Álvaro López Codina
@alcodina.bsky.social
Predoctoral Research Assistant at the Llorca Lab @cniostopcancer.bsky.social working on mTORC1 signaling and cryo-EM ❄️🔬. Intrigued by the structural mechanisms of protein assemblies involved in endomembrane signaling and trafficking 🧪.
Evolutionary analysis of PINK1 reveals key roles of the N- and C-terminal extensions and TOM20 in folding its kinase domain https://www.biorxiv.org/content/10.64898/2026.09.05.749644v1
August's software push includes - AlphaFold3, AlphaPulldown, AmberTools, CCP4, Chromap, COOT, cryoDRGN, DIALS, Foldtree, ICM Browser, NMRFx-Anaylst, OpenFold3, Open Force Field Toolkit, OpenMM, pyCoAn, pytom-match-pick, RDKit, Scipion, Schrödinger, Warp, and XDS. More here: buff.ly/wN9LYyJ #SBGrid
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
sbgrid.org
#OPENACCESS: Recovering membrane interaction kinetics of single molecules from 3D tracking data. Erik Lundin, Ivan L. Volkov, Magnus Johansson. buff.ly/FW1q5iU
https://www.cell.com/biophysj/fulltext/S0006-3495(26)00540-0
cell.com
Jessica Sheu-Gruttadauria et al. show that the material properties of the #nucleolus are shaped by the assembly state of ribosomal precursors, which tune nucleolar dynamics and morphology through their interactions with the nucleolar scaffolding protein NPM1. rupress.org/jcb/article/... #Biophysics
Structural basis of a SWI/SNF-associated transcription pre-initiation complex pubmed.ncbi.nlm.nih.gov/42710485/ #cryoEM
Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features!
Vignogna (@rvig.bsky.social) and Fromme (@fromme-lab.bsky.social) identify GAP activity in several DENN domain proteins, revealing unexpected functional diversity within this protein family. rupress.org/jcb/article/... #GolgiTime #GTPases #Migration #Biochemistry #StructuralBiology #Golgi
The native structure of the Trichonympha centriole cartwheel reveals a zigzag stacking pattern pubmed.ncbi.nlm.nih.gov/42709820/ #cryoEM
New paper from the Capelson Lab in collaboration with the @ranganlab.bsky.social where they found that Nup93-2 only partially overlaps with mature NPCs. This off-pore Nup pool helps silence Polycomb domains. 🤩https://www.biorxiv.org/content/10.64898/2026.08.28.747911v1
Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling
Nuclear pore complexes (NPCs) are nuclear envelope (NE)-embedded protein assemblies that mediate nucleocytoplasmic exchange and interact with the genome, including binding of an NPC component Nup93 to...
biorxiv.org
Online Now: TRiC/CCT chaperonin governs RNA polymerase II activity in the nucleus to support RNA homeostasis Online now:
TRiC/CCT chaperonin governs RNA polymerase II activity in the nucleus to support RNA homeostasis
The TRiC/CCT chaperonin governs the enzymatic activity of RNA polymerase II (RNAPII), as changes in their interaction alter the global production of RNAPII-associated RNA. The balance between TRiC/CCT binding classic protein substrates and RNAPII contributes to RNA homeostasis.
dlvr.it
Perspective: Harriet Lo, Robert Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...
Susanne Steigleder, Julian Nüchel @jnuechel.bsky.social, Marius Lemberg @marius-lemberg.bsky.social and colleagues identify a Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65. journals.biologists.com/jcs/article/...
ICYMI: New online: Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome
Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome
Nature Structural & Molecular Biology, Published online: 08 September 2026; doi:10.1038/s41594-026-01878-5Cui, Sheng and colleagues present cryo-EM structures of human NLRP6 monomer in the ATP/NBD-bound and ATP/NBD-unbound conformations, revealing the detailed mechanisms of how ATP acts as an endogenous inhibitor of the NLRP6 inflammasome.
dlvr.it
PISD acts as a switch between #lipophagy and fatty acid transfer to #mitochondria. From Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao and colleagues: rupress.org/jcb/article/... 📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti... #EMBOLipidCode
Endosomal membrane state governs trafficking and cell migration under TFEB control www.biorxiv.org/content/10.6...
Endosomal membrane state governs trafficking and cell migration under TFEB control
Transcription Factor EB (TFEB) regulates the biogenesis of lysosomes, which are acidic organelles of the endosomal network. While its role in cellular clearance is well established, the pleiotropic fu...
biorxiv.org
www.pnas.org/doi/10.1073/... Myosin II–independent contraction of actin filaments in membrane nanotubes
www.pnas.org/doi/10.1073/... Coordinated regulation of diverse F-actin organizations orchestrates F-actin pulses in the actomyosin network
www.cell.com/iscience/ful... Coordinated action of RAB11, Sec4, myosin V, and the exocyst governs Aspergillus nidulans tip growth
Coordinated action of RAB11, Sec4, myosin V, and the exocyst governs Aspergillus nidulans tip growth
Biological morphology; Molecular biology; Molecular interaction
cell.com
A novel mechanism of ubiquitin-charging a bivalent E2:RING E3 complex https://www.biorxiv.org/content/10.64898/2026.09.04.749512v1
🎉 Our DENN GAP paper is now out in JCB! Some exciting new results were added since the preprint, including the discovery that yeast and human AVL9 differ in substrate specificity. rupress.org/jcb/article/...
Avl9 defines a family of DENN domain GTPase-activating proteins
Using computational protein–protein interaction screens, Vignogna and Fromme identify Avl9 as a GTPase-activating protein for Arf-family GTPases. They demo
rupress.org
Structural insights into actin severing and capping by gelsolin pubmed.ncbi.nlm.nih.gov/42710486/ #cryoEM
Congratulations, Julia Mahamid! The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology. Learn more: www.embl.org/news/awards-...
Leucine Regulates Neuronal Health During Nutrient Deprivation in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.04.748567v1
Proteins are always moving. They wiggle. They jiggle. They interact with their surroundings. That movement drives their function. Yet the motion stays mostly invisible. We cannot understand protein function, engineer it, or correct it until we can see the motion and predict it. prismscience.org
Prism | Revealing the Dynamics of Life
Dynamic structural data, models, and language to become standard across the field. At scale, this is how we predict conformational ensembles across all of biology.
prismscience.org
Spotlight: Geert Kops previews work from Tran, @dumontlabucsf.bsky.social et al. (rupress.org/jcb/article/...), which uses super resolution live imaging to show that #condensin is required for local structural organization and microtubule attachment of #kinetochores. rupress.org/jcb/article/...
To fuse, or not to fuse: Closing in on the nuclear envelope fusion machinery
To fuse, or not to fuse: Closing in on the nuclear envelope fusion machinery
Nuclear pore complex assembly is an intricate process occurring in the double bilayer of the nuclear envelope. In this issue of Molecular Cell, Fischer et al. Maslennikova et al. and Wang et al. integrate genetic analysis across model organisms with functional studies and molecular simulations to better understand a key step—membrane fusion.
dlvr.it
From wireframes to immersive reality: a historical perspective on molecular visualization software pubmed.ncbi.nlm.nih.gov/42704848/ #cryoEM
Cryo-EM reveals the central steps of mitochondrial complex III assembly and the cooperative assembly of supercomplex CIII2CIV www.biorxiv.org/content/10.64898/2026.09.07.749710v1 #cryoEM
The Gp78 ubiquitin E3 ligase drives mitophagy by regulating omegasome formation https://www.biorxiv.org/content/10.64898/2026.09.04.749530v1