Delighted to share that I will organize the first India | EMBO Lecture Course on “Mitochondrial Form, Function and Signalling Across Biological Scales” in Hyderabad, India, July 2027, with Naresh Sepuri, Verónica Eisner & Pooja Jadiya. #Mitochondria #EMBOmitoScales #EMBO #Science #Research

📣 📣 The Mitochondria & Chloroplasts GRC (July 26–31) is approaching fast. We are very close to our attendance target and would love to bring together the broadest possible organelle biology community. www.grc.org/mitochondria...

Andreas P.M. Weber 🌾🌱🧬@apmweber.bsky.social · 6mo ago

🧬⚡ Call for abstracts & participants | GRC 2026 ⚡🧬 Together with Vamsi Mootha, I’m chairing the 2026 Gordon Research Conference on Mitochondria & Chloroplasts (July 19 - 24, 2026). We’d love to see your application. Thread 🧵👇

We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social

Juan C. Landoni@jclandoni.bsky.social · 4mo ago

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

🚨 Registration is open! 🚨 Join us for "Mitochondria Vol. 3: Mitochondrial Plasticity in Metabolism and Signalling", a free-of-charge international conference organized by the CRC 1218! 🗓 When: 05–07 October 2026 📍 Where: MTI, UzK Cologne, Germany 👉 Register now: mitochondria-volume3.uni-koeln.de

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

1/9 🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇 www.nature.com/articles/s42...

PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis - Nature Metabolism

Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...

nature.com

Very interesting preprint linking mitochondrial dysfunction and extracellular matrix remodeling in liver disease. Have a look!

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease https://www.biorxiv.org/content/10.64898/2026.01.16.699229v1

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

nature.com

It was wonderful to organize the @gbmev.bsky.social Cellular Organelles meeting in Düsseldorf along with Andreas Reichert at University of Düsseldorf. Leading Organelles biologists from Germany attended the 2025 meeting. Thanks to the constant support from Konstanze Winklhofer and Johannes Hermann

Attention new PIs! Here is a workshop to develop as a mentor and project leader, meet your peers and exchange experience. Please repost!

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 10mo ago

Starting your own lab is exciting—but challenging. Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026. Professional coaching, peer networking & practical tips for new PIs. Apply by Nov 30, 2025. 👉 gbm-online.de/de/young-inv... Pls repost!

Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026 lnkd.in/dgsW4c3 Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann Early registration & poster abstracts until January 31, 2026

For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below: gbm-online.de/de/tagungska...

Very special feelings to announce this one... A project that started like 10 years ago is reaching the finish line, ready to shine. In a dream-team with @beckmannlab.bsky.social we solved the long-chased structure of the active membrane protein insertase SecYEG-YidC www.biorxiv.org/content/10.1...

Substrate-induced assembly and functional mechanism of the bacterial membrane protein insertase SecYEG-YidC

The universally conserved Sec translocon and the YidC/Oxa1-type insertases mediate biogenesis of alpha-helical membrane proteins, but the molecular basis of their cooperation has remained disputed over decades. A recent discovery of a multi-subunit insertase in eukaryotes has raised the question about the architecture of the putative bacterial ortholog SecYEG-YidC and its functional mechanism. Here, we combine cryogenic electron microscopy with cell-free protein synthesis in nanodiscs to visualize biogenesis of the polytopic membrane protein NuoK, the subunit K of NADH-quinone oxidoreductase, that requires both SecYEG and YidC for insertion. We demonstrate that YidC is recruited to the back of the translocon at the late stage of the substrate insertion, in resemblance to the eukaryotic system, and in vivo experiments indicate that the complex assembly is vital for the cells. The nascent chain does not utilize the lateral gate of SecYEG, but enters the lipid membrane at the SecYE-YidC interface, with YidC being the primary insertase. SecYEG-YidC complex promotes folding of the nascent helices at the interface prior their insertion, so the examined cellular pathway follows the fundamental thermodynamic principles of membrane protein folding. Our data provide the first detailed insight on the elusive insertase machinery in the physiologically relevant environment, highlight the importance of the nascent chain for its assembly, and prove the evolutionary conservation of the gate-independent insertion route. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, https://ror.org/018mejw64, Ke1879/3, 267205415 (CRC 1208) European Research Council, https://ror.org/0472cxd90, CRYOTRANSLATION

biorxiv.org

What complex are you if you have a very versatile company in close proximity? The MICOS Complex. We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.

