🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Cannot be more excited about the lineup for the inaugural Function of Evolving Systems GRC conference I am co-organizing with the amazing Joy Bergelson. Less than a month away: August 9 - 14, 2026. Still a few spots left! And do check out the amazing list of speakers: www.grc.org/function-of-...

New results with tree reconstruction of glioma progression. Phylodynamics applied to primary patient samples allow to define how progression is linked to changes in differentiation hierarchies. We ❤️ trees!

Masashi Nomura@masashi-nomura.bsky.social · last mo.

1/12 Excited to share that our new paper on IDH-mutant glioma (IDH-G) is now out in Nature Genetics! This work was a fantastic collaborativ effort of laboratories of @suvalab.bsky.social and @landau.bsky.social, co-lead by Ramya Raviram and Joshua S. Schiffman. www.nature.com/articles/s41...

Please join us in NH (perfect place to be in August!) for this inspiring conference organized by @petrovadmitri.bsky.social and Joy Bergelson. Very interdisciplinary, so I look forward to learning tons of new concepts. www.grc.org/function-of-...

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Interested in DNA damage and the mechanisms of mutagenesis? We are hiring post-doctoral scientists as part of the amazing CAUSE Cancer Grand Challenge team. Biochemistry, genomics and computational biology... tinyurl.com/yc5xs3wa tinyurl.com/4unu5uu9 CAUSE www.cancergrandchallenges.org/cause

A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution? Postdoc D. Cheek had the creative idea to use patient ages to try and answer this question. Read new paper out here: www.nature.com/articles/s41...

Age distinguishes selection from causation in cancer genomes - Nature Genetics

Mutations may be enriched in tumor samples because they promote carcinogenesis or because they promote clonal expansions in healthy tissue. This study mathematically disentangles these two possibiliti...

nature.com

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

Evolutionary characterization of lung cancer metastasis - Nature

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

nature.com

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Did you catch our news during #MarkSymposium? We’re accepting applications for our 2026 Emerging Leader Awards, now offering $1 million over 4 years & open to investigators worldwide! Submit your LOI by April 30: themarkfoundation.org/emerging-lea... #ResearchFunding

Emerging Leader Award | The Mark Foundation for Cancer Research

themarkfoundation.org

The conference is quickly filling up! Don't wait to sign up. We also received some funding and can offer fellowships to graduate students and postdocs. Won't cover the whole cost but will certainly make it much easier!

Dmitri Petrov@petrovadmitri.bsky.social · 6mo ago

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

📢 Postdoc position available in my lab We study mutagenesis, population genetics, and Mendelian genomics—linking the origins of mutations to their biological and disease consequences. Details about research directions: labs.utsouthwestern.edu/seplyarskiy-... Please reach out if interested.

🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇

Chen Weng@wengchen.bsky.social · 6mo ago

Can we accurately map cell family trees using mtDNA? Excited to share MitoDrift, a high-precision single-cell lineage inference tool, enabling reliable mapping of lineage history to cell phenotypes. doi.org/10.64898/202... Joint with @gaoteng.bsky.social. @bloodgenes.bsky.social @jswlab.bsky.social🧵

Please come join us - so excited for this conference!

Dmitri Petrov@petrovadmitri.bsky.social · 6mo ago

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

IICD welcomes next David Cheek from @harvard.edu on Feb. 11 at 2 PM, as part of our seminar series. Dr. Cheek will discuss causation in cancer genomes. Register: cancerdynamics.columbia.edu/events/iicd-... cc: @harvardmed.bsky.social @naxerova.bsky.social

📢 Announcing The Mark Foundation 2026 Emerging Leader Award winners! 📢 We are committing $3.75 million to 5 visionary early-career scientists poised to lead the next generation of oncology breakthroughs. We can't wait to see their impact! themarkfoundation.org/2026/01/2026...

Very nice! www.biorxiv.org/content/10.6...

Ultra-deep duplex sequencing reveals unique features of somatic evolution in the normal tissues of a family with Li-Fraumeni syndrome

Li-Fraumeni syndrome (LFS) is caused by germline pathogenic variants in TP53 which predispose carriers to early onset cancer across multiple tissues. While genomically profiling those cancers has reve...

biorxiv.org

The abstract deadline for Mutations in Time and Space 2026 closes in 3 weeks time. Sign up here: coursesandconferences.wellcomeconnectingscience.org/event/mutati... As well as thrilling science, the programme includes dinner at the beautiful King's College in Cambridge. @eventswcs.bsky.social

Happy new year/paper! A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus aacrjournals.org/cancerdiscov...

Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Kevin Monahan@kevinmonahan.bsky.social · 9mo ago

We are looking for our new Tom Smith Clinical Research Fellow in #LynchSyndrome and Early Onset ColorectalCancer with @trevorgraham.bsky.social in translational science … thanks to 40tude curing colon cancer for supporting this fellowship - get in touch! @stmarksgenomics.bsky.social @icr.ac.uk

Come to Germany and do a PhD with DKFZ. You'll be supported by an international community doing amazing science in a fantastic place. I joined the DKTK from the UK 3 months ago and couldn't be happier with how easy it has been fitting in. The quality of work here is phenomenal and you should apply!

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 9mo ago

🚀 Thinking about your next big career step in science? The Int'l PhD Program at DKFZ could be a perfect fit for you. 🌍 Work in an international environment, with 500+ doctoral researchers 🔬 Do cutting-edge cancer research Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

nature.com

The exciting next instalment of Mutations in Time and Space... Open for registration now

Wellcome Connecting Science Learning and Training@eventswcs.bsky.social · 9mo ago

Explore the origins, patterns and consequences of mutations across biological systems! #MITS26 🗓️ Conference dates: 13-15 April 2026 Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬 Check out our exciting speakers ➡️ bit.ly/4hmbnyr #Genomics

WEEKEND LISTEN This year, the Trump admin threw everything it had at the nation's oldest and richest university 3 Harvard profs tell the story of what they saw @naxerova.bsky.social @ryanenos.bsky.social & Kit Parker www.wnycstudios.org/podcasts/otm...

S2 - Episode 1: The Harvard Plan | On the Media | WNYC Studios

The Harvard Plan - our collaboration with the Boston Globe, is back! In episode one, we hear what unfolded at Harvard from Donald Trump’s inauguration to convocation 2025. Three main ...

wnycstudios.org

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. www.biorxiv.org/content/10.1...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

nature.com