ly/3RaRwWY
The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology
Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.
bit.ly
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
science.org
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.
science.org
Lipidome, proteome, LSD. What’s not to love??
Aligning Science Across Parkinson's@asapresearch.parkinsonsroadmap.org · last yr.In a new publication from CRN Team Harper found that select LSDs can cause problems with mitochondria. Specifically, these LSDs can interfere with the recycling of iron, which is important for mitochondria to function properly 🔬 🔗 Check out the full #publication: shorturl.at/HTPqW
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Identification of the mammalian VPS4A as a selective lipophagy receptor
tandfonline.com
So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd
Honored to be a 2025 Sloan Research Fellow! #sloanfellow
Alfred P. Sloan Foundation@sloanfoundation.bsky.social · last yr.🎉Congrats to the 126 early-career scientists who have been awarded a Sloan Research Fellowship this year! These exceptional scholars are drawn from 51 institutions across the US and Canada, and represent the next generation of groundbreaking researchers. sloan.org/fellowships/...
Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF www.nature.com/articles/s41...
The role of ionic blockades in controlling the efficiency of energy recovery in forward bias bipolar membranes - Nature Energy
Bipolar membranes are increasingly being applied in a variety of electrochemical devices, yet understanding of how they operate in complex electrolyte environments is still limited. Here the authors o...
nature.com
Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC �� @danafarber.bsky.social
CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint! www.biorxiv.org/content/bior...
biorxiv.org
Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...
Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction
Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chained fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production. Many of ...
biorxiv.org
"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]" www.sciencedirect.com/science/arti...
... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins - Nature Chemical Biology
Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins in lysosomes.
doi.org
Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover. www.nature.com/nchembio/vol...
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...
