Sickle-cell disease linked to prematurely aged stem cells in mice

A combination of drugs restores stem-cell function in mouse models of the blood disorder.

go.nature.com

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

nature.com

Nitric oxide drives proteomic diversity through alternative splicing

Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.

dlvr.it

Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

nature.com

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.

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Best Practices in Demographic Data Collection for Equity, Diversity, and Inclusion in Rare Disease Research: A Systematic Review

Rare diseases affect small, dispersed populations and are often studied through multisite designs where equity-relevant demographic data are essential for inclusive recruitment and accurate interpreta...

gimjournal.org

Genotype before phenotype? Reversing the diagnostic odyssey in genomic medicine

For decades, the diagnosis of rare genetic disorders has relied on a phenotype-driven approach, often resulting in a prolonged “diagnostic odyssey.” T…

sciencedirect.com

In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging

In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, linking translational deregulation to stem cell aging.

dlvr.it

Pancreatic cancer mRNA vaccine shows lasting results in an early trial

Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

nbcnews.com

Organ formation in early human embryos captured in spatial cell atlas

Spatial maps of gene expression in whole human embryos across several weeks of early development offer insights into the molecular programs that drive organogenesis.

go.nature.com

A new way to understand and predict gene splicing

The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.

news.mit.edu

biorxiv.org

Nitric oxide drives proteomic diversity through alternative splicing

Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.

dlvr.it

Stem cells as an essential mediator of the exercise–tumorigenesis link

Nature Reviews Cancer, Published online: 14 May 2026; doi:10.1038/s41568-026-00933-zAerobic exercise influences physiology and generally reduces cancer risk, yet the mechanisms connecting these effects remain incompletely understood. In this Perspective, Zhuang and colleagues outline a model in which exercise-induced physiological adaptation regulates adult stem cell behaviour in ways that limit transformation and tumour initiation.

dlvr.it

Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

nature.com