Cilia alert! Last year Juyeon Hong described a new domain in 9+2 cilia called the EDT, the extreme distal tip. Now, she's found a new protein required for its assembly, but only in non-mammalian vertebrates. A cool evo-cell / protein evolution story in @cellreports.bsky.social tinyurl.com/2xvdskx6

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...

Septins and cytokinesis in the polymorphic fungus Aureobasidium pullulans rupress.org/jcb/article-...

Septins and cytokinesis in the polymorphic fungus Aureobasidium pullulans

Budding yeasts are thought to use septins to mark mother–bud necks as sites for cytokinesis. Here, Colarusso et al. find that the multibudding yeast Aureob

rupress.org

www.biorxiv.org/content/10.6... Sol-gel Transition Drives Hyper-fast Mixing in a Giant Cell super cool work on longstanding question about gel-sol transitions in cells using the giant amoeba Chaos carolinensis! @wallaceucsf.bsky.social

From single-celled organisms to ciliated epithelia in metazoans, precise positioning of basal bodies (BBs), which anchor motile cilia, is essential for generating fluid flows. Here, I, @raghavan-thiaga.bsky.social, will take you on a brief tour of how cells build this spatial organization.

My grad student Oz and I are very excited to share our new work, Differentiable Design for Morphogenesis www.biorxiv.org/content/10.6... (waxMorph)

Dynein-microtubule forces drive nucleokinesis and transmigration in T cells www.biorxiv.org/content/10.6...

📢Check out our latest preprint list on FocalPlane In this list, we focus on the latest tools and techniques in imaging, including sample prep, probes, hardware and software. focalplane.biologists.com/2026/06/26/m... Let us know if you've been reading a preprint that we should add to our list.

Microscopy preprints – new tools and techniques in imaging - FocalPlane

Microscopy preprints – new tools and techniques in imaging - News

focalplane.biologists.com

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

Tateishi, K., Nishida, T., Inoue, K., & Tsukita, S. (2017). Three-dimensional organization of layered apical cytoskeletal networks associated with mouse airway tissue development. Scientific reports. #EpithelialMechanics doi.org/10.1038/srep...

Kunimoto, K., Yamazaki, Y., Nishida, T., Shinohara, K., Ishikawa, H., Hasegawa, T., ... & Tsukita, S. (2012). Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell, 148(1), #EpithelialMechanics doi.org/10.1016/j.ce...

Kunimoto, K., Yamazaki, Y., Nishida, T., Shinohara, K., Ishikawa, H., Hasegawa, T., ..., Tsukita, S., & Tsukita, S. (2012). Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell, 148(1-2), 189–200. #EpithelialMechanics doi.org/10.1016/j.ce...

New research from #JRSocInterface: Closed-loop control of the small intestinal transport within an integrated mechano-physiological framework doi.org/10.1098/rsif... | #Biophysics #ChemicalEngineering #ComputationalBiology

Articles in our new #Microtubules collection explore how #kinesins coordinate stepping behavior during transport or generate mechanical stress, as well as mechanisms underlying #dynein activation. New research to accompany @embo.org @embl.org Workshop: 👉 rupress.org/jcb/collecti... #EESMicrotubules

Centriolar cap proteins CP110 and CPAP control slow elongation of #microtubule plus ends. From Saishree Iyer, Anna Akhmanova and colleagues: rupress.org/jcb/article/... 📕 Part of our #Microtubules collection: rupress.org/jcb/collecti... #EESMicrotubules

Getting nuclear size just right – emerging mechanisms regulating nuclear scaling and morphology @jcellsci.bsky.social journals.biologists.com/jcs/article/...

New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc

Structure of the mammalian ciliary transition zone microtubule doublet

The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...

tinyurl.com

Every 3D tissue is a map waiting to be drawn. Flatten a curved tissue, follow how it deforms, find its hidden axis, or measure its shape to explain how it moves: it's all cartography!

Our new paper in @plosbiology.org introduces IntAct-U-ExM enabling isoform-specific imaging of actin at nanoscale across yeast, mammalian cells & primary neurons. Fabulous work spearheaded by @anubhavdhar.bsky.social along with an amazing team! #actin #U-ExM journals.plos.org/plosbiology/...

In their Cell Science at a Glance article, @zeinabrekad.bsky.social Stavroula Mili, Ellen Van Obberghen-Schilling & Delphine Ciais highlight the ways in which RBPs & local RNA regulation impact adhesion-dependent processes, & the effect of their dysregulation. journals.biologists.com/jcs/article/...

How does a relatively simple tube become a complex brain? 🧠 One of the most dramatic transformations in development! We built a framework to map exactly what changes. 🧵 New preprint from my postdoc at @nerurkar.bsky.social lab: doi.org/10.64898/202...

Opposing actomyosin pools establish epithelial polarity during naive pluripotency exit rupress.org/jcb/article-...

Opposing actomyosin pools establish epithelial polarity during naive pluripotency exit

Shi, Manzi et al. demonstrate that in polarizing epithelial spheroids from mouse embryonic stem cells, ZO-1 clusters are transported by cortical flows to e

rupress.org

"we trace self-organization from evolutionary origins to biophysical inevitability and discuss how emerging tools in stem cell biology and bioengineering are beginning to translate these insights into regenerative strategies." 🌐 🧪 🦠 www.nature.com/articles/s41...

Decoding the origins of cellular self-organization for engineered biology - Nature Biotechnology

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance ...

nature.com

Cell fusion after wounding requires plasma membrane damage and endocytosis https://www.biorxiv.org/content/10.64898/2026.05.31.728998v1

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues www.nature.com/articles/s41... #physics

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues - Nature Physics

Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.

nature.com

This is my first paper. A brief introduction of myself.

Yuki Maekawa@gatohamu.bsky.social · 2mo ago

www.pnas.org/doi/10.1073/...

An optopharmacological tool for on-demand perturbation of branched actin polymerization www.biorxiv.org/content/10.6...

sorry, here are working links for the 2nd Asian Xenopus Conference: www.xenbase.org/xenbase/doNe... 2026.xenopus-asia.org #science #devbio #cellbio #xenopus #frogs