When tension increases, the nucleus escapes. New paper out in @natphys.nature.com. Check out Tom's thread for a summary 👇

Tom Golde@tomgolde.bsky.social · last mo.

New paper in @natphys.nature.com! We uncovered a stress adapation mechanism where keratin intermediate filaments in stretched epithelia undergo a supracellular bundling transition that uncages the nucleus. www.nature.com/articles/s41... @ibecbarcelona.eu, @upc.edu @qmul.bsky.social

Researchers at #FlatironCCB are investigating how the collective movement of giant sperm in fruit flies gives rise to folded layers of motion. Read more about their new hypothesis: https://bit.ly/4oKB2Vx #science #biology

Mysteries of Fruit Fly Sperm Untangled by Mathematical Models

Biologists at the Flatiron Institute’s Center for Computational Biology used mathematical models to improve our understanding of sperm structure and function.

bit.ly

ERC Advanced Grant @erc.europa.eu for @mpi-cbg.de director Stephan Grill @grill-lab.bsky.social! 🎉 He receives 2.5 million euros for his project “DNA Sequence-Dependent Structure Formation in the Cell Nucleus.” Congratulations! 🥳 🥳 🥳 www.mpi-cbg.de/news-outreac...

ERC Advanced Grant for Stephan Grill

European Research Council funds research project on physical foundation for sequence-guided genome organization with 2.5 million euros

mpi-cbg.de

Scientists discover 149 new marine species off Christmas and Cocos (Keeling) Islands

New species found in Australia's most 'pristine' marine parks

Researchers have catalogued dozens of new marine species found in the depths of Australia's most remote waters. The result is a window into a rarely glimpsed world.

abc.net.au

We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...

Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

On his birthday, we're remembering our late co-founder Jim Simons — a true visionary in mathematics, investing and philanthropy. #science #math

Really happy to see my PhD first-author paper published in @nature.com! I’m very grateful to have worked with such a great team. Huge thanks to Urša Uršič, Michael Staddon, and Jan Brugués, as well as the @brugueslab.bsky.social, and the @poldresden.bsky.social and @mpi-cbg.de community!

Brugues Lab@brugueslab.bsky.social · 8mo ago

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Interested in the MBL Physiology Course and want to learn more before you apply? Join our Virtual Open House on Tues, Jan 6, 2026 | 2–3 PM ET to meet the team, hear what the course experience is like, and get your questions answered. 🔗 Register/Join: https://go.mbl.edu/r5q

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular. apply.interfolio.com/177779

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Now out from our lab in @currentbiology.bsky.social! An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization www.cell.com/current-biol...

It was a joy to co-organize this meeting. The work presented and discussed at the meeting was exceptional. The experimental methods for quantifying key aspects of germ cell development are getting better — and the time is ripe for proposing and testing mathematical modeling of these processes!

Flatiron Institute@flatironinstitute.org · 9mo ago

#FlatironCCB's recent ScoRe meeting highlighted quantitative experimental work and mathematical models for germ cell development and for early developmental stages post-fertilization. Thanks to all who joined us! #science #biology

Congrats Ben, Claude, et al! A beautiful characterization of roles of Ca++ waves and gap junction functions in tissue patterning! www.science.org/doi/10.1126/...

Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye

Optimal neural processing relies on precise tissue patterning across diverse cell types. Here, we show that spontaneous calcium waves arise among non-neuronal support cells in the developing Drosophil...

science.org

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

Q & A

Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard Univ...

cell.com

Was a pleasure to participate in ScoRe - Scientific Conference On REproduction - celebrating 150/y since the observation of sperm and egg pronuclear fusion in @flatironinstitute.org. A stellar gathering discussing all things germ cells! Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!

New Online! Signal control during tissue regeneration in adult animals

Signal control during tissue regeneration in adult animals

Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.

bit.ly

This image shows neurons being grown on a surface with tiny patterns that resemble human tissue to ‘steer’ their growth. Models like this allow us to learn more about our nervous system and conditions like motor neurone disease. Image credit: Cathleen Hagemann and @andreaserio.bsky.social

Got to love studies that were clearly conducted "for the love of the game" (“self-decapitating sea slugs”, “plants that see and use that for mimicry”, “worms that jump in the air”, aka papers you sometimes find in @currentbiology.bsky.social ) References to all of this bellow👇

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Super impressive study by the group of Stefano di Talia on the segmentation of zebrafish notochord. There might even be a SNIC ! www.biorxiv.org/content/10.1...

Tissue-wide, synchronous Erk oscillations time the segmentation of the zebrafish notochord

The generation of a periodic body plan is a fundamental property of vertebrates. While biological oscillators provide a mechanism for timing the formation of repeated structures, few examples of signa...

biorxiv.org

🧵Does the nucleus set the cell cycle clock? 🕒 In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked. 👉 doi.org/10.1016/j.cu...

Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated Connects interpretable landscape models with data www.biorxiv.org/content/10.1...

Reconstructing Waddington's Landscape from Data

The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...

biorxiv.org

Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why? We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading. bsky.app/profile/epim...

Rotation 1 introduced me to the amazing Physarum 😍💛 Amy, Zach, Ameya, @haysconun.bsky.social and Vita from @gladfelterlab.bsky.social were encouraging TA's.

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

Belated post, but I really enjoyed working as a theory buddy with the Gladfelter lab at MBL physiology. Was refreshing to work on an array of beautiful problems in fungi and slime molds. These big, syncytial cells challenge preconceptions about cell cycles, distribution of resources, and more.

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110

Just noticed a super nice preview of our paper by @ditalialab.bsky.social and Alexandra Hiestand. As always, good editorial experience with @cp-cellsystems.bsky.social www.cell.com/cell-systems...

Vascular scaling: A careful balancing act between proliferation and extrusion

How do vascular tissues grow with the rest of the developing organism postnatally? In this issue of Cell Systems, Pi et al. combine modeling with molecular biology to uncover how cell behaviors scale ...

cell.com

Yogesh Goyal@goyallab.bsky.social · last yr.

Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h www.cell.com/cell-systems...