Excited to see our report on an #INCYPRO stabilised D-stereospecific hydrolase featured on the the inside cover of the current Angewandte issue! doi.org/10.1002/anie... Congrats to all coauthors and collaborators from the Bordusa Lab and Incircular. #ProteinEngineering #Biocatalysis

We were excited to collaborate with Bruno Di Geronimo from @lynnkamerlin.bsky.social group on the stabilization of Salvia rosmarinus borneol dehydrogenase (BDH). In the preprint we explore two computational methods, put them into contrast and explore a subset of new variants. doi.org/10.64898/202...

Full-Atom MPNN Based Redesign of Plant Dehydrogenase Enables Thermostability Enhancement Without Loss of Stereoselectivity

Protein stabilization is a “Holy Grail” of biocatalysis, and stability design is an area of intense research interest. While it is increasingly feasible to effectively increase enzyme thermostability, optimization without compromising activity or selectivity remains a significant challenge. Here, we use full-atom protein sequence design with sidechain conditioning (FAMPNN) to engineer thermostable variants of the borneol dehydrogenase from Salvia rosmarinus (SrBDH1), an enzyme from a family where unselective enzymes dominate, and selectivity is determined by dynamical considerations. By combining FAMPNN design with residue conservation analysis and avoiding active site residues, we were able to computationally design SrBDH1 variants with up to 10 °C enhanced thermostability and strongly increased half-life time at elevated temperature, while retaining selectivity towards (+)-borneol. This design framework, integrating de novo and physics-based protein design tools, demonstrates that stability can be enhanced without disrupting functionally relevant dynamics, providing a route to engineer robust and selective biocatalysts.

buff.ly

We report an #INCYPRO stabilised D-stereospecific hydrolase which operates efficiently at 50°C in 10% ethanol! The article in Angewandte Chemie originates from a collaboration with the Bordusa Lab and Incircular. Congrats to all authors! #ProteinEngineering #Biocatalysis doi.org/10.1002/anie...

Recent article from the lab published in @jacs.acspublications.org. Big congrats to first author Zainab Rashid for leading the study and great collaboration with @tomngrossmann.bsky.social and Jocelyne Vreede labs!😃 doi.org/10.1021/jacs... #singlemolecule #dsRNA #RNAtherapeutics

TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding

Double-stranded RNA (dsRNA) has become an essential tool to understand biological processes with promising therapeutic implications. However, its usage is often limited due to poor cellular uptake and...

doi.org

Next up, Jannik Keyser Paulus from the group of @tomngrossmann.bsky.social in @uni-goettingen.de focussed on redox responsive peptide dimers to stabilise and release therapeutic dsRNA 1/3 #17GPS

Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry #AC pubs.acs.org/doi/10.1021/...

Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry

The function and stability of proteins depend on their three-dimensional structure, which includes conformational dynamics and potential self-assembly. Protein structural organization is particularly ...

pubs.acs.org

After a decade @vuamsterdam.bsky.social I’m excited to share that I’m starting @uni-goettingen.de‬ I’m incredibly grateful for my supportive colleagues at the VU and looking now forward to the opportunities ahead. Big THANKS to everyone in the group who supported our research over the years!

Greetings from the GRC on Artificial Molecular Switches and Motors! It’s exciting to see how the field has grown and is moving toward everyday applications—think photoswitchable tattoos!

Great to see our Highlight Review on TAV2b-derived RNA modulators online at Chemistry Letters doi.org/10.1093/chem... Congrats to first author Marvin Albers! Read more about our RNA-targeting strategies also here: -> doi.org/10.1002/anie... -> doi.org/10.1093/nar/... -> doi.org/10.1002/chem...

Now that our new @jacs.acspublications.org paper is printed, let me show you what's so cool about the group B [FeFe]-hydrogenase from Thermosediminibacter oceani (ToHydA) 😎 doi.org/10.1021/jacs...

You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions? 😱🧪 Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions! onlinelibrary.wiley.com/doi/10.1002/...

