BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

"Imagine if we can apply the same approach across the entire world and start to map to capture the true diversity of the human immune system so we can build predictive models and figure out interventions." 🔆 Don't miss David Ewing Duncan's new substack: davideduncan.substack.com/p/welcome-to...

Welcome to the Human Immunome—Conversations with Systems Immunologist John Tsang and Human Immunome Project Chair Jane Metcalfe

John and Jane are key subjects in my new investigative article for MIT Tech Review and Aventine. The column offers more details and musings on recent dramatic breakthroughs in immunomics

davideduncan.substack.com

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

cell.com

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

@biorxivpreprint.bsky.social STAT3 operates as an inflammation-dependent transcriptional switch @josephsunlab.bsky.social @simongrassmann.bsky.social @mskcancercenter.bsky.social www.biorxiv.org/content/10.1...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Research Specialist A/B

University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

wd1.myworkdaysite.com

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

nature.com

One more thing to mention: we are thrilled to be joining the vibrant and growing Systems Immunology community here, led by @tsanglab.bsky.social. There will be much collaborative work with the vision of understanding and rebuilding the immune system from the ground up, so stay tuned!

The Kueh lab@kuehlab.bsky.social · last yr.

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology. medicine.yale.edu/systems-engi...

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology. medicine.yale.edu/systems-engi...

Research

The immune system is a spatially distributed, whole-body sensory-reactive system that monitors, reacts, and adapts to various stress signals (e.g., tissue

medicine.yale.edu

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

Science Magazine@science.org · last yr.

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. Learn more: scim.ag/3IYhnk7

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

Identification of proliferating neural progenitors in the adult human hippocampus

Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

science.org

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social www.pnas.org/doi/10.1073/...

First Phase 2 randomized trial of engineered T cells for a solid tumor—GI cancer— with some encouraging results www.thelancet.com/journals/lan... @thelancet.com

🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.

(1/n) New preprint from @claricehongky.bsky.social Fan Fang Varshini Ramanathan in collab w Jie Liu. Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

@claricehongky.bsky.social · last yr.

Excited to share my first preprint from the @andersshansen.bsky.social lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think! tinyurl.com/bdfvtd6f

Check out this great resource of single cell multiome data, cell annotations, regulatory DNA models of cell type resolved chromatin accessibility & comprehensive annotation of motifs & sequence syntax for multiple tissues in early human development 1/

Selin Jessa@selinjessa.com · last yr.

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

1. For the past thirty years I've had the best job in the world. 
I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

science.org

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

Trump promised scientific breakthroughs. Researchers say he’s breaking science.

NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

wapo.st

It’s the economy stupid- “There is no better investment than one that saves lives, supports local economies and drives America’s global leadership in biomedical innovation” www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

forbes.com

Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis www.nature.com/articles/s41...

Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature

Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...

nature.com

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology

Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

nature.com

I'm going to Stand Up for Science 2025 in Seattle. Seattle friends, come join! Fri March 7. Mural Amphitheatre at Seattle Center. 305 Harrison Street, Seattle. 12-3pm PST.

Stand Up for Science!@standupforscience.net · 2y ago

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Rubio terminated 5800 USAID contracts – more than 90% of its foreign aid programs – in defiance of the courts. Here’s a list of just some of the lifesaving awards that were terminated. Nearly all were Congressionally mandated. They’ve saved millions of lives. 🧵

This is a powerful (and accurate) speech both about curiosity driven research and about which institutions would be most hurt by a 15% cap on indirect cost rates (smaller academic med centers) and who would benefit (China). 1/2

Melanie@melscott98.bsky.social · 2y ago

Thank you Rep Auchincloss. This is the best 3 min summary of why the whole of the US should be supporting research and scientific discovery. @jeremymberg.bsky.social @altnih4science.bsky.social @repauchincloss.bsky.social @faseborg.bsky.social x.com/RepAuchinclo...

Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science." "The weeks ahead may be the greatest test that the US scientific community has ever faced" By @holdenthorp.bsky.social @science.org www.science.org/doi/full/10....

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science. This helps me remember what this is all about. Ironically, it is about the treatment of pain.

the word irony is written on a white background

ALT: the word irony is written on a white background

media.tenor.com

NIH-supported research saves lives: here are two "poster" human beings to prove it. Emily Whitehead: cured of her leukemia by CAR-T developed at Penn. Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.