Excited for accepted #ACNP2027 panel co-chaired with @jojolab.bsky.social. @vikaassohal.bsky.social @suthanalab.bsky.social @rphillips3.bsky.social and Josh will present cross-species strategies that align rodent circuit interrogation w/ behavioral, physiological & molecular readouts in human 🧠

My dude! So stoked to see this project continue

Jorge Miranda Barrientos@jorge-miranda.bsky.social · 7d ago

I am so thrilled to share that i was selected to received the 2026 BBRF young investigator grant from the @bbrfoundation.bsky.social. This is meaningful for me. Thanks so much to @martinowk.bsky.social and the @lieberinstitute.bsky.social for all the support.

Our new preprint from @daylab.bsky.social characterizes Chst9-MSNs, a specialized NAc population with high Oprm1 expression and opioid sensitivity that is required for fentanyl reward learning. Excited to share this work! 🧠🧬 www.biorxiv.org/content/10.6...

For #FluorescentFriday, some more D1-island RNAscope from @ishbeldelrosario.bsky.social. These cells are so weird in all the best ways. Excited to share this data with everyone soon 😎🏝️

Notice of Award Monday! Grateful to NIDA for supporting some very exciting work defining the cellular and circuit mechanisms that opioids target to produce rewarding effects.

Fresh off the🔬for #FluorescenceFriday from @ishbeldelrosario.bsky.social - pretty RNAscope as part of our continued exploration of spatially-organized populations of D1R-expressing island populations in nucleus accumbens of human 🧠. Excited to be bringing some key updates to the data resources soon!

(9/10) Thank you to @lieberinstitute.bsky.social, NIDA, and all our collaborators who made this work possible. 🧑‍🔬 #NAcLIBD @svitlanabach.bsky.social, @rphillips3.bsky.social, @alexisbattle.bsky.social , @martinowk.bsky.social , @stephaniehicks.bsky.social, and @kr-maynard.bsky.social

I am so proud of the whole team, and excited for next steps. We are already building on these discoveries by examining spatial organization of D1 islands across the full anatomical extent of the NAc and integrating molecular maps with functional mouse circuit and behavior studies. So excited!!

Excited to share our new study characterizing spatial gene expression in the human NAc led by @prashanthi-ravi.bsky.social @svitlanabach.bsky.social @rphillips3.bsky.social in collaboration with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social @lcolladotor.bsky.social.

Neuron@cp-neuron.bsky.social · last mo.

New paper out online today!! We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk. www.nature.com/articles/s41...

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus - Molecular Psychiatry

Molecular Psychiatry - BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus

nature.com

Thrilled to share that our latest paper investigating how mPFC-LC projectors contribute to sustained #attention is now out in @npp-journal.bsky.social This is so meaningful to me and the team, Its @rehg-j.bsky.social first first-author paper and my first corresponding one. rdcu.be/fqBJp

Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

rdcu.be

A new $10 million philanthropic investment will establish the Frances Gorrie Alzheimer’s Disease Center at UAB, supporting clinical care and research into this neurodegenerative condition affecting over 7 million Americans. Read more here. www.uab.edu/medicine/new...

Check out our new paper, led brilliantly by Dr. Megan Brickner, in early view form at @natcomms.nature.com. We characterize BLA dopamine signaling in emotional learning - lots of insights into broad dopamine heterogeneity beyond classic value learning signals! www.nature.com/articles/s41...

Ben Saunders@bensaunders.bsky.social · 5mo ago

Check out our latest research drop! We show BLA dopamine signaling encodes the emotional weight of sensory transitions, but not the associative strength or value of stimuli. These signals dynamically rescale when the learning context changes: "this matters most!" www.biorxiv.org/content/10.1...

My PhD work on how lateral septum cells and circuits process threat cues to guide defensive actions is now online at @nature.com rdcu.be/fjNgT w/ @gordfishell.bsky.social and others

Feature-specific threat coding in lateral septum guides defensive action - Nature

The populations of CRHR2-expressing neurons in the lateral septum of mice involved in threat-related behaviour in response to environmental challenges are defined.

nature.com

Grateful for some absolutely spectacular weather ☀️ for our annual cross-research teams spring party!!

Glucose-Dependent Insulinotropic Polypeptide Receptors Are Expressed in the Lateral Septum and Reduce Electrically-Evoked Dopamine Release as well as the Ability of Cocaine to Increase Extracellular Dopamine | ACS Chemical Neuroscience pubs.acs.org/doi/10.1021/...

