I’m delighted to share that I’ve been selected as one of the 2026 @dev-journal.bsky.social Pathway to Independence Fellows. I’m excited to learn from editors and mentors, and engage with an outstanding cohort of fellows as I move toward the next stage of my academic career.

Development@dev-journal.bsky.social · 3mo ago

We are pleased to welcome 8 new fellows to our Pathway to Independence programme. Welcome Maëlle Bellec, @iamzico.bsky.social, @evhealy.bsky.social, @josepmercadal.bsky.social, @nikhil-mishra.bsky.social, Jessica Perochon, Yamini Ravichandran & Margherita Zamboni. Read more⤵️ tinyurl.com/4bk4wrk7

Welcome 2026 @dev-journal.bsky.social Pathway to Independence (PI) fellows Maëlle Bellec, @iamzico.bsky.social, @evhealy.bsky.social, @josepmercadal.bsky.social, @nikhil-mishra.bsky.social, Jessica Perochon, Yamini Ravichandran & Margherita Zamboni More info journals.biologists.com/dev/pages/pi...

Submit a science spotlight proposal to contribute to the scientific programming at #ISSCR2026! Organized by @ISSCR.org student & postdoc members, these sessions provide a fresh perspective on emerging scientific topics. Proposals are due 25 February invt.io/1bxblv0w3zj

Submit a Science Spotlight Proposal by 25 February.

Learn more.

invt.io

There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbhh15upf @ISSCR.org

Join me at the ISSCR 2026 Annual Meeting!

Register now

invt.io

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

nature.com

Thrilled to be selected as an #ISSCR2026 Ambassador! The @isscr.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxb53avp9c

I'm an ISSCR 2026 Ambassador, join me!

Register now

invt.io

Catch up on Development presents… webinar on gut development Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi... thenode.biologists.com/catch-up-on-...

Catch up on Development presents… webinar on gut development - the Node

Our September webinar featured three early-career researchers working on gut development. Here, we share the talks from Surojit Sural (Columbia University) and Swarnabh Bhattacharya (Dana-Farber Cance...

thenode.biologists.com

Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social. 📆 17 September, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...

Thanks to @rkzwick.bsky.social for writing this excellent preview and thoughtful discussion on our recent article @cp-cellstemcell.bsky.social (t.co/TkDxt1b3DH)

Cell Stem Cell@cp-cellstemcell.bsky.social · last yr.

Online Now! To play Paneth or goblet: Shapeshifting secretory cells read the room #stemcells

Honored to receive a Pilot & Feasibility grant (P30 DK034854) from the Harvard Digestive Disease Center to explore cellular plasticity and the epigenetic drivers of inflammatory bowel disease. Excited to uncover new insights into IBD pathogenesis!

I’m thrilled to have our work—“Intestinal secretory differentiation reflects niche-driven phenotypic plasticity of a common signal-responsive terminal cell” (dlvr.it/TK2Fzl) featured in the Preview of this issue of @cp-cellstemcell.bsky.social!

To play Paneth or goblet: Shapeshifting secretory cells read the room

The intestinal secretory lineage is thought to comprise four distinct cell types derived from one Atoh1+ progenitor, but the mechanisms that distinguish Paneth and goblet cells are unclear. Bhattachar...

cell.com

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

nature.com

Check out this exciting preprint from @aznarbenitahlab.bsky.social discovering a new mode of crosstalk between YAP and the circadian regulator BMAL1. Congrats @juliabonjoch.bsky.social and @guiomarsolanas.bsky.social for fantastic work and thank you for the fun collaboration!

Júlia Bonjoch@juliabonjoch.bsky.social · last yr.

Hi Bluesky community:) Our new manuscript is now available as a preprint!⛅️ biorxiv.org/content/10.1... 1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵

Online Now! Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell #stemcells

Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell

Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive ATOH1+ cell type and that goblet and Paneth cis-elements and the canonical genes they control interconvert upon modulation of Wnt and BMP signals.

dlvr.it

I am excited to share my latest Postdoctoral work @cp-cellstemcell.bsky.social @cellpress.bsky.social (dlvr.it/TK2Fzl), in which we reveal that goblet and Paneth cells aren’t fixed lineages but represent dynamic states influenced by local cues. Here's a walkthrough of what we found (🧵)....

Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell

Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive A...

dlvr.it

Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signaling in murine ileitis @naturecomms.bsky.social www.nature.com/articles/s41...

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis www.science.org/doi/10.1126/... @nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social

Vagal pathway activation links chronic stress to decline in intestinal stem cell function @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

🔦Spotlight of Peter Dempsey, @brumbaugh-lab.bsky.social et al paper: Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells by @iamzico.bsky.social and Ramesh Shivdasani at @danafarber.bsky.social http://dlvr.it/TJfVRZ

It was fun to write this Spotlight article @cp-cellchembiol.bsky.social on the recent NCB paper (rdcu.be/eayN3) by @brumbaugh-lab.bsky.social & Dempsey labs, revealing how epigenetic fluidity drives phenotypic malleability in the intestinal epithelium. www.sciencedirect.com/science/arti...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Measuring and manipulating mechanical forces during development - Nature Cell Biology

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

nature.com

📣Funded #PhDposition! – Pls RT! Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging. Join us @VetmeduniVienna in a vibrant research environment! #CancerResearch #PhD 👉 euraxess.ec.europa.eu/jobs/302158

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

biorxiv.org

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

rdcu.be

New research in @nature.com led by Ramesh A. Shivdasani, MD, PhD, of @danafarber.bsky.social gives insight into how intestinal tumors develop. https://go.nature.com/42cMksp

Crypt density and recruited enhancers underlie intestinal tumor initiation @Nature www.nature.com/articles/s41...

New Publication Alert from Shivdasani Lab!! 🚨🚨 Adenomas don’t form just because of Apc mutations—they require cooperation between mutant intestinal crypts. Congratulations to Liam and all the authors! Thrilled to be part of this fantastic study! @nature.com rdcu.be/d5DQh

Cool study from @katemiro.bsky.social and @dfachinetti.bsky.social labs showing how chromosome abnormalities activate p53 through nuclear envelope stress 🤩 Congrats to all!

Kate Miroshnikova@katemiro.bsky.social · 2y ago

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

Do you want to study #cancer #microbe interactions using #organoids and #organ #chips? Have a look at our guide to co-culture platforms, just out in Int J Cancer with Jens Puschhof, Hans Clevers, Eran Elinav and fellow @emil-dkfz.bsky.social colleagues: onlinelibrary.wiley.com/doi/10.1002/...

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggest...

onlinelibrary.wiley.com

Excited to share my new @cellcellpress.bsky.social paper from @thecleverslab.bsky.social was published today! Thanks to @hansclevers.bsky.social and all our collaborators. #organoids #stemcells #pancreas

@thecleverslab.bsky.social · 2y ago

📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @cellpress.bsky.social by @amandaanderssonr.bsky.social , @hansclevers.bsky.social and collaborators. See the article here: www.sciencedirect.com/science/arti...