Let’s celebrate women and girls in scientific research! Often underestimated, women drive research in biomedical sciences both intellectually and at the bench. Research should be a “gender-blind” endeavor, but rarely is. Stop bigotry ! Stop unconscious bias ! Go women & girls!

Happy to share the results from my PhD thesis, in which we uncovered a function for FANCD2 on maintaining fork stability upon re-replication, now out in Nat. Commun! 📖 Read the full story here:  www.nature.com/articles/s41... Thanks to everyone who supported me along the way!

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

nature.com

If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!

Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...

science.org

George Burslem@gburslem.bsky.social · 2y ago

Ever wanted to edit a protein sequence inside a living mammalian cell? Maybe to site specifically incorporate a non-canonical residue? Perhaps you’d like to do a pull down without an antibody? Or use a small molecule fluorophore to image an endogenous protein? 1/4

FANCX=FAAP100, new Fanconi Anemia gene Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life. www.jci.org/articles/vie... www.jci.org/articles/vie...

Our latest study from my postdoctoral work has just been published in Science Advances! Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social 🔗 www.science.org/doi/10.1126/...

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.

science.org

The EMBO Installation Grants support life scientists establishing laboratories in Croatia, Czechia, Estonia, Greece, Hungary, Lithuania, Luxembourg, Montenegro, Poland, Portugal and Türkiye. 🧪 The application deadline is 15 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences

Fellowships, grants and career support – Installation Grants – EMBO

Supporting group leaders who move to host countries that are part of the Installation Grant scheme

embo.org

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes. www.nature.com/articles/s41...

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...

nature.com

Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25. youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social

KSQA: Dr. Kyungjae Myung (DNA Replication Gaps)

YouTube video by KeystoneSymposia

youtu.be

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...

CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation

Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho

doi.org

Excited to share my first co-first author paper! We uncovered a conserved role for RAD51/BRCA2 in protecting abasic sites at replication forks from MRE11 cleavage. #ssDNA gaps, #DNMT1, #POLθ, #Cryo-EM of #RAD51 bound to AP sites, and much more! Check it out!

RAD51 protects abasic sites to prevent replication fork breakage

Hanthi et al. found that RAD51 recognizes and binds to abasic sites. Together with BRCA2, RAD51 prevents the accumulation of abasic site-induced replicative DNA gaps (caused by DNA methylation, oxidat...

cell.com

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature

Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

nature.com

The drama going on in here.

New Lab Preprint! We show that ATR inhibition results in hyperactivation of PARP1 at replication forks, driven by APOBEC3B, UNG2, and APE1 reaction cascade targeting unprotected single-stranded DNA at the forks. www.biorxiv.org/content/10.1...

Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...

Chromosome Segregation and Aneuploidy

Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

meetings.embo.org