Excited for this new chapter!

Oxford Biochemistry @oxfordbiochemistry.bsky.social · 4d ago

Fantastic news that Adele Marston will join us in 2027 as Professor of Molecular and Cellular Biochemistry at the University of Oxford. 🎉 🎉 🎉 Read the full story 👇 bit.ly/marston_10_26

The Rockefeller University @rockefeller.edu · last wk.

Rockefeller's C. David Allis revolutionized our understanding of how genes are expressed. His discoveries ushered in the modern era of chromatin biology and epigenetics and laid the foundation for new approaches to treating cancer and other diseases. #125YearsofRockefeller

Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections

I really enjoyed chatting with Stefan at the recent EMBO transcription and chromatin meeting about some of my thoughts on CpG island biology!

Epigenetics Podcast@epigeneticspod.bsky.social · 3w ago

In this episode we speak with @robklose.bsky.social, Professor of Genetics at the University of Oxford, about how CpG islands help control gene expression and chromatin regulation during development. #podcast #epigenetics Listen here: activemotif.com/podcasts-rob...

brilliant

UCSC Genome Browser@genomebrowser.bsky.social · 3w ago

New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified. Explore hub: genome.ucsc.edu/s/Lo... More public hubs: genome.ucsc.edu/cgi-...

Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8

Very happy to share the first pre-print from my postdoc work with @larsplus.bsky.social (which we also presented at the excellent @isehsociety.bsky.social Annual Meeting last weekend). Here we performed a CRISPRi Perturb-seq screen targeting >500 transcriptional regulators in ex vivo mouse HSPCs.

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...

An elegant explanation for why L1 is enriched on the X chromosome!

Geoff Faulkner@faulknerlab.bsky.social · 2mo ago

Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...

Super-exciting live-imaging method of nuclear RNA!

Emilia Dimitrova@edimitrova.bsky.social · 3mo ago

Amazing new method for live-cell imaging of RNA molecules developed by Adam in the Brockdorff lab! Worth having a look at!

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

biorxiv.org

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

There is more to transcriptional readthrough than meets the eye, and it could even provide a therapeutic opportunity in cancer. Check out our new perspective, inspired by recent work from Neugebauer and Grzechnik labs! #RNABiology #RNASky #Epigenetics

Agata Stepien@agatakstepien.bsky.social · 3mo ago

Studying gene ends is becoming even more fascinating! Curious why? Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication by Podszywałow-Bartnicka and @karlaneugebauer.bsky.social @natsmb.nature.com

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

I only want to strongly emphasize that everyone must go to the @qedscience.bsky.social homepage to see their AI slop promotional ads. They are DERANGED! Two end in scientists dying, and one strongly implies bestiality. I can't get them out of my head!

QED Science@qedscience.bsky.social · 4mo ago

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications! www.nature.com/articles/s41... Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.

Guifeng Wei@guifengwei.bsky.social · last yr.

Fresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬 She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing. www.biorxiv.org/content/10.1...

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.

SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation - Nature Communications

Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in which nascent Xist transcri...

nature.com

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

Congratulations to Colin Kleanthous and Rob Klose on joining the Fellowship of the Royal Society

The two scientists have been selected for outstanding contributions to their fields

bit.ly

New online! The discovery of gene imprinting

New online! RNA design across eras: from covariance models to modern generative AI

Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy

Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c

Donate to Cycling from Exeter to the 3' end (in Oxford)!, organized by Steven West

I'll be cycling from Exeter to Oxford (about 160 miles/260 km) - hopefully … Steven West needs your support for Cycling from Exeter to the 3' end (in Oxford)!

gofund.me

Stunning work — acquisition of IDRs in SON appears to have driven the evolution of nuclear speckles, enabling selective splicing of GC-rich intron–exon units.

Tugce Aktas@aktast.bsky.social · 8mo ago

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

super cool

Phil Holliger@philholliger.bsky.social · 8mo ago

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

Yesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."

Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology

RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

nature.com

an interesting work on how RNA regulatory elements control immune systems.

The Francis Crick Institute@crick.ac.uk · 9mo ago

Researchers at the Crick, @cam.ac.uk and Sanquin Research Amsterdam have made a key discovery about how the immune system can switch from ‘on’ to ‘off’ so quickly. The findings could offer potential new avenues for treating cancer or autoimmune conditions. www.crick.ac.uk/news/2026-01...

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...