The forgotten 20 million: why is the world neglecting Afghanistan’s girls and women? www.nature.com/articles/d41...

The forgotten 20 million: why is the world neglecting Afghanistan’s girls and women?

It is shameful that half the country’s population continues to be overlooked by the international community.

nature.com

Our manuscript on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1 is finally out in @genesdev.bsky.social. Big thanks again to the Min, Lazzerini Denchi and @cejkalab.bsky.social labs! @angelotaglialatela.bsky.social genesdev.cshlp.org/content/earl...

Alberto Ciccia@albertociccia.bsky.social · 8mo ago

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Endogenous molecular glue acts as a signal in human cells - akin to auxin! Metabolite glues as a means of purine sensing and chemotherapeutic response www.nature.com/articles/s41...

Metabolite glues as a means of purine sensing and chemotherapeutic response - Nature

Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve th...

nature.com

I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

Reluctant to post too much about this but I did want to share my favourite finding from the dozens of manipulated or duplicated ThermoFisher verification blots. This one has a giant square. Enjoy!

Reese Richardson@reeserichardson.bsky.social · 5mo ago

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

🎉 Now online! The Annual Review of Biophysics is now online. The most read article is "The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms" by Villalta et. arevie.ws/3R2CANN @sashiw.bsky.social @nucleosomepolice.bsky.social

Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

nature.com

🎯🎯

This NYT magazine article on longevity science, reversing aging with cellular reprogramming, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing cancer. gift link www.nytimes.com/2026/04/27/m...

Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.

Marco Jochem@marcojochem.bsky.social · 6mo ago

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

@mads100tist.bsky.social continues his takeover in this insightful webinar 🤩 Please do attend, if interested (which you are)!

Society for Developmental Biology@socdevbio.bsky.social · 7mo ago

The next the Ethel Browne Harvey Postdoc Seminar will be held Friday, April 10 at 3 pm Eastern Time with Joaquín Navajas Acedo @mads100tist.bsky.social @biozentrum.unibas.ch and Yiqun Wang @ucsandiego.bsky.social. Register today and join us. bit.ly/42xUhYh #SDBPostdocSeminar

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

Machines on Genes 2026 8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Two deadlines coming up on 8 April 2026 i. abstract submission ii. early bird submission (save €50) Four days of 🧑‍🔬🧬👩‍🔬☀️👨‍🔬🔬❄️🧪🧫 94th Harden Conference by @lapassmore.bsky.social, Dana Branzei, me with @biochemsoc.bsky.social.

Great conference, great science and great location!

Ross Chapman@rosschapmanlab.bsky.social · 6mo ago

Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!

🤖AI tools for peer-review? I want to share my experience using q.e.d. science (www.qedscience.com), a reviewing tool with high-profile endorsements. I will report results and my impressions from the use /1

q.e.d Science

Critical Thinking AI for constructive criticism and science evaluation

qedscience.com

The next the Ethel Browne Harvey Postdoc Seminar will be held Friday, April 10 at 3 pm Eastern Time with Joaquín Navajas Acedo @mads100tist.bsky.social @biozentrum.unibas.ch and Yiqun Wang @ucsandiego.bsky.social. Register today and join us. bit.ly/42xUhYh #SDBPostdocSeminar

Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

dlvr.it

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social www.nature.com/articles/s41...

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk

Markus Englund built a tool for identifying repetitive sequences in scientific datasets! Read up here: www.sciencedetective.org/scientific-d...

Scientific datasets are riddled with copy-paste errors

Initial results from scanning through Excel files belonging to 600 published scientific papers.

sciencedetective.org

Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code! There are multiple open positions! (1/3)

A study published in Nature has identified a new mechanism that controls DNA’s ability to replicate – and thereby a cell’s ability to divide. A protein, PAF15, acts as the brake, preventing the replication machinery from becoming overloaded and protecting cells from replication catastrophe. 🧪

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication - Nature

PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

go.nature.com

Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis. #AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria www.nature.com/articles/s41...

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school: www.imprs-lm.mpg.de/index.php/le... (2/3)

Tomorrow (Tue 3rd)! PLEASE NOTE THE ALTERNATIVE ZOOM LINK! 👇

Our Science paper is out! 😃 www.science.org/doi/10.1126/...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

science.org

This just in. So honored and grateful...

HHMI@hhmi-science.bsky.social · 8mo ago

We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social

Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1