Vince Luca, PhD

@thelucalab.bsky.social

We use structure-guided engineering to design biologics & immunotherapies. Associate Professor of Immunology, Director - Center for Antibody & Protein Engineering (CAPE) @ Moffitt Cancer Center www.thelucalab.org

2026 has been a remarkable year for me so far (despite the current world events): opening my lab at the University of Zurich, assembling an amazing group of people in the group, and celebrating it with a fantastic lab warming party. Figured it's also time for a small profile refresh.

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I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:

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Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh!

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.

science.org

University efficiency drives may have opposite effect, study finds. The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education. www.researchprofessionalnews.com/rr-news-aust...

University efficiency drives may have opposite effect, study finds - Research Professional News

Teaching and research staff say reforms mean more red tape for them, Australian survey reports

researchprofessionalnews.com