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Stem Cells, Regeneration & Evolution

@stemdevevo.bsky.social

Eve GAZAVE lab @IJMonod - Stem Cells, Regeneration and Evolution using the annelid Platynereis dumerilii

992 Posts860 Follower 841 Folgt

Arnau Sebé-Pedrós @arnausebe.bsky.social · 2d ago

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Inés Fournon Berodia @inesfournon.bsky.social · yesterday

Very pleased to finally share the main story from my PhD, now published in @natcomms.nature.com ! 🎉 Using a sea anemone we discovered and characterised epithelial cell extrusion as the mechanism underlying starvation-induced cell loss. 🔗 Open-access article: www.nature.com/articles/s41...

Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone - Nature Communications

Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...

nature.com

Pawel Burkhardt @pawelburkhardt.bsky.social · 2d ago

Our Dispatch "Evolution: Ancient monoamines in a neuron-less animal" out in @currentbiology.bsky.social. Monoamine signaling and behavioral responses in placozoans suggest this system predates bilaterians. authors.elsevier.com/a/1nYJl3QW8S... @annaferraioli.bsky.social @msarscentre.bsky.social

Bardin Lab @bardinlab.bsky.social · 6d ago

A huge congratulations to Zheng and the entire Guo lab for this beautiful story! Very cool mechanism! www.nature.com/articles/s41...

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

nature.com

CNRS Biologie @cnrsbiologie.bsky.social · 5d ago

#ResultatScientifique🔎| Pourquoi les neurones sont-ils tous différents ? Des scientifiques dévoilent les mécanismes à l'origine de leur identité 🧠 ▶️ buff.ly/l676Amf ✍️ Félix Simon/Claude Desplan 📕 @NatureNeuro 🤝 @cnrs.fr @ijmonod.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social

Aux origines de l’identité des neurones

Comment le cer

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Igor Adameyko @adameykolab.bsky.social · 6d ago

The kissing of sea slugs. Reminds me of Gustav Klimt paintings. Elysia viridis, commonly known as the solar-powered sea slug or sap-sucking slug, is uniquely distinguished by its rare ability to steal plant-like cellular machinery from the algae it eats and use it to perform photosynthesis.

Agneesh Barua @agneeshbarua.bsky.social · 6d ago

How can a shared developmental programme generate the extraordinary diversity of teleost fishes? Our study suggests that the answer lies in the combination of conservation of network architecture, coupled with evolutionary flexibility in gene copy number. (1/8) doi.org/10.64898/202...

An evolvable and functionally partitioned network underlies developmental remodelling in teleosts

Comparative embryology has revealed that early animal development is based on highly conserved genetic programs. Beyond embryogenesis however, animals undergo remarkably diverse post-embryonic developmental transitions such as metamorphosis. Whether these transitions are also organised into conserved genetic programs remains largely unexplored. To identify conserved genetic programs underlying post-embryonic development, we examine metamorphic remodelling in five teleost fishes, spanning 200 million years of evolution. By integrating comparative co-expression networks, evolutionary genomics, phylogenetic modelling, and functional data in zebrafish, we uncovered a conserved post-embryonic developmental network. This conserved network comprises components involved in core cellular processes, and involved in development and physiology, both of which are under the control of thyroid hormone during metamorphosis. Despite evolutionary conservation at the coding sequence level, this network exhibits significant turnover in gene family copy number following the teleost-specific whole-genome duplication as well as lineage-specific expansions and contractions. The variation in gene copy numbers is associated with macroevolutionary variation in a number of ecological and morphological traits, including swimming performance and trophic level. Cross-species tissue expression, zebrafish single-cell transcriptomics, and zebrafish perturbation phenotypes placed the implicated genes in biological contexts relevant to these traits. Together, our results provide evidence of an ancient, functionally partitioned post-embryonic developmental network that has diversified throughout teleost evolution. The heterochronic variation in network function, changes in endocrine activity, and gene-family turnover provide potential routes through which a shared developmental architecture contributed to the evolution of phenotypic diversity in teleosts. ### Competing Interest Statement The authors have declared no competing interest. International Human Frontier Science Program Organization, LT0063/2022-L

doi.org

Vicky & The Sleight Lab @vs-marine.bsky.social · last wk.

