Protein synthesis is one of the most energy-intensive & highly regulated processes in biology, yet its role as a dynamic driver of cellular and organismal function remains underexplored. Join our #TCCO conference, to share research & collaborate to answer big questions in the field. bit.ly/4wkNzBU
Leo (@kurianlab.bsky.social) and I put together a Technology preview for Molecular Cell on Ribo-Tweezer, a method that enables the removal of a ribosomal protein from a fully assembled ribosome. Check the original study published by @mbarnalab.bsky.social! authors.elsevier.com/c/1nN3p_Oylr...
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Kurianlab@kurianlab.bsky.social · last mo.Ribo-Tweezer by @mbarnalab.bsky.social, a modular platform to deplete proteins from mature ribosomes . www.cell.com/molecular-ce... @jakub-zeman.bsky.social and I wrote a Preview on why this helps to turn ribosome heterogeneity into an experimentally testable paradigm www.cell.com/molecular-ce...
New Online! Plucking cellular ribosomes with Ribo-Tweezer
Plucking cellular ribosomes with Ribo-Tweezer
Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00998-6In this Tools of the Trade, Chen & Cheng (Barna lab) describe the development of Ribo-Tweezer, a method that enables the targeted degradation of individual ribosomal proteins of the cytoplasmic ribosome.
dlvr.it
We're delighted to announce a brand new meeting series, joining the Fusion community in May 2027. *Translational Control - From Cells to Organisms Conference* 📅Date: 22 - 25 May 2027 🌏Location: Durrës, Albania Sign up for updates to find out more information on the conference: bit.ly/4eGxaQG
Registration is now open for this very exciting meeting on Ribosome Heterogeneity and Translation Control @stowersinstitute.bsky.social . Come join us! There will be open slots for talks.
’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.
Interesting symposium on ribosome heterogeneity sponsored by Science: us02web.zoom.us/webinar/regi...
Welcome! You are invited to join the following webinar: 2025 Westlake Science Symposia. After registration, you will receive a confirmation email with information on how to join the webinar.
Ribosome heterogeneity is rapidly emerging as a transformative concept in molecular biology, challenging the long-standing view of the ribosome as a monolithic, generic protein factory. Accumulating d...
us02web.zoom.us
I had the privilege to meet artist Mary Griffiths. Mary got inspired by Hi-C maps and over zooms we spoke about Hi-C maps, patterns and drawings. Mary’s Hi-C inspired art has been exhibited eg the Royal Academy. We wrote this piece about this art-science collaboration pubs.aip.org/aip/bpr/arti...
Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art
Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed
pubs.aip.org
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
nature.com
First science session of #CellBio2025! 🧫🧪 Co-organized by @iaincheeseman.bsky.social and @abbybuch.bsky.social on the importance of the physiological context on studying cell biology. As a big fan of the ECM, I couldn’t agree more!
It's an amazing time to be a cell biologist, as new tech makes probing cellular processes in physiological contexts more tractable. This is the theme of a Special Interest Subgroup that @iaincheeseman.bsky.social and I are hosting at #cellbio2025. Join us on Saturday 12/5! @ascbiology.bsky.social
Ribosomal RNA (rRNA) genes are found in hundreds of copies in the human genome. Do sequence variations in these paralogs change the ribosome function? Yes! I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico: www.medrxiv.org/content/10.1... 1/8
Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯
Payam Gammage@mito-oncogene.bsky.social · 9mo agoExcited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm
First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...
Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com
PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com
findaphd.com
An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.
Kara McKinley@karalmckinley.bsky.social · 10mo agoLab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!
Congratulations to Dan Jarosz on being named the first associate dean for basic science in the Stanford School of Medicine! news.stanford.edu/stories/2025...
Dan Jarosz becomes first senior associate dean for basic science
Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.
news.stanford.edu
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the... Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Cracking the Code: Nucleic Acid Medicines Coming of Age
The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...
natureconferences.streamgo.live
Mouse studies show that depriving neuroblastoma of polyamine causes a switch in protein synthesis to suppress tumor growth and promote cell differentiation @nature.com @childrensphila.bsky.social @princetonupress.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...
Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechan...
cell.com
Dr. Davide Ruggero of UCSF has received a rare renewal of his prestigious ACS Professorship, recognizing his groundbreaking cancer research on protein synthesis. ✨ @ruggerolab.bsky.social @ucsfcancer.bsky.social urology.ucsf.edu/news/all/202...
I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction. #RNA #Ribosome
Nature Protocols@natprot.nature.com · last yr.New Article! A tripartite cell-free translation system to study mammalian translation
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social www.cell.com/cell/fulltex...
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...
cell.com
This started out as two separate projects, actually! 🤝 @mbarnalab.bsky.social has long been interested in comparing the composition of ribosomes in different parts of a cell, since localized mRNA translation is such an important aspect of gene regulation and protein homeostasis. (2/18)
Exciting new work from Barna Lab @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
science.org
The crux of rigorously characterizing #IRES: Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues www.embopress.org/doi/full/10....
