Our Centre for Epigenetics Conference is only a month away! If you haven't booked your tickets yet, you can do so by following this link: eshop.qmul.ac.uk/conferences-...

"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers! doi.org/10.1371/jour...

The selfish ribosome

In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensured the propagatio...

journals.plos.org

Mart Krupovic@mkrupovic.bsky.social · 7mo ago

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

Variation in the genes coding for RNA strands in ribosomes are associated with human traits, new research suggests. Learn more: https://scim.ag/4vrvSR4

Great feature piece by @cofford.bsky.social in @science.org about our findings about rDNA sequence variation in the @ukbiobank.ac.uk and its association with body size traits. Don't miss it!!! www.science.org/content/arti...

My lab and @smarino0111.bsky.social lab are currently looking for 2 PDRAs on a 3-year @bartscharity.bsky.social funded project. The posts will be based in Blizard Institute within Queen Mary Faculty of Medicine and Dentistry. Check out the details and apply here: qmul-jobs.tal.net/vx/mobile-0/...

More acrocentric investigations, this one led by @arhie.bsky.social 🕵🏻‍♀️ “Biobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomes” 🧵[1/8] 📄 www.biorxiv.org/content/10.6...

🚨 New Paper Alert!!! We continue exploring rDNA variation in the @ukbiobank.ac.uk and discover that the proportion of rDNA units harbouring specific sequence variants associates with human traits, particularly body size ones! Check it out 👇👇👇

Rakyan Lab@rakyanlab.bsky.social · 6mo ago

Super happy to share the published version of our study: “Germline sequence variation within the ribosomal DNA is associated with human complex traits” in Cell Genomics www.cell.com/cell-genomic...!

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...

jobs.icr.ac.uk

A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk

A new test to predict which people with inflammatory bowel disease will get bowel cancer

Dr Baker and Professor Graham are developing a non-invasive way to predict bowel cancer risk in people who have inflammatory bowel disease.

bowelcanceruk.org.uk

If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!

bioRxiv Genomics@biorxiv-genomic.bsky.social · 9mo ago

Origin and evolution of acrocentric chromosomes in human and great apes https://www.biorxiv.org/content/10.64898/2025.12.22.696095v1

Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...

Postdoctoral Research Associate in Computational Muscle Biology at King's College London

Apply for the Postdoctoral Research Associate in Computational Muscle Biology role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

jobs.ac.uk

Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...

Postdoctoral Research Associate in Computational Muscle Biology at King's College London

Discover Postdoctoral Research Associate in Computational Muscle Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

jobs.ac.uk

Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Specificity, length and luck drive gene rankings in association studies - Nature

Genetic association tests prioritize candidate genes based on different criteria.

nature.com

@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS. Get in touch for any questions and apply by 2 December: my.corehr.com/pls/kclrecru...

New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬 A big step for precision medicine! www.nature.com/articles/s41...

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database - Nature Communications

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD),…

nature.com

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

Together with Chris Bell and Alexander Dawson, we are recruiting an PhD student (LIDo iCASE) at @qmulepigenetics.bsky.social to work on using long read nanopore technology to investigate DNA methylation on native DNA. This is a joint project with ONT. www.findaphd.com/phds/project...

🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...

The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]

kcl-mrcdtp.com

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

kcl.ac.uk

📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

biorxiv.org

NIH is allowing us to recruit postbacs and postdocs again. Please reach out if you are interested in working with us! Ad: genomeinformatics.github.io/jobs2025/

Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...

🧵1/ 🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...

An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. Here, we examined the structured and disordered RNA-bin...

biorxiv.org

I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social qmul-jobs.tal.net/vx/mobile-0/.... Pls share.

Just wanted to remind folks of the upcoming abstract submission deadline for the 2025 Human Genetics and Genomics GRS on March 30! 🧬 Come join us in beautiful Portland, Maine from July 5-6! Check out this link for more details: www.grc.org/human-geneti...

We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below: www.eventbrite.co.uk/e/qmul-centr... @qmul.ac.uk @bartscharity.bsky.social @qmulepigenetics.bsky.social

QMUL Centre for Epigenetics Launch Conference 2025

Join us in celebrating becoming an official Centre for Epigenetics at QMUL!

eventbrite.co.uk

Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...

Open letter to the President of the Royal Society – time to stand up for your values

If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...

docs.google.com

Had the pleasure of hearing about this cool story from @rakyanlab.bsky.social and @franrodalg.bsky.social last summer, congrats to all involved.

Rakyan Lab@rakyanlab.bsky.social · 2y ago

Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data! www.biorxiv.org/content/10.1...