Please share, I am hiring an evo devo postdoctoral research fellow! 📍: The Sleight Lab, University of Aberdeen, Scotland (5th oldest University in UK & English-speaking world) 📅: start after 1st December 2026 🐌: Evolution and Development (molluscs) ⌛: 3 year contract sleightlab.com/vacancies/

The EMBO Journal @embojournal.org · 2w ago

Looking for weekend reading? New review by @kei-jokura.bsky.social and @jekely.biologists.social.ap.brid.gy revisits nerve nets, their functional organization, and evolutionary implications link.springer.com/article/10.1...

eLife @elife.bsky.social · 2w ago

Are interphylum spiralian relationships resolvable?

Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.

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Development @dev-journal.bsky.social · 3w ago

In preprints – housekeeping the housekeeping genes Maxim V. C. Greenberg @maxvcg.bsky.social writes about two complementary preprints by the @grandlab.bsky.social & @schubelerlab.bsky.social labs that elucidate the mechanistic framework of essential gene expression. doi.org/10.1242/dev....

In preprints – housekeeping the housekeeping genes

The term ‘housekeeping gene’ evokes a sense of banality. These are the boring genes that hum in the background, impervious to cell state or stress. For a developmental biologist captivated by the…

doi.org

Pedro Martinez @pedromartinezserra.bsky.social · 2w ago

(Nothing new, but worth paying attention to) "Causality and Comparative Genomics/Transcriptomics" thenode.biologists.com/causality-an...

Causality and Comparative Genomics/Transcriptomics - the Node

One limitation of comparative genomics and transcriptomics in understanding the origin of evolutionary novelties is that these approaches typically

thenode.biologists.com

Developmental Biology @devbiol.bsky.social · 3w ago

#DBfeature #ICYMI Injury-induced Neuregulin-EGFR signaling from muscle mobilizes stem cells for whole-body regeneration in acoels By Brian Stevens, Riley Popp, Heather Valera, Kyle Krueger, Christian Petersen tinyurl.com/4h52at7f

Model. (A) Early wound signaling activates expression of nrg-1 in muscle near the wound site by 6 hours and subsequently in the distal blastema region from 1 to 5 days. As regeneration progresses, nrg-1 expressed from muscle signals through egfr-1, and receiving cells of this signaling could either be neoblasts (gray arrows), muscle, or other cell types. A downstream consequence of the signaling results in localization of neoblast proliferation near the blastema region, which correlates in space and time approximately with the locations of nrg-1's late expression phase. The activity of nrg-1 and egfr-1 promotes blastema outgrowth. (B) Regulatory model identifying a critical role for nrg-1 and egfr-1 functionally downstream of egr. Wounding activates immediate early expression of egr, which is responsible for transcriptional activation of nrg-1 and runt-1. nrg-1 is functionally required for regeneration and acts through egfr-1, and these factors exert critical responses downstream of egr in order to localize proliferation to wound sites and also cause blastema outgrowth. Gray lines: contributions from nrg-1 signal feedback and/or roles for pre-existing NRG-1 protein in the wound activation process (see text). (C) Phylogeny showing the conserved use of Neuregulin and/or EGFR signaling to functionally promote regeneration. Acoels are believed to be either early-branching Deuterostomes within Xenacoelomorpha or form a sister group to all Bilaterian animals (dotted lines).

Hadi Boukhatmi @muscleflylab.bsky.social · 3w ago

We have a new preprint! We identify SPARC as a key mediator of intercellular communication between the #stroma and #tumours #CancerBiology #TumourMicroenvironment #Drosophila #CellBiology #Notch #ECM #Preprint @igdrennes.bsky.social www.biorxiv.org/content/10.6...

SPARC mediates tumour–stroma intercellular communication through endosomal regulation of Delta and Notch signalling

Tumour progression relies on reciprocal communication between genetically altered cancer cells and surrounding stromal cells. While the genetic alterations that initiate tumorigenesis have been extens...

biorxiv.org

Christophe Chartreux @libreavanttout.bsky.social · 3w ago

« La disparition de l’Institut de recherche pour le développement serait une erreur stratégique pour la France » www.lemonde.fr/idees/articl...

« La disparition de l’Institut de recherche pour le développement serait une erreur stratégique pour la France »

TRIBUNE. Des directrices et des directeurs scientifiques de l’IRD demandent au gouvernement, dans une tribune au « Monde », de suspendre le projet d’absorption de leur institut par le CNRS. Cette déci...

lemonde.fr

Cells & Development @cellsdev.bsky.social · 4w ago

Heart injuries can often be fatal, yet many animals can regenerate their 🫀 without leaving any scar, while others like 👨 cannot. Part of the reason lies in how the extracellular matrix is regulated. Patra et al discussed in details how this works and what we can learn from 🐟 doi.org/10.1016/j.cd...

