Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu

Nature@nature.com · 3mo ago

Nature research paper: A critical initialization for biological neural networks go.nature.com/4tRNjIu

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

1️⃣ 🥳 Thrilled to share that my postdoc work has finally hit the press! www.nature.com/articles/s41... When we started, we didn’t really know what PVH-MC4R neurons do in obesity. Are they still signaling or “dead”? (e.g., does the chronically high leptin alter α-MSH–MC4R signaling?) 🧵👇

Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons - Scientific Reports

Scientific Reports - Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons

nature.com

Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧. We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs. www.researchsquare.com/article/rs-6...

Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

Featuring 2p FLIM to track DA levels over days, and a demonstration that a neurons molecular identity is pretty labile @stephen-zhang.bsky.social @markandermann.bsky.social P.S: Praneel will be applying to MD PhD and is an absolute beast. Systems neuro labs don’t miss out!!

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

Wild! Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

Praneel's study shows that two temporally complementary mechanisms, neuronal excitability and neurotransmitter composition, jointly control dopamine release and mating drive over days. Praneel is a dedicated, mature, and wholesome student on his way to becoming a physician scientist.

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days

The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...

biorxiv.org

We've had advances in green genetically encoded Ca2+ indicators (GECIs), but what about red-shifted GECIs? @piatkevich.bsky.social &co present SomaFRCaMPi, a new soma-localized red #GECI that exhibits improved accuracy & sensitivity for in vivo neuronal imaging @plosbiology.org 🧪 plos.io/3YnCqRW

Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63

A hypothalamic circuit underlying the dynamic control of social homeostasis

Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

rdcu.be

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Sign the Petition

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it

A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo. It works well with wide-field imaging, two-photon microscopy, and fiber photometry biorxiv.org/content/10.1...

Very good, concise summary of the gut-brain axis of communication and interoception www.cell.com/current-biol... open-access

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...

Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3

Stochastic neuropeptide signals compete to calibrate the rate of satiation

Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...

rdcu.be

We wrote a review on analysis methods for large-scale neural recordings www.science.org/stoken/autho... @marius10p.bsky.social #neuroscience 🧪🧠 Anything we missed? Reply w/ your fav method!