NKG2A and NKp30 expression in NK cells correlates with preserved white matter and cortical thickness and reduced negative symptoms in psychiatric disorders

Immune dysregulation contributes to the pathophysiology of schizophrenia (SZ) and bipolar disorder (BD), but specific immune alterations remain unclea…

sciencedirect.com

Optimising DNA origami assembly by reducing off-target interactions | Nature Communications

DNA origami enables the programmable self-assembly of nucleic acids into precisely defined nanostructures, yet the influence of primary base sequence on folding reliability remains incompletely understood. In particular, off-target interactions between scaffold and staple strands may introduce kinetic traps and reduce assembly yield, even when the intended Watson-Crick complementarity is preserved. Here we show that scaffold sequence strongly affects DNA origami assembly through the prevalence of off-target binding reactions implicit in the chosen base sequence. We developed a multi-objective computational framework that scores candidate scaffold sequences according to four classes of off-target interactions and selects variants predicted to minimise these effects for a given origami design. Using this approach, we identified both favourable and unfavourable scaffold regions from biological and synthetic sequences and tested them experimentally across 2D and 3D DNA origami structures.

doi.org

Automated, modular assembly of reconstituted cell-free systems from in vitro-produced components

We developed Purified components Optimized for Flexible protein expression using in vitro-produced translation factors, an automated platform that entirely decouples translational machinery production from living cells. By synthesizing and assembling components in vitro via robotic liquid handling, this modular system provides a scalable, cost-effective environment for high-throughput biofoundry workflows and the discovery of next-generation biomaterials.

dlvr.it

COVID Vaccine Linked to New Side Effect, Especially in Older Adults

The COVID vaccine was linked to a new side effect for older adults.

ca.style.yahoo.com

The Government Doesn't Want You To Read These Zines

We sold out of the first print run! Please expect a short delay for reprinting. These packets of zines are a fundraiser for the Prairieland Defendants! Each packet comes...

firestorm.coop

Bitmine Immersion Technologies Grows Its ETH Holdings to 5.62 Million Tokens

Bitmine Immersion Technologies has announced that its ETH holdings have reached 5.62 million tokens, totaling an impressive $10.4 billion with various investments.

third-news.com

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding

Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ∼40-50% of cases[1][1],[2][2]. However, current therapies fail ...

biorxiv.org

Understanding Roof Preservation and Care: Insights from Expert Matt Edwards

Discover how proper roof maintenance can safeguard your home and elevate its market value through expert advice from Matt Edwards in HelloNation's latest article.

third-news.com

TusDCB-mediated tRNA sulfur modification is required for virulence and intestinal fitness in enterohemorrhagic Escherichia coli | Infection and Immunity

Enterohemorrhagic Escherichia coli (EHEC) is a well-known foodborne pathogen that causes not only severe hemorrhagic diarrhea but also life-threatening complications such as hemolytic uremic syndrome…

journals.asm.org

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...

onlinelibrary.wiley.com

Extracellular vesicles: Whisperers of tumor immune evasion

Cancer stem cells (CSCs) shape immunosuppressive tumor microenvironments through diverse mechanisms. In this issue of Cancer Cell, Fan et al. demonstrate that CSC-derived extracellular vesicles promote regulatory T cell expansion and facilitate immune evasion. The mechanistic details reveal a therapeutic vulnerability that enhances responses to checkpoint blockade.

dlvr.it

A cross-species atlas of the dorsal vagal complex reveals neural mediators of the effects of cagrilintide on energy balance

Nature Metabolism, Published online: 08 June 2026; doi:10.1038/s42255-026-01539-3To understand which neurons respond to and mediate the action of the amylin receptor agonist cagrilintide, the authors generated a spatially resolved transcriptomics atlas of the caudal brainstem in mice, rats and macaques. Follow-up work in rats identified brainstem Calcr/Prlh neurons as mediators of the long-term effects of cagrilintide.

dlvr.it

Purine bias in bacterial genes is driven by runaway transcription

Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.

go.nature.com

A neural basis for distinguishing imagination from reality

Dijkstra et al. show that our brain distinguishes imagination from reality by monitoring how strongly the fusiform gyrus is activated. When imagined and real images produce similar activity, people ca...

cell.com

Access Now - Joint statement on AI in warfare

We, the undersigned organizations and individuals, are deeply alarmed by the rapid militarization of artificial intelligence (AI) technologies. AI systems embedded into military kill chains are accele...

accessnow.org

Fibroblasts hold the key to TLS formation

The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of ...

cell.com