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Jayne Sutherland

@jaynesutherlandtb.bsky.social

Professor of Immunology at LSHTM. Head of TB Research Group at MRC Unit The Gambia. Research focus on lung and blood biomarkers across the infection spectrum, diagnostics, co-infections and post TB lung disease.

77 Posts732 Follower106 Folgt
Claas Kirchhelle@kirchhelle.bsky.social · last mo.

A bit late sharing this - but very happy to featured on the new BBC News CrowdScience episode on the history of #tuberculosis & the first trial of the Bacillus Calmette-Guérin (BCG) #vaccine in Paris in 1921. www.bbc.co.uk/programmes/w... ➡️ the BBC World Service version airs on Monday

BBC World Service - CrowdScience, Why is TB still killing people?

Tuberculosis kills over a million people every year, despite a vaccine and a cure. Why?

bbc.co.uk

Max Gutierrez@maxgg.bsky.social · 4mo ago

Very excited this work by Victor and Jakson @crick.ac.uk is out!! started many years ago with @jvaubourgeix.bsky.social They generated Mtb-Timer, a fluorescent reporter in Mtb as a proxy for Mtb replication and measure antibiotic responses Mtbhttps://journals.asm.org/doi/10.1128/msystems.01796-25

Mtb-Timer: a fluorescent reporter to visualize Mycobacterium tuberculosis replication and antibiotic responses | mSystems

Tuberculosis treatment is challenging in part because Mycobacterium tuberculosis (Mtb) populations are phenotypically heterogeneous. Within the same infection, bacterial cells can exist in different physiological states, from actively replicating to slow-growing or non-replicating forms. To better study these processes, we developed and validated Mtb-Timer, a fluorescent reporter that enables visualization of bacterial growth dynamics. The system is based on a fluorescent protein that changes color over time: newly synthesized protein emits green fluorescence (GFP) and gradually shifts to red (DsRed) as it matures. The green-to-red fluorescence ratio, therefore, reflects bacterial replication activity. Using microscopy and flow cytometry in both in vitro cultures and infected macrophages (in cellulo), Mtb-Timer enables the quantification of distinct bacterial subpopulations and the real-time monitoring of the green-to-red fluorescence ratio and bacterial burden during treatment with first-line antibiotics.

journals.asm.org

Nature Reviews Immunology@natrevimmunol.nature.com · 7mo ago

Fibroblasts as regulators of lung immunity, repair and fibrosis

Fibroblasts as regulators of lung immunity, repair and fibrosis

Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01268-4Fibrosis disrupts organ function through excessive extracellular matrix deposition, particularly in pulmonary cases. Insights from single-cell sequencing reveal fibroblast heterogeneity and regulation by immunological, mechanical and metabolic factors, highlighting pathways leading to progressive fibrosis versus effective tissue repair.

dlvr.it

Colette Delawalla, PhD@cdelawalla.bsky.social · 8mo ago

Here’s the deal with the FY26 NIH funding bill: One line in the 1000+ pg bill = significantly less science. The increase to ~40% of grants moving to MYF is estimated to result in a 35% decrease in the NUMBER of NIH grants funded annually—moving the paylines from 10% to around 4%. THIS IS BAD.

Jayne Sutherland@jaynesutherlandtb.bsky.social · 9mo ago

This is good news and about time too. Crazy to still be having chicken pox parties when there is a perfectly good vaccine available that will not only protect kids from chicken pox, but also reduce the horrible effects of shingles in later life. www.theguardian.com/society/2026...

UK children to get chickenpox vaccine with measles, mumps and rubella jab

NHS to administer combined immunisation in move in line with approach in US, Canada, Australia and Germany

theguardian.com

Michael Marks@drmichaelmarks.bsky.social · 9mo ago

Still time to apply and come and do modelling PhD on STI transmission and partner notification with me! UK fees & stipend covered. Get in touch to discuss before the application deadline of 14th January. @tah-sci.com @rozeggo.bsky.social @adamjkucharski.bsky.social @drlouisedyson.bsky.social

London School of Hygiene & Tropical Medicine@lshtm.bsky.social · 9mo ago

👋Our MRC-LID studentships are now open for applications with @citystgeorges.bsky.social MRC-LID provides research opportunities focused on improving #GlobalHealth with skills, training & the expertise of 2 specialist institutions. Apply by 14 Jan 2026👉 mrc-lid.lshtm.ac.uk

BK. Titanji@boghuma.bsky.social · 9mo ago

Five real global health wins in 2025 1.HPV vaccination scaled faster than expected; 2. measles/rubella eliminated in several countries; 3. long-acting HIV PrEP (lenacapavir) approved; 4. progress on TB vaccines/diagnostics; 5. A promising new antimalarial. www.theguardian.com/global-devel...

Five big global health wins in 2025 that will save millions of lives

From HIV to TB, scientists and doctors made breakthroughs in treatment and prevention of some of the world’s deadliest diseases

theguardian.com

Joanne Flynn@joanneflynn19.bsky.social · 10mo ago

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!

Tedros Adhanom Ghebreyesus@drtedros.who.int · 11mo ago

Sudden and unplanned cuts to aid have hit many countries hard, costing lives and jeopardizing hard-won health gains. Today, @who.int issued a guidance to help countries to better mobilize, allocate, prioritize and use funds to support the delivery of health services: bit.ly/47z3hOv #HealthForAll

WHO issues guidance to address drastic global health financing cuts

The World Health Organization (WHO) today released new guidance for countries on ways to counter the immediate and long-term effects of sudden and severe cuts to external funding, which are disrupting...

bit.ly