Models of hyperglycaemia in diabetes mellitus and its complications - Nature Reviews Endocrinology

Many different models are used in research into diabetes mellitus, and each has strengths and limitations. In this Review, the authors explain several in vivo and in vitro models of hyperglycaemia and...

nature.com

Let the data speak — single-cell analysis with CellWhisperer

Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00927-xIn this Tools of the Trade article, Moritz Schaefer introduces CellWhisperer, a multimodal machine learning model and software tool for the chat-based interrogation of single-cell RNA sequencing datasets.

nature.com

Conferences & Schools – 2026 – Gene Regulation – Teif Lab

generegulation.org

SET1/MLL complexes control transcription independently of H3K4me3

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

biorxiv.org

Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing

Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...

biorxiv.org

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia

Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

keysym.us

Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics

In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

nature.com

FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics

The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

network.febs.org

FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate

Burgos-Bravo et al. use single-molecule optical tweezers to monitor the effect of the histone chaperone FACT on transcription through nucleosomes. FACT functions on nucleosomes initially unwrapped by ...

cell.com

High-throughput transcriptome analysis reveals a developmental increase in Acvr1c which mediates epigenetic repression of the gene encoding the pubertal brake, Makorin ring finger protein 3

Abstract. Makorin ring finger protein 3 (MKRN3) acts as a “pubertal brake.” MKRN3 loss-of-function mutations are the most common genetic cause of central p

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Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch

Nature Chemistry - Dynamic gene expression is crucial for coordinating diverse cellular activities, but challenging to modulate with high spatiotemporal precision. Now, a photoswitchable DNA...

rdcu.be

The R Graph Gallery – Help and inspiration for R charts

The R graph gallery displays hundreds of charts made with R, always providing the reproducible code.

r-graph-gallery.com

First map of human brain mitochondria is ‘groundbreaking’ achievement

Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

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CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks - Nature Communications

Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&T...

nature.com

G-quadruplexes and their unexpected ability to fold proteins | PNAS

G-quadruplexes and their unexpected ability to fold proteins

pnas.org

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex

Many genes physically interact with the nuclear pore complex (NPC), which requires transcription factors (TFs). Ge et al. show that the exportin Crm1 binds TFs and nuclear pore proteins to dock chromatin at the NPC and to stimulate transcription. This function of Crm1 is distinct from its role in nuclear export.

dlvr.it

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice - Nature Neuroscience

Studying GnRH neuroendocrine cells in the mouse olfactory bulb (GnRHOB neurons), Decoster et al. show that these cells respond to female odors and their activation regulates males’ female-odor prefere...

nature.com

Short-term evolutionary implications of an introgressed size-determining supergene in a vulnerable population

Nature Communications - The thorny skate is a vulnerable species in the northwest Atlantic ocean with a discreet size polymorphism. Here, the authors have sequenced 49 thorny skate individuals,...

rdcu.be

Women twice as likely to develop Alzheimer's disease as men - but scientists do not know why - Nature Medicine

Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.

go.nature.com