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Raaj Gowrishankar

@outraajeous.bsky.social

Neurobiology of motivated behavior. Assistant Professor, MUSC | Postdoc, UW | Ph.D., Vanderbilt. he/him 🌈 http://www.raajgowrishankarlab.org/

40 Posts459 Follower392 Folgt
Blake Richards@tyrellturing.bsky.social · last wk.

Super cool paper here, showing that the cerebellum has a credit assignment mechanism solving the weight transport problem and giving every P-cell the right error signal! But, could the neocortex be the same? Could it possibly be hard-wired like this? I suspect not... Mystery to solve! 🧠📈 🧪

Reza Shadmehr@rezashadmehr.bsky.social · last wk.

If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...

Andrew Hardaway@andrewhardaway.bsky.social · 2w ago

Calcitonin Gene-Related Peptide (CGRP)-Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1 onlinelibrary.wiley.com/doi/10.1111/...

Calcitonin Gene‐Related Peptide (CGRP)‐Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1

Proportion of calcitonin gene-related peptide (CGRP)-positive terminals expresses synaptic or perisynaptic postsynaptic glutamate delta 1 (GluD1) immunoreactivity at symmetric and asymmetric synapses....

onlinelibrary.wiley.com

Wendy Xin@droligo.bsky.social · 4w ago

Our review on glial orchestration of neurodevelopment is online at @cp-devcell.bsky.social! Great fun working with Krissy Sakers and Pat Sheehan from the Eroglu and Schafer labs, and special thanks to first author Krissy for her tremendous work bringing this to fruition! www.cell.com/developmenta...

Glia orchestrate neural circuit development

In this review, Sakers et al. discuss how astrocytes, microglia, and oligodendrocyte lineage cells actively regulate neural circuit formation, refinement, and stabilization. They propose that coordina...

cell.com

Alex Galvez-Pol@alexgalvezpol.bsky.social · last mo.

New preprint out now. 🎭 What makes an acted emotion feel believable? We tested whether believability depends on what observers see from the outside, facial movement, and what happens inside the actor’s body, cardiac dynamics during performance. doi.org/10.64898/202...

Actors' Facial Movement Magnitude and Cardiac Dynamics Predict Observers' Emotion Believability Ratings

In non-verbal communication, observers infer emotions from visible facial movements, yet emotional experiences are described in internal bodily terms (e.g., "my heart skipped a beat"). This contrast h...

doi.org

Aaron Milstein@neurosutras.bsky.social · last mo.

Excited to share this preprint from @ianoldenburg.bsky.social . To evoke movement with holo stim, you need the right pattern at the right time! Interestingly, the preparatory state before spont motion is not the same as the state permissive for evoked motion. Dig in! www.biorxiv.org/content/10.6...

The Importance of Synchrony in the Neural Control of Movement

Throughout the mammalian cortex, populations of neurons must work together to enact behaviors. While population recordings in motor cortex have revealed many aspects of when neurons fire during behavi...

biorxiv.org

Vidita Vaidya@viditavaidya.bsky.social · last mo.

Excited to see this study from @darshanakapri out in @npp_journal showing norepinephrine regulates mitochondria within hippocampal neurons via a β2-AR–Gs-cAMP–PKA-PGC-1α cascade, suggesting links between NE effects on mitochondria and cognition. www.nature.com/articles/s41...

Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α - Neuropsychopharmacology

Neuropsychopharmacology - Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α

nature.com

Nicole Rust@nicolecrust.bsky.social · last mo.

Really wise (and delightful) *DO NOTs* for speaking. Among my favorites: "Design your talk so that <30% of the audience understands it". Even if your discoveries are very important, that's bad. Value = f(discovering stuff, explaining that stuff coherently). 🎯.

Itai Yanai@itaiyanai.bsky.social · last mo.

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

Daniel Castro@flanbrain.bsky.social · 2mo ago

First Castro Lab paper, brought to you by the hard work of Dr. Kathryn Braden @katybraden.bsky.social In this manuscript we investigate the role of endogenous enkephalin or dorsal raphe nucleus. We find that it is incredibly important for buffering negative affect 😱 www.nature.com/articles/s41...

Dorsal raphe nucleus enkephalin peptide modulates behavioral preference - Neuropsychopharmacology

Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference

nature.com

Julian Meeks@meeksandmilds.bsky.social · 3mo ago

New preprint from the lab! Most mammals have a secondary olfactory system (accessory olfactory system, a.k.a. vomeronasal system) that provides extra information about social cues that aren't airborne. This system is especially sensitive to "messy things" (saliva🤤, tears😿, urine🚾, feces💩) (1/n)

Bile acid chemosensation in mammals supports species and gut microbiome evaluation

The rodent accessory olfactory system (AOS) detects chemosignals emitted by conspecifics and other species to support beneficial behaviors. Peripheral vomeronasal sensory neurons (VSNs), the AOS' chemical sensors, detect fecal bile acids in patterns that have unknown significance to the animal. We used a combination of mass spectrometry and VSN calcium imaging to investigate the AOS' capacity to use bile acid information to discriminate between fecal samples from captive reptiles and mice with varying gut microbiome states. Mass spectrometry analysis revealed bile acid patterns that distinguished biologically relevant samples from one another, representing theoretical discrimination axes. We measured VSN response patterns to bile acid stimuli aligned with theoretical discrimination axes. We found that VSNs perform stimulus "whitening" via an inverse relationship between natural bile acid abundance and population response magnitude. VSNs showed maximum sensitivity to taurine-conjugated bile acids, which have high theoretical discriminatory value, but were found at low natural abundance levels. Individual taurine-conjugated bile acids drove threat assessment behavior when added to familiar mouse fecal extracts, suggesting high behavioral significance. Finally, we analyzed the degree to which the AOS utilizes the theoretical information about species, diet, and gut microbiome status from bile acids. We found that VSN tuning patterns align with theoretical axes for discriminating reptilian predators from vegetarians, and between mice with different gut microbiome states. VSN tuning was especially well-aligned with the information available about conspecific gut microbiome status. These results show that AOS bile acid chemosensation supports discrimination of multiple biologically relevant states. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, R01DC017985, R56DC015784, R01DC021213

biorxiv.org