Piotr Kolata
@piotrkolata.bsky.social
Postdoc at @mrclmb.bsky.social @matteoall.bsky.social group. Studying #nuclearenvelope across scales #teamtomo and team #cryoEM ❄️🔬 previously @viblifesciences.bsky.social, Rouslan Efremov group, respiratory complex I
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
Anthropic has used Claude to optimise structure prediction and design code to improve speed and memory efficiency. 2-3X speed improvements on AF3, 5X on OF3, 5X on BindCraft low memory modes to model large assemblies. All released as open source www.anthropic.com/research/cla...
How Claude is uplifting biomolecular modeling
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.
anthropic.com
So happy to see our publication about sperm #proteasomes featured in the Editorial about understanding molecular mechanism of #reproduction in @natsmb.nature.com! 🥂🎉 Thank you to everyone involved, particularly @matteoall.bsky.social @tomdendooven.bsky.social @a-dsantos.bsky.social 💙
Understanding the molecular mechanisms of reproduction
Nature Structural & Molecular Biology - Mammalian life begins with oocytes and sperm cells, but our understanding of the molecular mechanisms endowing these cells with their unique properties...
nature.com
New online: Understanding the molecular mechanisms of reproduction
Understanding the molecular mechanisms of reproduction
Nature Structural & Molecular Biology, Published online: 11 September 2026; doi:10.1038/s41594-026-01892-7Mammalian life begins with oocytes and sperm cells, but our understanding of the molecular mechanisms endowing these cells with their unique properties has lagged behind. In this Editorial, our team emphasizes the need and our wish to improve our knowledge in how these cells operate.
dlvr.it
Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...
In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia
The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...
science.org
Structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III https://www.biorxiv.org/content/10.64898/2026.09.01.748678v1
Structure and operating principles of a monkeypox virus replisome | @nature.com www.nature.com/articles/s41...
Structure and operating principles of a monkeypox virus replisome - Nature
During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 th...
nature.com
Every electron counts⚛️! Researchers have determined the structure of the protein rubredoxin at an unprecedented 0.43 Ångström resolution. The method could now allow routine quantum crystallography of biological macromolecules. 👇More about this major advancement: www.mpinat.mpg.de/5314392/rn_2...
The proteostatic environment of gametes is unique. Work just out @natsmb.nature.com from @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social is a prime example and sheds light on proteasomes in the human sperm nucleus! www.nature.com/articles/s41...
Molecular architecture and spatial organization of proteasomes in the human sperm nucleus - Nature Structural & Molecular Biology
Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...
nature.com
New online: Molecular architecture and spatial organization of proteasomes in the human sperm nucleus
Molecular architecture and spatial organization of proteasomes in the human sperm nucleus
Nature Structural & Molecular Biology, Published online: 01 September 2026; doi:10.1038/s41594-026-01870-zProteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.
dlvr.it
So happy to see our work in @natsmb.nature.com ! 💥 It was one of these two-week side projects that became the best two years of my scientific life 😅 Enjoy the summary of our story from @mrclmb.ac.uk and the publication itself! @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social
Molecular architecture and spatial organization of proteasomes in the human sperm nucleus - Nature Structural & Molecular Biology
Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...
nature.com
MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3w agoUsing advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪
Using advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪
A sad day. Ada's pioneering work on the ribosome changed how we understand one of the central machines of life. She is a remarkable example of curiosity and boldness in pursuing questions that seemed impossible. Her scientific courage and persistence has been an inspiration.
Prof. Ada Yonath, Nobel Laureate and a Model of Scientific Perseverance, Has Passed Away - Weizmann Wonder Wander - News, Features and Discoveries
From pursuing an impossible dream to uncovering one of the cell’s best-kept secrets and advancing the design of improved antibiotics
wis-wander.weizmann.ac.il
It's been a while in the making, but finally out:😂🥳 We’re excited to share our new work with H. Pavenstädt, D. Braun, M. Krahn, P. Bieling and @raunser-lab.bsky.social on INF2 and global actin remodeling! Read the story here: www.biorxiv.org/content/10.6... #Actin #Cytoskeleton #CellBiology #INF2
Kelly Nguyen, Group Leader in the LMB’s Structural Studies Division, has been awarded the 2027 Francis Crick Medal and Lecture from @royalsociety.org. Read more about @kellythd-nguyen.bsky.social’s research on telomerase here: mrclmb.ac.uk/news-events/... #LMBNews
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I www.biorxiv.org/content/10.64898/2026.08.12.744383v1 #cryoEM
Over-the-moon that our structural #cryo-em work on the #drebrin #F-actin interaction has now been published in full at #NatureCommunications. Congratulations to Weilong, Lee-Ya and the rest of the team in London and Hamburg who worked on this :) www.nature.com/articles/s41...
Structural mechanisms of drebrin-mediated F-actin network modulation - Nature Communications
Drebrin regulates crucial cellular processes through its F-actin binding and regulating functions. Here, the authors report cryo-EM structures of drebrin’s actin-binding domains complexed with F-actin...
nature.com
"Accusing him of crimes and deception wasn’t enough; the release of the diary was meant to inflict public humiliation on him". Very good article and spot on. www.theatlantic.com/ideas/2026/0...
Why MAGA Is So Obsessed With Fauci
In the aftermath of pandemics, people either try to forget them or find others to blame for them.
theatlantic.com
We finished our 2025-2026 Software Webinar season in July with a presentation from @mgflast.bsky.social on Ais, Pom, and easymode. In case you missed it, you can find the recorded version on the SBGridTV YouTube channel: buff.ly/kbQNcdx #Webinars #SBGrid #StructuralBiology
Ais, Pom, and easymode
SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont…
youtube.com
Happy to share that this beautiful work by @mudgal17.bsky.social in collaboration with the Weis lab @eth-dbiol.bsky.social, discovering a new membrane fusion mechanism in eukaryotes, is finally out in peer-reviewed form at @cp-molcell.bsky.social. www.cell.com/molecular-ce...
A conserved mechanism of membrane fusion in nuclear pore complex assembly
Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the...
cell.com
Vanni Lab at UNIFR, Switzerland@labvanni.bsky.social · last yr.Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social. How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Nature research paper: In situ structures of plant photosystem supercomplexes go.nature.com/4c4OTR5
In situ structures of plant photosystem supercomplexes - Nature
The cryo‑EM structure of the Oryza sativa photosystem II–light harvesting complex II supercomplex in its native membrane reveals the intact plant photosystem architecture, retaining physiologically relevant proteins and lipids that are otherwise lost during purification.
go.nature.com
A artificial-intelligence tool dubbed Raygun can miniaturize or supersize a natural protein without disrupting the protein’s shape or ability to function go.nature.com/4fFKvdT
This AI ‘Raygun’ can shrink and supersize proteins — opening the door to easy editing
Nature - Model modifies existing proteins using probability approach.
go.nature.com
Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae. Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...
New preprint from the lab! Led by graduate student @lainahall.bsky.social we show a new method to thin cells for cryo-EM imaging with minimal damage. www.biorxiv.org/content/10.6...
Optimized cryo-FIB milling strategy to generate thin, minimally damaged biological lamellae
Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...
biorxiv.org
Nature research paper: Structural basis of the RNA-editing cascade in trypanosome mitochondria go.nature.com/3T9HlWV
Structural basis of the RNA-editing cascade in trypanosome mitochondria - Nature
Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.
go.nature.com
