@xueyuguo.bsky.social
We can finally reveal that we will present and discuss new data revealing the impact of dyslexia and other SpLDs at the RSE Curious Festival. Come along to be part of the conversation rse.org.uk/event/dyslex...
Dyslexia as a mental health story
Exploring the relationship between dyslexia, dyscalculia and mental health.
rse.org.uk
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
nature.com
The contrastive learning framework DrugCLIP enables screening of ~10,000 human proteins against 500 million compounds in under 24 hours, achieving experimentally validated hit rate up to 17.5%. #NBThighlight www.science.org/doi/10.1126/...
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
science.org
AlphaFold database now includes 1.7 million 'homodimers' - comprising two interacting strands of the same molecule go.nature.com/4sjP69b
AlphaFold hits ‘next level’: the AI tool now includes protein pairing
Nature - The database of 200 million protein-structure predictions now includes homodimers, adding new biological relevance.
go.nature.com
We cannot wait to host @kuludwig.bsky.social in St Andrews and hear all about this exciting study. Come along on Wednesday 11th March, 1pm, BMS building @uniofstandrews.bsky.social
Kerstin Ludwig@kuludwig.bsky.social · 7mo ago🖨️ Hot off the press 🍾 : I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version: rdcu.be/e4Lg8
For free access to a version of the article that's nearly the same as the publication version, see the preprint: www.medrxiv.org/content/10.1...
Estimating ascending aortic diameter from the electrocardiogram
In an analysis of 69,173 UK Biobank participants, we paired MRI-based measurements of the ascending aortic diameter with ECG signal. We trained a 1D convolutional neural network (ECGAI-TAA) to consume...
medrxiv.org
The brain and vagus nerve play a key role in exacerbating tissue damage after a heart attack, but there are ways to block it go.nature.com/3ZG17Jr
Damage from a heart attack comes from brain signals, mouse study suggests
Nature - The brain and vagus nerve play a key role in exacerbating tissue damage after a heart attack, but there are ways to block it.
go.nature.com
Discovery of an entirely new potential approach to atherosclerotic heart disease: targeted immunotherapy! Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org www.science.org/doi/10.1126/...
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Vascular smooth muscle cell (VSMC) diversification drives atherosclerotic coronary artery disease (CAD). Mechanisms governing these cell state transitions remain unclear. We applied multiomic single-c...
science.org
This, outlined by @stephenturner.us, is quite interesting. The first use example (identify your gaps in the literture timeline for a topic) is compelling—perhaps more so for incredibly niche areas where publications are all over the place.
Zotero + Consensus AI
Sync your Zotero library to Consensus AI to ask questions about papers you've saved, and find and fill in gaps in your collections.
blog.stephenturner.us
Preprint: Genome-Scale Perturb-Seq in Primary Human CD4+ T Cells Maps Context-Specific Regulators of T Cell Programs and Human Immune Traits papers.ssrn.com/sol3/papers.... @marsonlab.bsky.social @jkpritch.bsky.social
AstraKit: Customizable, reproducible workflows for biomedical research and precision medicine www.biorxiv.org/content/10.6... 🧬💻🧪 gitlab.gwdg.de/MedBioinf/mt...
Behavioural and psychosocial interventions can effectively reduce the risk of cardiovascular disease. A Perspective in Nature Reviews Psychology identifies the elements and actions needed for a broad implementation of these interventions in standard cardiovascular care. go.nature.com/45tN6lC 🔒
A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
FYI: New online! Is enhancer-driven gene regulation all wrapped up?
Is enhancer-driven gene regulation all wrapped up?
Nature Reviews Genetics, Published online: 16 September 2025; doi:10.1038/s41576-025-00880-9In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
nature.com
