Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...

That’s a beautiful story that shows again how powerful long reads are for studying transposable elements. Exciting times! For accessing the Perspective piece without a paywall: www.science.org/eprint/NIKHD...

Why the X chromosome is rich in L1 mobile elements

Preferential insertion into the late-replicating inactive X explains L1 accumulation in this chromosome

science.org

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

I had an (honestly) really fun time writing up an "In Preprints" piece on the two fantastic studies from @grandlab.bsky.social and @schubelerlab.bsky.social. Check it out here. I have also put the original threads from the authors below. journals.biologists.com/dev/article/...

In preprints – housekeeping the housekeeping genes

The term ‘housekeeping gene’ evokes a sense of banality. These are the boring genes that hum in the background, impervious to cell state or stress. For a developmental biologist captivated by the impa...

journals.biologists.com

Coupes drastiques du budget de la recherche + durcissement des règles d’attribution des financements ANR «Allez à l’ERC!» qu’ils disent, mais l’ERC saturée prend des mesures pour limiter les candidatures #deadend#recherchefrançaise Une petition semble vaine mais il faut commencer quelque part 👉

Levayer Lab@levayerr.bsky.social · last mo.

Un pétition du collège des sociétés savantes pour mettre en avant le rôle de la recherche dans la campagne politique à venir et rappeler le sous investissement chronique en France depuis 20 ans. N'hésitez pas à faire ciculer recherche-publique-2027.fr

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

We built an AI that will tell you what will get your grant rejected. It’s a tough critique, but it’s better to know when you can still do something about it 👇 @qedscience.bsky.social

You want to design a very specific single AA mutation for CRISPR editing or interpret your newly identified natural polymorphism? This is for you 👇 with a user-friendly web tool, thanks to the PhD work of @abakamarina.bsky.social www.nature.com/articles/s41... shorturl.at/pFAZ7 shorturl.at/ogXb6

Proteome-wide prediction of the functional impact of missense variants with ProteoCast

You just identified a new mutations in your favourite but don't know whether it's functional Marina Abakarova 's PhD project, with the help of Maria Ines Freiberger Arnaud Liehrmann, and under the sup...

linkedin.com

🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS

Reminder: PhD position in my lab is open for two more weeks. How do germ cells use their own private transcription factors? Come help us find out. Fully funded. Deadline May 1. Flyer attached — please boost! 🙏

Peter Andersen@germline.bsky.social · 4mo ago

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

👇👇👇 If are you excited about helping us recruit and train the next generation of scientists, don't hesitate to apply! The @viennabiocenter.bsky.social is a great place to work. 🙂

Kristina Stapornwongkul@kstapornwongkul.bsky.social · 4mo ago

The @vbcscitraining.bsky.social is looking a PhD Program Manager! Needless to say this is an incredible important position. So please apply if you want to help us find, recruit and train the next generation of scientists! RT appreciated!

Yolanda and I enjoyed writing this review on X-chromosome reprogramming in the mammalian germline. 👇 Hope you'll enjoy reading it too! @biochemsoc.bsky.social #epigenetic #germline #XCI @igmm-montpel.bsky.social @biolum-montpellier.bsky.social @umontpellier.bsky.social

Yolanda Moyano Rodríguez@yolandamr.bsky.social · 4mo ago

Happy to share our new review on X-chromosome reactivation in the germline, just published in @biochemsoc.bsky.social Transactions! We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming. Hope you enjoy the read 😊

🦠 Quand un virus devient cheval de Troie 🔬 Cette découverte éclaire la transmission et l’évolution des deltavirus. 👉 www.insb.cnrs.fr/fr/cnrsinfo/... 👏 @karimaj.bsky.social @viroscope.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social #IGMM #CNRS #Virologie #Recherche

CNRS Biologie@cnrsbiologie.bsky.social · 5mo ago

#ResultatScientifique🔎| Le stratagème des deltavirus : voyager à bord d’un autre virus 🤝 @karimaj.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @igmm-montpel.bsky.social 📕 buff.ly/Z6ZIvRD

Save the date : Seminar by Kristina Zumer on Tuesday 24th March at 11h @uni-goettingen.de

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers

The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

biorxiv.org

💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇

Agnese Loda@agneseloda.bsky.social · 8mo ago

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

This is today !

IGMM-Montpellier@igmm-montpel.bsky.social · 10mo ago

Save the date : Seminar Dr Elphège Nora from UCSF on Tuesday 18 November at 11am @elphegenoralab.bsky.social

We are thrilled to host Elphège Nora next week in Montpellier 🤩 ☀️🧬 @elphegenoralab.bsky.social @cnrsbiologie.bsky.social @biolum-montpellier.bsky.social @umontpellier.bsky.social #transcription

IGMM-Montpellier@igmm-montpel.bsky.social · 10mo ago

Save the date : Seminar Dr Elphège Nora from UCSF on Tuesday 18 November at 11am @elphegenoralab.bsky.social

🧬Le magazine de la Métropole de Montpellier consacre un article à Jamal Tazi, pour son rôle dans la découverte de l’Obefazimod (ABX464), molécule issue de la recherche académique et développée grâce à une collaboration public-privé exemplaire. encommun.montpellier.fr/sites/defaul...

New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡 Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!

Institut Jacques Monod@ijmonod.bsky.social · 9mo ago

#JobOffer 💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod ➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍. 👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus” www.the-scientist.com/boa-constric...

Boa Constrictor Brain Cells Slither into Focus

From reptiles and Tasmanian devils to humans, one researcher zooms in on unseen features of the brain and liver cells, like the cytoskeleton.

the-scientist.com

The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍

The Francis Crick Institute@crick.ac.uk · 10mo ago

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

An Interview with Azim Surani Ashley Moffett and @geraldinejowett.bsky.social spoke to Azim, recipient of both the 2025 Kyoto Prize and 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, about his non-traditional and inspirational route into academia: journals.biologists.com/dev/article/...

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

nature.com

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

DNA methylation at #retrotransposons protects the #germline by preventing NRF1-mediated #activation. -> www.embopress.org/doi/full/10....

Maxim Greenberg@maxvcg.bsky.social · 12mo ago

Really beautiful work led by Jessica Leismann in Joan Barau’s lab @imbmainz.bsky.social . If you like elegant mouse genetics, the transposon arms race, and a healthy dose of epigenetics, this one’s for you. www.embopress.org/doi/full/10.... @emboreports.org

#jobAlert We are hiring! If you like #imaging ,gene regulation and a dynamic group please apply. We are looking for a research assistant with a master degree and prior experience in academia.

IGMM-Montpellier@igmm-montpel.bsky.social · last yr.

🎯 Hiring: Biology Research Assistant (M/F) Join IGMM Montpellier to study gene expression dynamics during Drosophila development @laghalab.bsky.social 6-month contract, renewable up to 2 years. Start Sept 15, 2025 | Apply by Aug 11 🔗 emploi.cnrs.fr/Offres/CDD/U... #Hiring #Biology #Research #IGMM