@NicoliLab
@nicolilab.bsky.social
RNA, Cell Biology, Zebrafish, Development Lovers
Check out my preprint highlight @prelights.bsky.social on the amazing work by @mardakheh.bsky.social and team! A pre-rRNA positive feedback loop drives malignant ribosome biogenesis prelights.biologists.com/highlights/a...
A pre-rRNA positive feedback loop drives malignant ribosome biogenesis - preLights
Tumor-driving signals turn pre-rRNA into a recruitment hub for the enzyme CK2, boosting nucleolar fusion and ribosome production
prelights.biologists.com
Very pleased to finally share the main story from my PhD, now published in @natcomms.nature.com ! 🎉 Using a sea anemone we discovered and characterised epithelial cell extrusion as the mechanism underlying starvation-induced cell loss. 🔗 Open-access article: www.nature.com/articles/s41...
Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone - Nature Communications
Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...
nature.com
New preprint alert!!! Super proud to finally share an authentic 'tour-de-force' from the amazing PhD students Shivani Gunnan @shivanigunnan.bsky.social, Max Kotz and Lucas Ribas, in collaboration with @friedrich-group.bsky.social 👇a small thread www.biorxiv.org/content/10.6...
Developmental growth rates adapt to enable self-correction of organ morphology after injury.
Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...
biorxiv.org
A resource of human RNA-protein associations is produced using a sequencing-based method go.nature.com/4gmf1Ii rdcu.be/fxFn1
Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology
A resource of human RNA-protein associations is produced using a sequencing-based method.
go.nature.com
[Job] Assistant Professor-Biology, Department of Biology, The College of New Jersey, Ewing Township, NJ #zebrafish
Assistant Professor-Biology, Department of Biology, The College of New Jersey, Ewing Township, NJ - Jobs - Confluence
zfin.atlassian.net
Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...
Editorial and peer review dynamics at elite general science journals
Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.
science.org
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins doi.org/10.1093/nar/...
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz
doi.org
A huge congratulations to Zheng and the entire Guo lab for this beautiful story! Very cool mechanism! www.nature.com/articles/s41...
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...
nature.com
An analysis in #ScienceAdvances provides new information about how both fetal and maternal cell processes contribute to preeclampsia over time, and may suggest potential therapeutic targets. https://scim.ag/4ho5LWA
Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation
Fetal and maternal contributions to severe preeclampsia unraveled in space and time with single-cell and spatial transcriptomics.
scim.ag
www.nature.com/articles/s41...
Resolving endogenous protein organization in cells with nanometer resolution - Nature Communications
Eilts and colleagues combine a double-homogenisation expansion microscopy approach with dSTORM, revealing molecular details of endogenous protein complexes, including microtubules, clathrin lattices a...
nature.com
☕ @themispa.bsky.social , Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human proteins. www.nature.com/articles/s41...
Evolutionarily conserved short linear motifs drive actin filament binding - Nature Cell Biology
Paraschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...
nature.com
☕Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration. www.nature.com/articles/s41...
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
nature.com
🥂 Yao, Li, Gai et al. profile normal coronary artery, early and advanced coronary atherosclerosis human samples with scRNAseq: they identify a progenitor-like endothelial subtype with functional implications in disease progression. 👉 rdcu.be/fwFme #Academicsky www.nature.com/articles/s41...
Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression - Nature Cell Biology
Yao, Li, Gai et al. profile normal coronary artery and early and advanced coronary atherosclerosis samples from humans using single-cell transcriptomics and identify a progenitor-like endothelial subt...
nature.com
Janssen, Angulo-Urarte, et al. @huveneerslab.bsky.social @uva.nl show that nanoscale membrane curvatures at asymmetric endothelial cell–cell junctions serve as a scaffold to recruit BAR proteins, including BIN1 and SNX9, during collective migration. rupress.org/jcb/article/...
Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...
The heart has a mysterious and complex nervous system of its own. Scientists are starting to reveal its secrets go.nature.com/4yEFk5e
The heart has a ‘little brain’ — and it protects against stress
Nature - A subset of cardiac neurons keep the heart from malfunctioning in stressed mice.
go.nature.com
A Review in Nature Reviews Genetics outlines the genetic underpinnings of retinal and macular degeneration increasingly revealed by technological advances, while also highlighting mechanistic patterns that can inform therapeutic intervention to restore vision. go.nature.com/3T8jAhY 🧬🧪
"The importance of a model is choosing one that allows you to address the question that you’re setting out to address." Sage advice from Prof. Judith Eisen (University of Oregon), Pioneer of Zebrafish Research & 2024 George Streisinger Award Winner. #ZebrafishFunFacts 🧪
🤩🤩🤩It was a pleasure & a lot of fun, as always, to work with @jcellsci.bsky.social on this - congratulations on a fantastic issue all about the #nucleus 😎😎😎
Journal of Cell Science@jcellsci.bsky.social · 2w agoWe spoke to Kate @katemiro.bsky.social about her ‘random walk’ into cellular biophysics, how AI might uncover links between nuclear morphodynamics and cell fate hiding in plain sight, and fishing for crayfish as a child growing up in Kazakhstan. journals.biologists.com/jcs/article/...