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di-)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids t...

onlinelibrary.wiley.com

🚨 Hot off the press in @ChemSocRev! A must-read tutorial review on N-heterocyclic carbenes (NHCs) on surfaces. 📄 "Insights into the surface chemistry of NHCs" 👇 Dive in: pubs.rsc.org/en/content/a... #SurfaceChemistry 👩‍🔬✨

Insights into the surface chemistry of N-heterocyclic carbenes

N-heterocyclic carbenes (NHCs) have emerged as a versatile and powerful class of ligands in surface chemistry, offering remarkable stability and tunability when bound to surfaces, including metals, me...

pubs.rsc.org

Great to see our paper on helicity-dependent peptide cyclizations online at the Journal of Peptide Science doi.org/10.1002/psc.... (open access) Congrats to all authors!! #peptidomimetics

Happy to share our latest #glycotime work with Sarah, Annabelle and @mariofares.bsky.social Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections @pubs.acs.org |Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections: A Biophysical Study

Chronic lung infections caused by Pseudomonas aeruginosa and Burkholderia cenocepacia pose a severe threat to immunocompromised patients, particularly those with cystic fibrosis. These pathogens often...

pubs.acs.org

🎉 Big day for our group: our first publication is out! Tom did a fantastic job highlighting current trends & opportunities in peptide catalysis — now published in Chem Catalysis (open access). Huge congrats, Tom! www.cell.com/chem-catalys...

Peptide catalysis: Trends and opportunities

Peptides are highly selective organocatalysts, with intrinsic modularity allowing precise control over structure and function. Advances in peptide synthesis, biotechnology, and cheminformatics will en...

cell.com

Check out Nick & @roesslph.bsky.social work on nucleosome electrostatics! More to come shortly 👀 #NMRchat

NMR-Based Measurements of Site-Specific Electrostatic Potentials of Histone Tails in Nucleosome Core Particles

Electrostatics play a dominant role in guiding many biological processes. This is especially the case in the context of chromatin, where charge interactions modulate diverse activities such as DNA rep...

pubs.acs.org

One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today! www.nature.com/articles/s41...

Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature

The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...

nature.com

Hi! Our lab has moved to Bluesky! We will discontinue our Twitter presence in the near future, so please watch out our news here!

Did you enjoy the amazing #ABPP2025 meeting? Or were you sad that you could not attend? If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)

Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience

Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

nature.com

What a superb and inspiring day, discussing highly diverse aspects of #Bioinspiration - A big thank to all the speakers, chairpersons, and the attendance. As well as the people involved in the organization... Advances in Bioinspirations @inserm.fr - @cea.fr - @cnrs.fr #BMSV

Make sure not to miss our latest paper out now in #JACS - presenting eSylites - small, peptide-based probes for precise mapping of neurons, etc.! Microscale thermophoresis (MST) played a huge part in optimizing the probes structure and sequence for binding affinity. #ChemicalBiology #Synapse

Maric Lab@hmariclab.bsky.social · last yr.

🚀 Excited to share our latest work in #JACS on eSylites! —Synthetic, high-affinity #ChemicalBiology probes for #SuperResolution #Synapse visualization & precise mapping in neurons and brain slices—without the need for antibodies, tags, or transfection! 📢 Read more: pubs.acs.org/doi/10.1021/...

From the Besse's lab. #RNAbiology #RNAlocalization #spatialbiology www.nature.com/articles/s41...

Axonal RNA localization is essential for long-term memory - Nature Communications

Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...

nature.com

Wow, major breakthrough in the development of broadly neutralizing bispecific antibody therapeutics against SARS-CoV-2, led by @stanford-chemh.bsky.social institute scholar @cobarnes27.bsky.social 😃 www.science.org/doi/10.1126/...

Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern

Bispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern.

science.org

Beyond excited to announce our in-person symposium to celebrate the 25th anniversary of ChemBioChem/ChemPhysChem! Advances in Structural Analysis of Biomolecules From Subcellular Imaging to Drug Design October 23-24, 2025, Berlin Please like and share: cbc-cpc2025.org

www.nature.com/articles/d41... #RIPTACs

Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic

Halda Therapeutics has started a clinical trial of its first-in-modality RIPTAC drug HLD-0915 in prostate cancer, to see if bifunctional drugs can provide tissue-specific activity.

nature.com

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬 onlinelibrary.wiley.com/doi/full/10....

DNA Mimic Foldamer Recognition of a Chromosomal Protein

Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

onlinelibrary.wiley.com

I'm pleased to share our latest paper with our wonderful collaborators in the Lombardi lab on a biocatalyst for selective CO2 reduction: pubs.rsc.org/en/content/a...

Follow all your favorite @rsc.org journals now on Bluesky! Let the posting begin! 🥳🧪 #chemsky go.bsky.app/QAaTTZ3

It's out! Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social! Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇

Society for the Protection of Underground Networks (SPUN)@spun.earth · last yr.

Our newest research on plant-fungal trade published today in @nature.com. The work, led by scientists from Vrije Universiteit, Princeton University, SPUN & AMOLF combines robotics, mycology & biophysics to reveal underground supply-chain dynamics. Open access: www.nature.com/articles/s41...