Fig. 1. Zebrafish heart development stages illustrated from 5 h to 5 days post-fertilization

Fig. 2. Schematic representation of the major extracellular matrix (ECM) components and their interactions during heart development.

Fig. 3. Schematic of ECM-associated congenital heart defects in zebrafish (Table 1 & 3). (A) Denotes the wild-type scenario. (B and C) Lack of med10 or med12 caused reduced cardiac jelly, impairing valve formation. Additionally, med12 deficiency causes trabeculation defects (Just et al., 2016; Segert et al., 2018). (D) npnta morphants exhibit an expanded AV canal with increased cardiac jelly in both atrium and ventricles, impaired trabeculation, and defective AVC valves (Patra et al., 2011). Orange arrows indicate the atrioventricular canal, red arrows indicate blood flow direction, hpf; hours post fertilization, dpf; days post fertilization, V; ventricle, A; atrium, OFT; outflow tract.

Fig. 4. Heart regeneration in adult zebrafish (Table 2 & 3). (A) Distinct stages of heart regeneration after cryoinjury in wild-type adult zebrafish. Injury triggers regenerative responses immediately after injury, beginning with blood clot deposition and neocoronary angiogenesis. Followed by CM proliferation and infiltration along the neocoronaries into the wound. Post-injury, during the 1st and 2nd week, collagenous scar gets deposited in the injured tissue. As the heart continues to regenerate, the fibrotic scar gradually regresses. The regeneration process is completed by 90-120 days post cryoinjury, marked with minimal or no scar remaining. (B) Disruption of hapln1-expressing epicardial cells or hapln1b mutation in zebrafish impairs cardiomyocyte proliferation and heart regeneration (J. Sun et al., 2022). (C) Fn loss-of-function zebrafish mutants exhibit poor regeneration following myocardial injury, attributed to impaired CM migration; however, CM proliferation remains unaffected (J. Wang et al., 2013). (D) In ccn2a-/- injured hearts, while angiogenesis was observed, CM proliferation and repopulation were disrupted (Mukherjee et al., 2020). dpci; days post cryoinjury, dpi; days post-injury, OFT; outflow tract, CM; cardiomyocyte.

Nicholas Bellono @nbellono.bsky.social · 4w ago

How did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...

Thibaut Brunet @thibautbrunet.bsky.social · 4w ago

Les nouvelles règles envisagées pour l'ANR sont plus qu'inquiétantes. Elles porteraient un immense coup d'arrêt à la recherche fondamentale en France, surchargeraient les jeunes chercheurs, et n'attendraient sans doute même pas leur objectif (apparent) de réduction du nombre de candidatures

Levayer Lab@levayerr.bsky.social · 4w ago

Si les nouvelles règles de l'éligibilité de l'ANR sont bien réelles, alors je ne comprends pas quelle est la logique sous jacente. Au vu de la pyramide des ages, forcer une collaboration avec chercheurs(ses) <10 ans post thèse va de facto exclure 80% des candidats.

Zenlabpasteur.bsky.social @zenlabpasteur.bsky.social · 4w ago

🚨 New pre-print alert! 🚨 Adult neural stem cell state and fate decisions are hidden within transcriptional heterogeneity. To find out how we decoded these heterogeneities to identify a molecularly encoded quiescence cycle, check out the pre-print on bioRxiv! doi: doi.org/10.64898/202...

Stem Cells, Regeneration & Evolution @stemdevevo.bsky.social · last mo.

Always a pleasure to participate to #ASCB course organized by @tajbakhshlab.bsky.social and @zenlabpasteur.bsky.social in @pasteur.fr

Tajbakhsh Lab@tajbakhshlab.bsky.social · last mo.

2nd week of #ASCB! Evolution of regeneration, Eve Gazave, hands-on Platynereis regeneration wonderfully demonstrated, with help from Zoé Velasquillo, Rémi Strehl. Francina Langa Vives and expert CIGM team had everyone try pronuclear injections + ES into blastocysts - steady hands of creation.

EnriquezLab @enriquezlab.bsky.social · last mo.

