Milo Imbeni
@pyramidalmilo.bsky.social
PhD in Maastricht, microglia and microscopes
🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11
The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell. A causal spatial role for apical dendrites in the cortex www.biorxiv.org/content/10.6... by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social
So proud to see our Ashish Rajurkar’s work featured on this cover! He developed ClearDepthIAS, a scalable, non-destructive platform combining 360° infrared imaging and deep learning to quantify root system architecture in soil-grown crops. Check it out academic.oup.com/plphys/advan... #PlantSci
ClearDepthIAS enables automated high-throughput quantification of roots in soil-grown taproot crops
An automated high-throughput platform enables non-destructive measurement of root architecture in soil-grown crops, accelerating genetic discovery and crop
academic.oup.com
Plant Physiology@plantphys.bsky.social · yesterdayThe July 2026 issue of Plant Physiology from ASPB @aspbofficial and Oxford University Press is now COMPLETE! Check it out here: academic.oup.com/plphys/issue... #PlantSci
Finally out in @natneuro.nature.com! A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work! www.nature.com/articles/s41...
Creating true and false memories from forgotten information in Drosophila - Nature Neuroscience
Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...
nature.com
Thoughts on the various Trump administration proposals to revamp US science funding - and what they all have in common:
The Assault On Science Funding Continues
science.org
Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...
Ultrafast 3D imaging just got faster! Introducing: "Instant dual-view Snouty (iDV-Snouty) light-sheet microscopy" -> Double the data rate of a Snouty microscope by adding a 2nd view! Use the extra view for a variety of imaging modes! Article here: amsikking.github.io/idv-snouty_l...
It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...
Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)
Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...
forum.image.sc
posting this Classic over here in honor of the big man himself. adios bitch
Incredible timelapse of the Aurora, captured by astronaut Sophie Adenot
Shallow-water (but not deep-water) octopuses have mutations producing high-fidelity ribosomes that make a lot fewer protein aggregates of the type involved in Parkinson's, Alzheimer's, ALS & Huntington's Disease. It *may not* be a coincidence that this evolved in large-brained cephalopods.
Science Magazine@science.org · 4w agoCertain shallow-water species of octopuses carry a mutation that reduces translation errors and prevents toxic protein buildup. Learn more: https://scim.ag/44TVJ86
If you are a researcher that uses slop machines to create figures for your talk, you are embarassing yourself
I'll summarize this: Mamdani asked NYers to keep air conditioning at 78 degrees. A wave criticism hit online. A MSNBC broadcast pointed out the US Department of Energy recommends that 78 degree figure. Immediately after, the US Department of Energy deleted 6,000 web pages related to energy saving.
1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵
Edvard I Moser@edvardmoser.bsky.social · 5mo agoIs spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...
Here is yet one more example. Miller's silhouette is similar to the first Palmolive bottle, whereas he would benefit from having more padding and extension, which would create the second Palmolive bottle.
«The biases do not disappear; they get encoded into the model and then laundered into outputs that feel objective because they are numerical. Replacing one prestige filter with another that is harder to see or challenge is not progress toward equity in science; it’s the opposite. »
Ran Blekhman@blekhman.bsky.social · last mo.I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
One understressed item about various AI tools is what providers are getting out of your submissions- is your text being used for something? Who’s to say? Is it going into some model? Is a person leafing through it??? I see no reason to trust anyone on this stuff
Don't use slop. Someone's trying to make money out of you and your colleagues and your friends. Do yourself a favor and read 100% human-crated content in @prelights.bsky.social Upload preprints. Read preprints. Cite preprints. Fuck AI 🧪
Homepage - preLights
Welcome to preLights, the preprint highlights service run by the biological community and supported by The Company of Biologists. Here, a team of scientists regularly review, highlight and comment on ...
prelights.biologists.com
This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬
As a scientist, there are so many issues with this. Besides the simple technical things (e.g. no baseline or comparative models), the critical one is that there are so many dimensions of impact that any single metric is bound to be horrible and biased. This is clear already in their analysis.
HAHAHAhaha! they're making the world's biggest synthetic scum pond!!! The coating is a polyurea used inside pipes. It gels in about 3 seconds, making it non self-leveling. The texture is like an orange peel, the perfect substrate for biofilms. www.nytimes.com/2026/05/19/u...
Manager at Trump’s N.J. Golf Club Helped Plan Reflecting Pool Repairs
nytimes.com
Janelia’s decision to wind down its mouse work to focus on the Danionella fish is a “bold move” that caught some by surprise, researchers say. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/community/ex...
Exclusive: Janelia sunsets rodent work, launches transparent fish project
The Howard Hughes Medical Institute’s Janelia Research Campus is banking on whole-brain imaging in the Danionella fish to advance neuroscience, but some scientists forced to close their labs say that…
thetransmitter.org
'Storm in the Mountains', Albert Bierstadt, oil on canvas, 1870.
Rewild the reflecting pool. Make it a wetland bird sanctuary. Fill it with endangered salamanders. Foster the fermentation of whatever it is that makes swamp gas. Put up little signs welcoming fairies. Let stray senators wander in never to be seen again. Elect a bog witch. Make America Moss Again
Fantastic video on this beautiful work of Chen-Hui Chen's team!
Sasha | Kai Dao 🔬@kaidaoscience.bsky.social · 2mo ago8 hours. That’s all fish need to heal wounds 🐟⏱️ Why are they so fast compared to humans? I break down the science of rapid regeneration in a microscopy story 🔬 Watch here: youtu.be/Mt9f61adaP0 #FluorescenceFriday #Microscopy
He kept coming back, repeatedly (in the way AI often loops) to this idea of AI (specifically Claude) representing "a position without an address", and it became increasingly clear to me that there was some odd mystification happening. Of course LLM products have an address. It's a corporate address.
