Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...

Topographic structure and function of locus coeruleus noradrenaline neurons - Nature

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

nature.com

Jeremiah Cohen@jeremiahycohen.bsky.social · 6mo ago

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Nothing quite like finding a perfect home for work close to your heart. Out now in @plos.org CompBiol is our #open-source toolbox for circular permutation testing in #brain-body #neuroskyence. 🫂 @teresaberther.bsky.social & @eliobalestrieri.eurosky.social 🔗 journals.plos.org/ploscompbiol... 🧵🔽

Starting September 1, I will be working with a team to start a new research center at the Max Planck Institute for Human Development in Berlin. We currently have a couple of positions posted but there will be more so if you are interested stay tuned and feel free to get in touch.

Max Planck Institute for Human Development@mpib-berlin.bsky.social · 3mo ago

📣 New research center on the horizon! The Center will study how midlife autonomic changes may contribute to #neurodegenerative disease risk, focusing on the locus coeruleus, #Alzheimer’s biomarkers, and emotion–cognition interactions. Interested? CAAN-Job openings 👇 www.mpib-berlin.mpg.de/career

Super excited to see our review out in TiCS! Here me & @cogsci.nl present the first comprehensive framework of the mechanisms driving relationships between spontaneous pupil-size fluctuations, neural activity, and behavior 👀🧠👩🏻‍💻 Spoiler: arousal is only one of at least four 😶‍🌫️ doi.org/10.1016/j.ti...

📢 LIP colleague @sarahdpower.bsky.social is looking for a PhD student for her project "Mapping Early Memory Trajectories Across Species (ATLAS)". careers.mpib-berlin.mpg.de/jobs/8116017...

PhD Position (m/f/d) in Berlin, Germany - Max-Planck-Institut für Bildungsforschung

At the Max Planck Institute for Human Development, we study how and why people develop differently over the course of their lives, and how physical, societal, and technological aspects of the envir...

careers.mpib-berlin.mpg.de

Interested in how dysregulation of locus coeruleus-norepinephrine circuits contribute to neuropsychiatric symptoms in early Alzheimer's disease? Check out our new review article from freshly minted Dr. Anu Korukonda! www.nature.com/articles/s41...

A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms - Molecular Psychiatry

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

nature.com

🎉New paper out today in Nature Reviews Psychology🎉 with @mjdahl.bsky.social, @mariamaly.bsky.social, and @thiasmittner.bsky.social. We've been working on a unified framework for attentional states and the dynamics of transitions between them. 🧵

📢 New paper out in @nathumbehav.nature.com: we identify a previously undescribed fast thalamic oscillation (~19–45 Hz) in rare intracranial human recordings that appears specifically during wakefulness and REM sleep — but disappears during NREM sleep. www.nature.com/articles/s41...

New manuscript from undergrad Alexia and @davidweinshenker.bsky.social on the molecular and behavioral effects of early locus coeruleus lesions in the TgF344-AD rat model alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model

INTRODUCTION In murine models of Alzheimer's disease (AD), lesioning the locus coeruleus–norepinephrine (LC-NE) system with DSP-4 exacerbates AD-like neuropathology and cognitive impairment. However...

alz-journals.onlinelibrary.wiley.com

Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃) Find the paper here: www.nature.com/articles/s41...

Excited to share our new paper: We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory. www.cell.com/neuron/abstr...

A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall

Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

cell.com

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

Publication of the Year Award - Nomination

Thank you for submitting your Nomination!

alz.surveymonkey.com

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

'Robust circular cluster-based statistics for respiration-brain coupling' New preprint, and what a way to welcome @teresaberther.bsky.social to the #neuroskyence community. With @eliobalestrieri.bsky.social, she developed CBPT for circular #bodybrain analyses. Paper: osf.io/preprints/ps... 🧵🔽

Our paper and research on a #taVNS #MRI setup has now been published: onlinelibrary.wiley.com/doi/10.1111/... @nbkroemer.bsky.social @glassybrain.bsky.social

Mareike Ludwig@cogneuroludwig.bsky.social · 2y ago

#TaVNS inside the MR scanner IS POSSIBLE! ⚡🧠 I hope that this paper and its guidance on the taVNS MRI set-up will help those planning concurrent #fMRI and #vagusnervstimulation Checkout our new preprint osf.io/preprints/ps... Endless gratitude to @nbkroemer.bsky.social & @glassybrain.bsky.social

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...

biorxiv.org

Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...

Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience

Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...

nature.com

At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems! 🗓️Sept 19, 🕚11:45 am 🏫Room Sé #ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence

We showed previously that chemogenetic activation of the LC rescues spatial reversal learning in the TgF344-AD rat. New paper follows up and reports that optogenetic stimulation of LC terminals in CA1 also rescues cognitive deficits in 3xTg mouse model of AD. link.springer.com/article/10.1...

Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer’s disease mouse model - Psychopharmacology

Rationale One of the earliest changes associated with Alzheimer’s disease (AD) is the loss of catecholaminergic terminals in the cortex and hippocampus originating from the Locus Coeruleus (LC). This ...

link.springer.com

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

New study out in Nature Medicine: Education does not protect against age-related decline of memory. Read more here: Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries www.nature.com/articles/s41...

Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries - Nature Medicine

In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-li...

nature.com

Great (and lots of) work from Mike David and many colleagues using #pupillometry #EEG #MRI to understand arousal and #locuscoeruleus changes in #AlzheimersDisease. Out now in @braincomms.bsky.social academic.oup.com/braincomms/a...

Pupil-linked arousal, cortical activity, and cognition in Alzheimer’s disease

Combining pupillometry, EEG and MRI, David et al. report abnormalities in tonic and phasic arousal in Alzheimer’s disease. Locus coeruleus integrity, peak

academic.oup.com

Beyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out! This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵 www.science.org/doi/10.1126/...

Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety

Endogenous neuropeptide Y signaling modulates locus coeruleus activity, promoting adaptive responses to stress.

science.org

Our oscillations consensus paper is finally out as a preprint 🤩 thanks to everyone involved arxiv.org/abs/2507.15639

Brain rhythms in cognition -- controversies and future directions

Brain rhythms seem central to understanding the neurophysiological basis of human cognition. Yet, despite significant advances, key questions remain unresolved. In this comprehensive position paper, w...

arxiv.org

SCONe - Scottish-EU Critical Oscillations Network@scone-neuro.bsky.social · last yr.

/1 We took our sweet time (~3yrs) to put this into its final shape - but happy to say that the pre-print of an extensive review of brain rhythms in cognition - from a cognruro perspective - is now available. Please let us know what you think. #neuroskyence doi.org/10.48550/arX...

Call For Papers! Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch ⏰Deadline: Aug. 30, 2025 alz-journals.onlinelibrary.wiley.com/hub/journal/...

Alzheimer's & Dementia

Deadline for submissions: Saturday, August 30 2025

alz-journals.onlinelibrary.wiley.com

Super happy to see our latest work out in @plosbiology.org : N2 sleep during short naps increased the likelihood of insight in a decision task. The steepness of the spectral slope best predicted insight, beyond sleep stages alone. With dream team @maritpetzka.bsky.social @nicoschuck.bsky.social

PLOS Biology@plosbiology.org · last yr.

That "Aha!" moment... Can sleep facilitate memory reorganization? @nicoschuck.bsky.social @anikaloewe.bsky.social @maritpetzka.bsky.social &co reveal that N2 #sleep (but not N1) increases likelihood of having an 'aha' moment about a previous #DecisionMaking task @plosbiology.org 🧪 plos.io/4k8F2v3

Pulsed taVNS elicits pupil dilation. However, if sham feels as intense, there is not much left. Based on our comparatively large sample (94 participants, single-blind crossover), we show that a highly variable sham response explains this. #neuroskyence 🩺 www.biorxiv.org/content/10.1...

After years of hard work, @hashimsat.bsky.social's big one is out! Huge thanks to co-authors Katharina Wille, Matt Nassar, Radek Cichy, @nicoschuck.bsky.social & Peter Dayan - and to @haukeren.bsky.social for his invaluable support!

Muhammad Hashim Satti@hashimsat.bsky.social · last yr.

🚨 New preprint alert! Our project investigating the effects of internalizing and trait anxiety on learning under uncertainty is finally online 🐆🐅 www.biorxiv.org/content/10.1...