How do dozens of distinct muscles emerge from the same pool of precursor cells? Our new Science Advances paper uncovers the developmental logic that coordinates myoblast identities to build diverse muscles. 📄 www.science.org/doi/10.1126/... #DevelopmentalBiology #Drosophila #Muscle

Spatiotemporal control of myoblast identity drives muscle diversity in the Drosophila leg

This study reveals how muscle diversity arises in flies, enabling the complex movements that drive animal behavior.

science.org

BIOM @biom-banyuls.bsky.social · last mo.

🕊️ In memory of our colleague Lorenzo Bramanti We invite you to (re)discover this CNRS video highlighting his research and commitment in marine biology Au chevet du corail rouge de Méditerranée lejournal.cnrs.fr/videos/au-ch...

Au chevet du corail rouge de Méditerranée

Le chercheur et plongeur Lorenzo Bramanti est décédé le 29 juin 2026. Quelques semaines plus tôt, au large de Banyuls-sur-Mer, dans un laboratoire sous-marin unique au monde, il nous racontait comment...

lejournal.cnrs.fr

Institut Jacques Monod @ijmonod.bsky.social · last mo.

📣 The Institut Jacques Monod ( @cnrs.fr | @upcite.bsky.social ) is proud to announce the election of Dr. Nicolas Minc ( @minclab.bsky.social ) as a new member of the EMBO community! Congratulations! #EMBOMembers2026 More informations 🔗 buff.ly/2HSXoSd @embo.org @cnrs-idf-villejuif.bsky.social

EMBO@embo.org · last mo.

Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 https://www.embo.org/press-releases/seventy-one-leading-scientists-elected-to-the-embo-membership/ #EMBOMembers2026

Maria Antonietta Tosches @matosches.bsky.social · last mo.

Better late than never... an update on the recent work from the lab. First of all, the Foundation: @astridd93.bsky.social phenomenal paper on the evolution of layering in the cerebral cortex 🧵1/7 www.biorxiv.org/content/10.1...

bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · last mo.

Pax6-dependent patterning in an annelid informs the evolution of bilaterian nerve cords https://www.biorxiv.org/content/10.64898/2026.06.27.734823v1

Levayer Lab @levayerr.bsky.social · last mo.

Un pétition du collège des sociétés savantes pour mettre en avant le rôle de la recherche dans la campagne politique à venir et rappeler le sous investissement chronique en France depuis 20 ans. N'hésitez pas à faire ciculer recherche-publique-2027.fr

Recherche Publique 2027 – Appel des scientifiques pour la place de la recherche dans la société

recherche-publique-2027.fr

Marine Biological Laboratory @mblscience.bsky.social · last mo.

New research reveals surprising similarities between sea star and human ovaries, including shared cell types, genes, and signaling pathways that may date back more than 500 million years. Read the full story here: go.mbl.edu/sea-star-ovary

Thomas Dreneau @thomasdreneau.bsky.social · last mo.

Autre victime du génial Macron : outre la justice, la santé, l'éducation ou encore les transports, LA RECHERCHE. Alors que l'on ne cesse de nous parler de concurrence, de compétitivité, d'autonomie... www.lemonde.fr/sciences/art...

La recherche française déstabilisée par une crise multiforme

Affaiblissement financier et humain, montée des attaques idéologiques, émergence de l’intelligence artificielle… La communauté scientifique est confrontée à de nombreux défis, à l’image du CNRS, victi...

lemonde.fr

ASUR @agorasur.bsky.social · last mo.

La recherche française déstabilisée par une crise multiforme www.lemonde.fr/sciences/art...

La recherche française déstabilisée par une crise multiforme

lemonde.fr

PLOS Biology @plosbiology.org · 2mo ago

What are the mechanisms allowing #zebrafish to #regenerate their neurons after spinal cord injury? This study by @albertodseara.bsky.social , Catherine Becker, Thomas Becker &co shows that a protein in #microglia regulates regenerative #neurogenesis in multiple ways 🧪#AcademicSky plos.io/4xy2CcB

A graphical summary of proposed interactions of sema4ab during spinal cord regeneration. After spinal injury, microglia likely control neurogenesis directly by signaling through Sema4ab and Plxnb1a/b on ependymo-radial glial cells (ERGs), and indirectly by changing the injury site environment, which leads to lower expression of tgfb3, a positive regulator of regenerative neurogenesis, in fibroblasts. Additionally, Sema4ab controls microglia number by promoting cell proliferation.