Cell biology: Cytoplasmic rivers carry molecular cargo: Current Biology www.cell.com/current-biol...
Cell biology: Cytoplasmic rivers carry molecular cargo
Molecules in the cytoplasm of an animal cell move by diffusion, motor activity, and/or fluid flow. A recent study demonstrates how directed, but often subtle, cytoplasmic drift currents carry cytoskel...
cell.com
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
Yasuda et al. report that mitochondrial hyperfusion promotes BAX-dependent release of mitochondrial RNA into the cytosol. This is associated with activation of RIG-I-MAVS-dependent innate immune signaling; suggesting a mechanism linking altered mitochondrial dynamics to RNA-sensing immunity.
dlvr.it
1/2 chameleon & human embryos exhibit an epiblast lumen before #gastrulation initiates. However, they reach this stage via different mechanisms. Our new study @natcomms.nature.com explores early development & lumenogenesis in the veiled chameleon. #evodevo #devbio www.nature.com/articles/s41...
Epiblast lumenogenesis is not a mammalian-specific trait - Nature Communications
Weberling et al. characterise veiled chameleon pre-oviposition development from fertilisation to the initiation of gastrulation and show that pre-gastrulation lumenogenesis occurs via a purse string m...
nature.com
I am excited to open my lab at @ibioillinois.bsky.social in Spring 2027! We will use zebrafish & other fishy friends to reveal the genetic basis of large scale changes in the vertebrate body plan, and how this impacts both human health and evolution. Join me at UIUC! 🧬🧫🔬 www.hawkinslaboratory.com
The heart has a mysterious and complex nervous system of its own. Scientists are starting to reveal its secrets go.nature.com/4wl3z70
The heart has a ‘little brain’ — and it protects against stress
A subset of cardiac neurons keep the heart from malfunctioning in stressed mice.
go.nature.com
In Science, researchers detailed a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. https://scim.ag/4puIuEt #WorldBrainDay
A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution
To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic mi...
scim.ag
☕Zollo et al. examine DRP1 behavior at mitochondria: DRP1 diffuses along #mitochondria in helical-like patterns influenced by MID49/MID51, scanning the organelle surface and stalling at preconstricted fission sites. www.nature.com/articles/s41...
DRP1 and MID49 co-diffusion scans mitochondria for fission - Nature Cell Biology
Zollo et al. examine DRP1 behaviour at mitochondria: DRP1 diffuses along mitochondria in helical-like patterns influenced by MID49/MID51, scanning the organelle surface and stalling at preconstricted ...
nature.com
☕Wang, Liang et al show that the #TEAD1 transcription factor can organize micrometre-sized nuclear #BiomolecularCondensates independently of active transcription. TEAD1 condensates may act as depots for excess TEAD1. www.nature.com/articles/s41...
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells - Nature Cell Biology
Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as d...
nature.com
RNA modifications - noncanonical caps, m6A, and pseudouridine - form a dynamic regulatory layer governing RNA fate across plant and animal development. Chen, Hu, Jia, Yi & Zhu review their mechanisms, detection, and therapeutic potential 🧬 www.cell.com/developmenta...
Noncanonical caps, m6A, and Ψ RNA modifications in plant and animal development
In this review, Chen et al. discuss how three types of RNA modifications—noncanonical caps, m6A, and pseudouridine—regulate animal and plant development. Elucidating the underlying mechanism and funct...
cell.com
🐙 Octopuses appear to have evolved a ribosomal innovation that increases protein translation fidelity. *suggests that evolution can tune core components of the proteostasis machinery, extending adaptation beyond gene regulation www.biorxiv.org/content/10.6...
Evolution of a core ribosomal innovation in octopus
Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and soph...
biorxiv.org
How do mechanical forces drive cancer progression? Ivaska, Sale & Yap review how tumours hijack epithelial mechanosignalling - from actomyosin tension and ECM stiffness to jamming–unjamming transitions - and what this means for therapeutic targeting 👉 shorturl.at/zBp2J
