ICYMI: Beyond the quick win: rebuilding the foundations of cancer immunotherapy

Beyond the quick win: rebuilding the foundations of cancer immunotherapy

Nature Reviews Immunology, Published online: 25 August 2026; doi:10.1038/s41577-026-01352-9Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.

dlvr.it

Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function @cellcellpress.bsky.social www.cell.com/cell/fulltex... @stanforduniversity.bsky.social #Roth #Satpathy

Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P

Nature Reviews Immunology@natrevimmunol.nature.com · 2mo ago

Why adaptive immunity?

Pre-print alert 📰 🚨I’m very grateful and excited to share our new study : "Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion". doi: doi.org/10.64898/202... lnkd.in/eJwMTUEt

🔬 We’re hiring again! Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬 Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in 🇩🇰 Klaus Eyer’s lab, Aarhus 🇳🇴 Victor Greiff’s lab, Oslo ⏳ Deadline: May 10 👉 euraxess.ec.europa.eu/jobs/403235

Open Call for 1 PhD Position at Università Vita-Salute San Raffaele in the frame of the MSCA Doctoral Network

Multiple sclerosis (MS), is an autoimmune disease of the central nervous system (CNS), characterized by demyelination and neuronal loss, along with immune cell brain infiltration and inflammation.

euraxess.ec.europa.eu

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

cell.com

Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.

Emma Slack@mucosalimmunology.bsky.social · 11mo ago

1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!

1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!

Emma Slack@mucosalimmunology.bsky.social · 12mo ago

We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬 join.com/companies/im...

We are hiring! 🧫 🧬 🚀 Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland. See here for details (Deadline: 7th November 2025): join.com/companies/im...

Botnar Institute of Immune Engineering - BIIE (Zürich): Doctoral studentships, Molecular Mucosal Immunology Group

Botnar Institute of Immune Engineering - BIIE has a job opening for Doctoral studentships, Molecular Mucosal Immunology Group in Zürich (published: 29.10.2025). Apply now or check the other available...

join.com

Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens! SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)

Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Ultra-high-scale cytometry-based cellular interaction mapping - Nature Methods

Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

nature.com

Nature Methods@natmethods.nature.com · last yr.

For a quick summary, read the Research Briefing here: www.nature.com/articles/s41...

Our new review article led by Jordan Kramer: Platforms for studying cell–cell recognition by immune cells onlinelibrary.wiley.com/doi/10.1111/...

As promised, a 'skeet' -orial on our paper published last week !

Cell - a Cell Press journal@cp-cell.bsky.social · 2y ago

Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below! www.science.org/doi/10.1126/...

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate

TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

science.org

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/

1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!

Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!

Emma Slack@mucosalimmunology.bsky.social · 2y ago

Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal: www.jobs.ethz.ch/job/view/JOP... Closing date: 24th Feburary 🧪🧫🔬

Our new work! The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination www.biorxiv.org/content/10.1...

Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection #Tpex www.nature.com/articles/s41...

Nature [Unofficial]@nature.com.web.brid.gy · 2y ago

Our work led by Anna Huhn is now published! The molecular reach of antibodies crucially underpins their viral neutralisation capacity lnkd.in/epe8YZPm Thank you to the reviewers for constructive feedback!

Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything. The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n) doi.org/10.1242/dev....

A timed epigenetic switch balances T and ILC lineage proportions in the thymus

Highlighted Article: Delayed activation of the T-cell lineage commitment regulator Bcl11b in mouse thymic progenitors due to distal enhancer deletion reduces T-cell output and increases Zbtb16-driven ...

doi.org

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

Prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement www.nature.com/articles/s41... @koledegolier.bsky.social www.nature.com/articles/s41...

Biologist, stop putting UMAP plots in papers! Blogpost here: simplystatistics.org/posts/2024-1...

'The TME of Long Term Survival cases was distinguished by coinfiltration of T cells, B cells & plasma cells, along with upregulation of the PD-1/PD-L1 pathway. Remarkably, these prognostic associations were almost entirely restricted to tumors with high-epithelial content & the C4/DIF mol. subtype'

"(...) reinforcing 41BB costimulation on the day of vaccination did not result in a substantial improvement in vaccine responses. However, reinforcing 41BB costimulation on day 4 after vaccination, when 41BB expression levels were highest, resulted in a profound improvement in CD8+ T cell responses"

🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415...