Yutong Zhang
@zyt0329.bsky.social
Postdoc researcher A chemistry student trying to understand Biology
We lost a giant of #glycotime, John Hanover @niddk 😢 . His pioneering work on O-GlcNAcylation as a modulator of glucose metabolism transformed our understanding of glycosylation as a signaling PTM. In this 2023 podcast he shares his passion for the field. irp.nih.gov/podcast/2023...
Dr. John Hanover — The Bittersweet Study of Glycobiology | NIH Intramural Research Program
irp.nih.gov
EMBL and University of Washington researchers have developed NovoTags – AI-designed protein tags – that in future could help researchers combine fluorescence microscopy and cryo-ET, helping identify individual proteins inside cells. @steffenklein.bsky.social More info 👉 www.embl.org/news/science...
Chemical biology royalty here at Stanford for the annual @onoinitiative.bsky.social symposium, here are just a few of legends:
New online: A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling
A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling
Nature Structural & Molecular Biology, Published online: 15 June 2026; doi:10.1038/s41594-026-01821-8Veit et al. present a fluorescence microscopy platform to measure protein scramblase-mediated lipid flipflop across membranes by imaging single vesicles containing fluorescent lipid probes to quantify precise transport rates.
dlvr.it
Nature research paper: Mitochondria directly interact with the nuclear pore complex go.nature.com/4xoZS0M
Mitochondria directly interact with the nuclear pore complex - Nature
Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.
go.nature.com
Researchers pioneer method to rapidly design proteins Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.
Researchers pioneer method to rapidly design proteins
Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.
www6.slac.stanford.edu
I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.
Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 4mo ago🌟From the desk of @seanjmorrison.bsky.social: It's a great day for CRI, which now has 2 @nasonline.org members. Congratulations to @rjdlab.bsky.social and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery 🧪 cri.utsw.edu/deberardinis...
What's better than one #HHMIInvestigator being elected to the @nasonline.org? Ten! Meet the newest members, recognized by their peers for distinguished, ongoing contributions to original research: bit.ly/4cCxRuv.
The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info: mrclmb.ac.uk/careers-and-... Please circulate this post to anyone who might be interested!
great!
Stephan Hacker@stephanhacker2.bsky.social · 4mo agoI am very excited that we will again have three slots for Flash Talks by #PhDs and #Postdocs at the 6th Virtual @chembiotalks.bsky.social! If you are interested in applying, enter our abstract challenge: fd24.formdesk.com/universiteit... #ChemBio #ChemSky #Presentation #Networking #Award
ICYMI: New Online! Technologies to measure and modulate protein subcellular localization
Technologies to measure and modulate protein subcellular localization
Nature Reviews Molecular Cell Biology, Published online: 19 March 2026; doi:10.1038/s41580-026-00957-1Subcellular localization is important for protein function. This Review discusses advances in spatial subcellular proteomics, assesses the strengths and weaknesses of technologies that measure and control protein localization, and considers their potential uses in cell biology and medicine.
dlvr.it
Join Matthew Vander Heiden (MIT), Sarah-Maria Fendt (VIB), Ralph J. DeBerardinis (UTSW), and me (Deputy Editor @science.org) online Wed March 18 to hear about the influence of metabolism on cancer progression. Free registration below. lifesciences.westlake.edu.cn/media/events...
Rethinking Cancer Metabolism - Westlake x Science\/AAAS Joint Online Symposium #01 (2026)
Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...
lifesciences.westlake.edu.cn
Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases www.nature.com/articles/s41...
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology
Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...
nature.com
Nature Cell Biology@natcellbio.nature.com · 6mo ago☕ @zyt0329.bsky.social et al develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH. 👉https://rdcu.be/e3TPL bit.ly/4auh4aD
Excellent work！
Edoardo Gianni@edogia.bsky.social · 6mo agoHow could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...
Thank you for highlighting our work with very visionary perspectives! @mstagi.bsky.social @natcellbio.nature.com Decoding the proton veil around lysosomes www.nature.com/articles/s41...
Decoding the proton veil around lysosomes - Nature Cell Biology
A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...
nature.com
www.nature.com/articles/s41...
DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
nature.com
📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026! 📅 8 - 11th September 2026 📍 EMBL Heidelberg, Germany 🔗 www.embl.org/about/i... Submit your abstract by 2nd June 2026 to a part of the event! EMBO #ChemicalBiology
Beyond thrilled to share my PhD work out today in @natcellbio.nature.com , uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳 Great thanks to my advisors and excellent peers for helping me！ www.nature.com/articles/s41...
DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
nature.com
Congrats to my advisor Weihong and team！ doi.org/10.1126/scie...
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling
Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell pe...
doi.org
Cheers！Finally get my doctoral diploma and become Dr.Zhang🥳🥳 Look forward！
First time to make an offline flash talk to present my PhD work🤩🤓 Really good opportunity😍
Glad to share my work and to receive first prize award of poster ！🤩🤩🤩
These intriguing materials - the world's most porous sponges - won today's Nobel Prize in Chemistry go.nature.com/3VVjXug
World’s most porous sponges: intricate carbon-trapping powders hit the market
Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.
go.nature.com
