José Delgado, Ph.D.
@jmdelgado.bsky.social
Studying mitochondrial responses to infection at UCLA | Mitochondriac | Autophagy| DEI | Outdoor enthusiast | he/él | 🇲🇽⛰🚴🏼🏳️🌈 https://josedelgadophd.wixsite.com/jose
California Bill Would Create A $23 Billion Fund For University Research
California Bill Would Create A $23 Billion Fund For University Research
A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.
forbes.com
🚨New Pernas Lab Preprint is live!! 🚨 Here we show that mitochondria shed "new organelles" that engulf lysosomes and become acidified compartments during intracellular infection! Video below shows SPOTs acquiring a lyso (C: matrix, Y: OMM, R: Lyso) 🔬. 🔗: www.biorxiv.org/content/10.6...
🚨UCLA and broader California science community Join me in supporting SB 895: California Science & Health Research Bond Act Sign ✍🏽: www.fundcascience.org Email legislators!
Fund CA Science
fundcascience.org
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Gift link. NYT article about the fallout in one Harvard lab from the vandalism to the NIH. www.nytimes.com/2026/03/13/u...
His Harvard Lab Was Thriving. Then Came the Cuts.
nytimes.com
#NewResearch The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites. #MicroSky 🦠 www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
nature.com
🚨 New work out from the Pernas Lab. Congratulations to my labmate Chahat Mehra!! Host organelle - pathogen membrane contact sites!! ER edition! rdcu.be/eRKUM
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection
Nature Microbiology - The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
rdcu.be
Applications are open for the Postdoctoral Enrichment Program (PDEP)—supporting postdocs as they advance cutting-edge research and build thriving scientific careers. Learn more & apply: bwfund.org/pdep #bwfpdep
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research go.nature.com/4hriohE
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
go.nature.com
Last year, we helped 100 students save $31K in grad school app fees, giving students from underserved communities the freedom to apply widely. This year we lost 16 partners = $8.2K setback = 110 fewer dreams. 🎓 You can change that. 💸 Donate to open 110 new doors. givebutter.com/supportCL
NEXT WEEK: Applying to grad programs in the sciences? 🧬✨ Hear directly from university administrators about the key do’s and don’ts for a standout application. Join our Faculty Panel for practical advice & answers to your questions. 📅 10/7, 11am ET 📍 Register: www.eventbrite.com/e/faculty-pa...
Ribonucleotide incorporation into mitochondrial DNA drives inflammation www.nature.com/articles/s41... Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
nature.com
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti... #Reproducibility
Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience. I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
Katie Wilkinson@drkwilkinson.bsky.social · 12mo agoCalling all @apsphysiology.bsky.social members: let’s help raise some money to support ABRCMS student presentation awards! Goal is $1200/discipline to support 12 awards by Sept 30th! 🧪 abrcms.org/donate/stude...
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
nature.com
📣 Are you a undergraduate student, graduate student, or early-career professional in the biomedical sciences looking to transition from academia into industry? Join us for: Thriving in Biotech – Building Bridges, Breaking Barriers. www.scientistsinsolidarity.org/conference
Conference — Scientists in Solidarity
scientistsinsolidarity.org
🎓 Planning to apply to STEM graduate programs? Join us for our webinar: “Applying to Grad Programs in STEM” on Thursday, 8/28 at 5.30pm ET. Gain key insights on: ✅ Grad school application timeline ✅ How to choose the right program 🔗 Register: eventbrite.com/e/gsmi-2025-...
New work out of the Pernas Lab!! Congratulations to my lab mates, especially Tania for spearheading this great story!! 🎉 Mitochondria protect against an intracellular pathogen by restricting access to folate | Science www.science.org/doi/10.1126/...
Mitochondria protect against an intracellular pathogen by restricting access to folate
As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...
science.org
Great perspective piece out of my PhD lab! 👇🏽
Journal of Cell Biology@jcb.org · last yr.The rapidly expanding role of LC3-interacting regions in #autophagy. New Perspective from Brian North, @doroteaartscience.bsky.social, Christopher Shoemaker and colleagues (Geisel School of Medicine, Dartmouth College): rupress.org/jcb/article/...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
A story from LAist (local LA public radio) about the freezing of funds. I have had my grant frozen, so has nearly everyone else i know. laist.com/news/climate...
UCLA tells researchers to 'immediately stop spending' after Trump administration freezes grant funds
The Trump administration cited alleged antisemitism at UCLA as a reason for suspending the funding. Years worth of research could be lost, one UCLA researcher said.
laist.com
If you're a UCLA researcher (PI, grad student, etc) with an NSF, NIH or other suddenly suspended grant, please email or DM me. I'm trying to confirm what the suspension letters say and how extensive the NIH suspensions are. Email: Mikhail at calmatters dot org
Mikhail Zinshteyn@mzinshteyn.bsky.social · last yr.I chased this all day: UCLA research grants suspended after Trump administration faulted campus for antisemitism calmatters.org/education/hi...
Multiple federal agencies are suspending research funding at UCLA over allegations it didn’t properly deal with antisemitism on campus. scim.ag/4lbLAcx
NSF and NIH suspend grants to UCLA
Move follows Trump administration finding that school didn’t effectively combat antisemitism
scim.ag
The NSF grants suspended at UCLA total $179M, half of which was still outstanding: CAREER grants, a major math institute, and basic science research and training of all types. More at grant-witness.us/posts/UCLA-n..., thanks to GW member Mally Shan, with grant-level details in our database.
NSF Grant Suspensions at UCLA total $90M lost in value – Grant Witness
grant-witness.us
Dan Garisto@dangaristo.bsky.social · last yr.Breaking: NSF is suspending roughly 300 grants with UCLA, following a DOJ finding on Tuesday that the university violated Title VI by "creating a hostile educational environment for Jewish and Israeli students."
As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in human...
cell.com
