@nipagh.bsky.social
Ph.d. in immunolgy. T cells, tetramers, DNA barcodes, Espresso Martini, and the Tank/Healer in my local DnD group. 🇩🇰🏳️🌈.
Why Is MS a More Frequent Complication of EBV Infection in Females? onlinelibrary.wiley.com/doi/10.1111/...
Why Is MS a More Frequent Complication of EBV Infection in Females?
Multiple sclerosis (MS) is a T helper (Th) cell-mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the ...
onlinelibrary.wiley.com
Preprint: B-cell depletion therapy in multiple sclerosis reduced EBV viral load and was coupled to a pronounced reduction in CD8+ T cell responses to all lytic EBV antigens www.researchsquare.com/article/rs-9...
Online now: Memory T cell aging and rejuvenation
Memory T cell aging and rejuvenation
Aging profoundly alters memory T cell immunity, reshaping diversity, differentiation, and function. Adamo et al. review how intrinsic aging programs, antigenic experience, and tissue context shape T cell responses and discuss emerging strategies to recalibrate memory T cell immunity in later life without compromising immune balance.
dlvr.it
A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra. Use our R package and get higher quality spectral data, easy as that! www.biorxiv.org/content/10.1...
Unique and interactive effects of race/ethnicity, genetics, herpesviruses, age, and gender on immunophenotypes @cp-cellrepmed.bsky.social @fredhutch.org @pgtimmune.bsky.social www.cell.com/cell-reports...
Review @natrevimmunol.nature.com Renaissance of antiviral CD8+ T cell immunity in vaccination and disease www.nature.com/articles/s41...
This is one of the most interesting developments as it appears that authors are now submitting preprints earlier in the process. A reminder that our data suggests that the best time to post is approx 1 month prior to journal submission (which ~30% now are).
Richard Sever@richardsever.bsky.social · 5mo agoSo when do authors preprint? Many do long before they submit to a journal (to get feedback to improve the work?); many submit around the same time (just want the work out?). Only a minority are submitting once the paper is under review [evidence against claims by some detractors]. 3/n
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory @natimmunol.nature.com www.nature.com/articles/s41...
💀wtf!? "" .. the last time they paid the annual maintenance fee on it was 2018! You can even find a letter where their lawyers send a refund request for the 2017 maintenance fee ($250) because Novo apparently wanted some more time to see if they wanted to pay it... "" www.science.org/content/blog...
Novo Nordisk's Canadian Mistake
science.org
.@slavov-n.bsky.social on cell size vs cell count in the human body. Lots of white blood cells in number, lots of adipocytes (fat) in volume.
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease @sciimmunology.bsky.social www.science.org/doi/10.1126/...
Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease.
science.org
Our fresh and still-steaming Journal of Clinical Investigation preprint is out! 🚀 We explore how T-cell acute lymphoblastic leukemia (T-ALL) exploits inflammatory CXCR3–CXCL10 signaling within the meninges to drive CNS infiltration. www.jci.org/articles/vie...
JCI - T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges
jci.org
A very interesting read. I wonder how one could replicate this in other autoimmune disorders. www.nature.com/articles/s41...
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes - Nature Immunology
The authors identify a Cys→Ser transformation (C19S) in insulin leading to neoepitope presentation and CD4⁺ T cell autoreactivity in type 1 diabetes. Inflammation and oxidative stress enhanced C19S tr...
nature.com
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshcha...
cell.com
Our new paper is out in Nature - online today! Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators. 📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
nature.com
Sunday reading. I aspire to write something like this for T cells one day. www.cell.com/immunity/ful...
A roadmap for defining “extrafollicular” B cell responses
The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes...
cell.com
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
Me as a PhD student:"I hate how useful this is". Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete? Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells. www.biorxiv.org/content/10.1...
TCR activation impairs CAR-T cytotoxicity against separate target cells
Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...
biorxiv.org
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ... In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. In this essay: (1) why blog, (2) what to blog about, (3) how to get started, and (4) using AI. https://doi.org/10.59350/bqnfd-7p249 🧪
Technical blogging for growth and learning
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. This post: why blog, what to blog about, how to start, and using AI.
doi.org
Double negative T cells can act as professional APCs capable of tolerance induction? How fascinating - I'm picturing a western stand-off between two T cells (both equipped with granzymes btw) unwilling to let go of the other!
Waggoner Lab@labwaggoner.bsky.social · last yr.Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice @natcomms.nature.com www.nature.com/articles/s41...
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice @natcomms.nature.com www.nature.com/articles/s41...
Autoantibodies against cytokines, growth factors, immunoreceptors, & tumor surface proteins robustly modulate immune checkpoint inhibition therapy response @aaronmring.bsky.social @nature.com www.nature.com/articles/s41...
