Thrilled to share our work in @cp-immunity.bsky.social: "Resident Memory T cells in Primates Activate Humoral and Stromal Immunity." Thanks @cfi-umn.bsky.social @vgti.bsky.social @enprcnews.bsky.social, outstanding Masopust lab members and Dave Masopust! authors.elsevier.com/c/1lxK43qNrU...

🔬 The Carbone Lab is Hiring! 🔬 I'm looking for a Research Scientist I to help launch my new lab at Seattle Children's Research Institute! If you or someone you know is excited about #cancerimmunology, #microscopy, and building a lab from the ground up, apply here:

Research Scientist I - Carbone Lab in Seattle, Washington | Research at Seattle Children's

Apply for Research Scientist I - Carbone Lab job with Seattle Children's in Seattle, Washington. Research at Seattle Children's

careers.seattlechildrens.org

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

Facilities and Administrative (F&A) Costs Explainer

YouTube video by Association of American Universities

youtube.com

The Trump administration’s announced policy to cut funding for medical research grants from the National Institutes of Health (NIH) is terrible for #TX07 and for our country. My statement ⬇️

How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.

News reports on NIH cutting indirect costs may not be understood by many not dealing with science funding. To do science, you need to apply for funding. This has becomer a highly competative process. Many good ideas are not funded due to a shortage of money. www.science.org/cont... 1/9

NIH slashes overhead payments for research, sparking outrage

Move to cut indirect cost rate to 15% could cost universities billions of dollars

science.org

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm bit.ly/40NkIc0

No functional NIH…no US scientists that spend their days making discoveries that save lives and drive US innovation and economic growth. This will negatively impact all Americans.

Angie Rasmussen@angierasmussen.bsky.social · 2y ago

No study section...no grant reviews No grant reviews...no grants awarded No grants awarded...no research No research...no functional NIH

To all of my colleagues at NIH, I'm thinking of you and I'm sending all the good vibes I can muster!!! To all of my other colleagues as panicked as I am about the NIH funding that allows us to do the important research we do... We'll get through this together, somehow www.science.org/content/arti...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring

Researchers facing

science.org

Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors. Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4 Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation. 🔗 www.nature.com/articles/s41.... @ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature

Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

nature.com

Super excited to announce that the Joag Lab will officially open at @UW, @SCRI in March 2025! We will study the interplay between memory T cells and stromal, humoral, and innate immunity in mucosal tissues. researcherprofiles.seattlechildrens.org/Vineet.Joag. Hiring a technician and a postdoc!

great work from @ Jason Mitchell, @ Justin Spanier, and @ Brian Fife pubmed.ncbi.nlm.nih.gov/39214091/

CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes - PubMed

T cell-mediated islet destruction is a hallmark of autoimmune diabetes. Here, we examined the dynamics and pathogenicity of CD4⁺ T cell responses to four different insulin-derived epitopes ...

pubmed.ncbi.nlm.nih.gov

Cigarette smoke chemicals bind MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease doi.org/10.1084/jem....

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) www.science.org/doi/10.1126/...

Nutrient-driven histone code determines exhausted CD8+ T cell fates

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

science.org

Elegant work by Jason Cyster's group "Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

cell.com

39 rotations around the sun! And what a year it's been. The lab has doubled in size. We had our first (3!!!) graduate students and post docs join the lab. We had both our first and second lab papers EVER accepted - the first is out in print... so check it out -(journals.aai.org/jimmunol/art...).

Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer

Key Points. IV anti-CD45.2 label lasts for 3 days and tracks leukocyte migration to tissue.There is continuous innate and adaptive leukocyte migration in a

journals.aai.org

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity www.nature.com/articles/s43...

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging

Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...

nature.com

TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells doi.org/10.1101/2025...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential! Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs tinyurl.com/5yahn47t tinyurl.com/4n4btxap

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com t.co/xXXCJx5VYm #ImmunoSky 🧪

Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

cell.com

How are durable antibody-responses to vaccines induced? News & Views paper discussing excellent new work by Cortese et al in Nature Immunology: www.nature.com/articles/s41... Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology

#Immunology out now @science.org ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting. https://buff.ly/42iBst0