MINDNet: Proximity interactome of the MICOS complex revealing a multifaceted network orchestrating mitochondrial biogenesis https://www.biorxiv.org/content/10.1101/2025.05.20.655052v1

What complex are you if you have a very versatile company in close proximity? The MICOS Complex. We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.

MINDNet: Proximity interactome of the MICOS complex revealing a multifaceted network orchestrating mitochondrial biogenesis https://www.biorxiv.org/content/10.1101/2025.05.20.655052v1

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis: Molecular Cell www.cell.com/molecular-ce...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis

Mitochondria are metabolic hubs that communicate with other organelles via metabolite-, lipid-, and signaling-molecule exchange facilitated by membrane contact sites (MCSs). MCSs, regulated by tetheri...

cell.com

Some days are very satisfying as mentor…The Kondadi Lab is thrilled that Rebecca Strohm has won best Poster Prize at the recent Gordon Conference: Mitochondria Metabolism and Signaling at Ventura, California. Congratulations Rebecca💐… Keep going

x.com/dhtomar/stat... It was great visiting Wake Forest School of Medicine for delivering a talk and discussing great science.

Dhanendra Tomar on X: "It was a pleasure hosting our friends and collaborators from across the pond! @AnandMito_Lab & @KondadiLab shared fascinating insights into mitochondrial architecture and dynamics @wakeforestmed #Mitochondria #RedoxBiology #Science https://t.co/n2ia2S1Agu" / X

It was a pleasure hosting our friends and collaborators from across the pond! @AnandMito_Lab & @KondadiLab shared fascinating insights into mitochondrial architecture and dynamics @wakeforestmed #Mitochondria #RedoxBiology #Science https://t.co/n2ia2S1Agu

x.com

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...

Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open. Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland! meetings.embo.org/event/25-mit...

Mitochondria in the Nervous System

The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…

meetings.embo.org

Have a look at this exciting manuscript!

David Pla Martin@dplamartin.bsky.social · last yr.

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

Today is Rare disease day! There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social! www.cell.com/current-biol...

Compositionally unique mitochondria in filopodia support cellular migration

Marlar-Pavey et al. determine that a subpopulation of compositionally unique mitochondria, METEORs, dynamically localize to filopodia. Loss of mitochondrial targeting to filopodia correlates with a re...

cell.com

www.nature.com/articles/s41...

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature

We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...

nature.com

Well done HaGe and Company 👏

HaGe Sprenger@hagesprenger.bsky.social · last yr.

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social Thanks to everyone involved! www.cell.com/cell-metabol...

One enzyme, two mechanisms: A team led by @haukehillen.bsky.social from our institute and the University Medical Center Göttingen has uncovered how the 3’ ends of tRNAs are trimmed in the nucleus and mitochondria. ⬇️ www.mpinat.mpg.de/4919943/m_2503

Congratulations Christoph, Simon and the whole team 👏

Osman Lab@osman-lab.bsky.social · last yr.

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Researchers discovered that long-term #intermittentfasting might be unsafe for teenagers, as it can disrupt the development of #insulin-producing #betacells and potentially raise the risk of #metabolicdisorders: go.tum.de/160744 @www.helmholtz-munich.de @barteltlab.bsky.social 📷L.Matta

Intermittent fasting could be unsafe for teenagers

Long-term intermittent fasting in adolescents may disrupt the development of beta cells, which are important for insulin production.

go.tum.de

www.science.org/doi/10.1126/...

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that proteins with shared functions share amino acid sequence ...

science.org