Glucose-Dependent Insulinotropic Polypeptide Receptors Are Expressed in the Lateral Septum and Reduce Electrically-Evoked Dopamine Release as well as the Ability of Cocaine to Increase Extracellular Dopamine

Tirzepatide, a dual agonist of the glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), represents a new class of medication for obesity and type II diabetes treatment. Using laboratory mice, we show that GIPRs are present in the lateral septum (LS) in cells also expressing GLP-1R, particularly in the dorsolateral LS. Likewise, we show the coexpression of the dopamine (DA) D2 receptor (DRD2) in LS cells with GLP-1R in both the dorsolateral and intermediate portions of the LS. Using fast-scan cyclic voltammetry, we demonstrate that systemic GLP-1R or GIPR agonist treatment reduces both electrically evoked DA release in the LS and the ability of cocaine to increase extracellular DA levels. These data unveil a new central role for GIPR signaling and identify a potentially important cell type expressing both GLP-1R and GIPR upon which tirzepatide or other dual agonists may modulate DA homeostasis in the brain.

pubs.acs.org

Thrilled to share my main postdoctoral work out @nature.com ! This project tackles a fundamental question: how do pregnancy and postpartum experiences promote lifelong changes to the brain? www.nature.com/articles/s41...

Dopamine drives persistent remodelling of the maternal brain - Nature

Brain-wide transcriptomic profiling in mice reveals that reproductive experience remodels the maternal brain by altering dopamine dynamics in the dorsal hippocampal formation, causing dopamine-depende...

nature.com

DREADDs in humans--update: 3 clinical trials using hM4Di in humans registered in China. 2 for epilepsy and 1 for Parkinson's Disease. In our original paper we stated: "...We suggest that at least one of these designer receptors, hM4D, will prove useful for neuronal silencing in vitro and in vivo.."

For #FluorescenceFriday, celebrating some more good paper news with this really pretty image labeling prefrontal cortical neurons with projections to the locus coeruleus with chemogenetic receptors. Image credit to @rehg-j.bsky.social @jorge-miranda.bsky.social 🧠🧪🔬

This work is now available online in @elife.bsky.social - thanks to the reviewers for excellent comments! Check it out if you are interested in the intersection of pain, opioids, and the ventral tegmental area! elifesciences.org/reviewed-pre...

Jeremy Day@daylab.bsky.social · 11mo ago

Excited to share this new work from the lab, in collaboration with @jtuscher.bsky.social & Rob Sorge! Here, we used single cell transcriptional profiling to define molecular adaptations induced by chronic pain and opioid experience, which often occur in conjunction. www.biorxiv.org/content/10.1...

For #FluorescenceFriday and in celebration of a paper acceptance - super excited to get this one out to the community soon 🤩, cluster of "D1 islands" in the nucleus accumbens of the human 🧠 (🟢 MBP; 🔴 DRD1; 🟡 RXFP1; 🟣 OPRM1). Image credit to @svitlanabach.bsky.social @ishbeldelrosario.bsky.social 🔬👩‍🔬

Yesterday I had the privilege to give a virtual talk to undergrad and graduate students in Mexico about some of our work at @lieberinstitute.bsky.social. It was great to connect with the community, and giving it in spanish felt so special. #cienciaenespañol!

Me today watching @nataliagonzalezp.bsky.social leave lab for the last time. Natalia is an outstanding scientist and is going to do great things at @mpfneuro.bsky.social!

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

👑

Keri Martinowich@martinowk.bsky.social · 4mo ago

Huge congratulations to newest PhD from our group @shkwon-bcmbneuro.bsky.social after thesis defense, "Spatial gene expression landscape of the human cortex in health and disease". Really grateful for the hard work, dedication and commitment to many, many projects, and the team science spirit.

A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself. Learn more on #WorldHealthDay: https://scim.ag/4oDvjAa

First #FluorescenceFriday post! Some islands in the human NAc 🏝️🧠. Forever fascinated with this really cool population. Shoutout to @svitlanabach.bsky.social for the incredible Visium-HD targeting!

Restaurants, billboards, commercials… what brain circuits link context to appetite? 🧠🌎🍽️ Very happy to finally share a major update in our work exploring the hippocampus and lateral septum in calibrating food consumption! 🍩 Major thanks to our lab and collaborators! ⭐️⭐️ www.cell.com/neuron/fullt...

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Goode et al. show that prodynorphin (Pdyn)-expressing neurons of the dorsolateral septum (DLS) receive substantial dorsal hippocampal (DHPC) input and inhibit lateral hypothalamic (LHA) GABAergic neur...

cell.com

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

Excited to share our study in Neuron led by @travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications