Social unicellular amoebae create actin-rich tunneling nanotubes that physically connect cells, allowing them to share cytoplasm and organelles, and helping the cells communicate—a possible step on the road to multicellularity. In PNAS Nexus: https://ow.ly/jyv350ZvQC5

The characteristic white #skin patches of #vitiligo are caused by a lack of skin pigments – or so we thought. New #research suggests that #melanocytes merely enter a 💤 dormant state – from which they may be awakened. http://dlvr.it/TTpHsx

Out now in @science.org Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders | Science www.science.org/doi/10.1126/...

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...

science.org

New review: Yamada, Cruz Walma, and Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis, and #cancer. rupress.org/jcb/article/...

Catfish melanomas are the first example of a transmissible cancer in fish, new genetic studies reveal. https://scim.ag/4bE0fvg

Contagious fish cancer overruns New England lake

Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal

scim.ag

Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...

In April, we welcomed scientists for #EESSexDifferences 🧬 Among the 66 posters presented during the meeting, 3 were selected for poster prizes. Please join us in congratulating: -Ithai Waldhorn -Rayyan Gorashi -Alessia Karasani Learn more about their research: s.embl.org/ees26-07-poster-prizes

Learn about cilia (dis)assembly, how cargo selection is regulated and how functions vary across tissues at the EMBO Workshop "Cilia" in Stresa, Italy, 9–12 March 2027. Early bird registration by 30 Sep Abstract submission by 30 Oct https://meetings.embo.org/event/27-cilia #EMBOcilia #EMBOevents 🧪

☕Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance. 👉https://rdcu.be/fvKac www.nature.com/articles/s41...

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome - Nature Cell Biology

Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance.

nature.com

www.nature.com/articles/s41...

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes - Nature Cell Biology

Luo et al. describe a budding type of lysosome fission linked to delivery of MFF from mitochondrial-derived vesicles to lysosomes. MFF recruits DRP1 for membrane scission. This axis restores lysosome ...

nature.com

link.springer.com/article/10.1...

Vps1 drives membrane constriction and fission necessary for endosomal protein sorting - The EMBO Journal

The trafficking of cargo between endosomes and the Golgi apparatus uses both retromer-dependent and retromer-independent routes. Disruptions to these routes lead to the mis-sorting of lysosomal cargo,...

link.springer.com

17β-Estradiol limits pathological microtubule stabilization and improves cardiac function in pulmonary artery–banded rats: doi.org/10.1172/JCI2...

🗓️ La 5ᵉ édition du #TEDImabio ce sera le 10 Septembre 2026 📍Institut du Cerveau – Paris Brain Institute 🔬Venez découvrir les dernières innovations technologiques en microscopie photonique et en optique pour les sciences de la vie, présentées par nos partenaires industriels ! 👇

What determines how epithelial cells divide when shape cues disappear? Our new work shows that division follows the axis of maximal stress anisotropy. This “principal-stress rule” links mechanics, proliferation, and homeostasis. Amazing work from @luanger.bsky.social. www.biorxiv.org/content/10.6...

Another #FluorescenceFriday. When the world is going crazy, I find some peace watching at these myeloid cells (🔴) going about their day. They exist in tissue surrounded by other cells (🔵), and you can see them popping up and down, going in and out of plane as they explore their surrounding.

Registration for the 1st France VolEM Congress is open📢 Event organized around 3 main topics ⤵️ - 3D structures across scales - Complementary methods: applications in science & industry - Life in context, a 3D story 🚨Registration is free but mandatory More info 👉 frvem2026.sciencesconf.org?lang=en

🚨 #REVIEW 🚨 Wang et al. describe how extracellular vesicles & particules contribute to the systemic effects of cancer. 👇 📖

Systemic health impact of cancer-associated extracellular vesicles and particles - Nature Reviews Cancer

In this Review, Wang et al. describe how extracellular vesicles and particles contribute to the systemic effects of cancer by providing a form of intercellular communication between tumours and the host through the transfer of bioactive cargo to recipient cells. These systemic effects include immune dysregulation in pre-metastatic niches, thrombosis and cardiovascular disease, liver metabolic dysfunction, glucose metabolism disorders and cachexia, suggesting that holistic approaches to cancer treatment are necessary to simultaneously target the tumour and its multi-organ paraneoplastic effects.

dlvr.it

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum. New study from Nicala Jenkins, Roberto J. Botelho et al. @botelholabcanada.bsky.social @torontomet.bsky.social: rupress.org/jcb/article/... #Organelles #Membrane #lipid #ER_literature #phospholipids

Exciting new publications from Club Exo-endo members! 📚 Explore their latest research and insights. Do not hesitate to read and share ! @clubexo-endo.bsky.social exoendo.org/en/publis-sc...

Publications scientifiques - Club Exo Endo - Exocytose Endocytose

exoendo.org

Neuropathic pain affects millions of people and is extremely difficult to treat. doi.org/10.1172/JCI1... Here, Daniela Menichella & team report a sex-specific role of skin Langerhans cells during the development of neuropathic pain in a mouse model of painful diabetic neuropathy.

Heterogeneity of late #endosome/#lysosomes shown by multiplexed DNA-PAINT imaging. Quantitative pipeline developed by Charles Bond, Melike Lakadamyali @melikel.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...

If you are attending BaCell3D (@bacell3d.bsky.social) from 22-24 June in Basel, Switzerland, Reviews Editor @ingridtsang.bsky.social will also be there. Don't forget to chat to Ingrid about @dev-journal.bsky.social and @the-node.bsky.social.

The first European conference on sex differences featured research looking at the source of physical differences in males and females. A participant reflected on conference takeaways, including the impact on personalised healthcare. www.embl.org/news/science...

Five takeaways from the first European conference on sex differences | EMBL

At a recent EMBL conference, scientists shared research aimed at understanding the source of gender differences.

embl.org

Starting to write up the first mechanistic paper from my lab about regulation of endosomal PI(3)P. We see retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo.

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

oy!, don't forget to register to the SFBS 2026 Advance workshop in super-resolution imaging!!! Cool instructors and speakers from the @bic-bordeaux.bsky.social @iins-bordeaux.bsky.social !!! france-bioimaging.org/news-events/...

SFBS-2026 - France-BioImaging

Home Description Program Registration Abstracts Sponsors Advanced workshop application Applications for the SFBS 2026 Advanced Workshop are now open! Please note that this form is an application for s...

france-bioimaging.org

Attending #EESMechanobiology ? If so, be sure to find and chat with @djdavid.bsky.social (Daryl), one of our senior scientific editors. He'll be on site on Tuesday and Wednesday.

Daryl Jason Verzosa David@djdavid.bsky.social · 2mo ago

Enroute to #EESMechanobiology! proud to represent both @natcellbio.nature.com as senior editor and npj Biological Physics & Mechanics as advisory editor. Let's discuss your interesting work, science publishing, & more! Find me around &at the #MeetTheEditor lunch On Wed. Note, I'm only here Tues+Wed

🔬 Les rencontres 2026 du GdR Imabio, c'est dès demain et jusqu'au 12 juin à l' #ENSParis-Saclay ! 👉 Imagerie multi-échelle, imagerie en profondeur, imagerie quantitative, microscopie et intelligence artificielle... 🔗 Le programme complet : imabio-cnrs.fr/rencontre-im... #rencontresgdrimabio2026

@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

In @jcb.org, @abdourachidthiam.bsky.social and Carpentier review seipin's role in directing lipid fate, proposing it as a multinode rheostat that manages PA, ceramide, and Ca²⁺ flux at organelle contact sites to control metabolic branchpoints. rupress.org/jcb/article/... #LipidDroplets