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Alexey Veraksa

@veraksa.bsky.social

Drosophila developmental biologist. Cell signaling. Proteomics. Professor at UMass Boston.

188 Posts1417 Follower224 Folgt
Yo Akiyama@yoakiyama.bsky.social · 2w ago

Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!

Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer

Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...

cell.com

Andrew Wehrman@profwehrman.bsky.social · last mo.

Today is the 250th anniversary of Boston’s mass inoculation against smallpox on July 3, 1776. The city was effectively closed to commerce from July through September 1776. The mass immunization effort was cheered as evidence of true independence. Here's how I described it in my book:

While John Adams and fifty-five men in Philadelphia debated a resolution on independence and the final wording of the Declaration of Independence, the people of Boston declared their own independence from smallpox. The measures taken in both cities provided hope that America would not only be a republic free of a king but also a country free from disease. On July 3, 1776, a day after independence was declared in Philadelphia, the Massachusetts General Court voted to allow inoculation. Despite the dangers of infection, the people of Boston and the surrounding areas cheered the news. Ezekiel Price, a court official and insurance broker, declared “Liberty is given for to inoculate for the small-pox; many begin upon it this afternoon.” Hannah Winthrop described the scene: “Boston has given up its Fears of an invasion & is busily employd in Communicating the Infection. Straw Beds & Cribs are daily Carted into the Town.” She wrote that “Men Women & children eagerly crowding to inoculate is I think as modish as running away from the Troops of a barbarous George was the last year.” Dr. James Warren wrote to John Adams that the “rage for inoculation” had “whirled me into its vortex.…” Warren and his wife Mercy Otis joined Abigail Adams and her four children who had been invited to be inoculated at Abigail’s uncle’s house in Boston along with Abigail’s sisters Elizabeth Cranch and Mary Shaw and their families. Even though Boston was teeming with the sick, the prospect that the city could conquer smallpox made it "a scene delightful indeed." Cotton Tufts was satisfied that he could now "take my leave of Earth, satisfied that the Day of American Redemption was at Hand."
James Briscoe@jamesbriscoe.bsky.social · 2mo ago

As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

doi.org

elizabethginexi.bsky.social@elizabethginexi.bsky.social · 2mo ago

Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...

What We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB 2026-10817)

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

elizabethginexi.substack.com

@turrigiano.bsky.social · 2mo ago

Amazing job opportunity at Brandeis - we are looking for a new manager of our Light Microscopy Facility! Cool instruments, a great community to work with, lots of opportunities for growth - please circulate! brandeis.wd5.myworkdayjobs.com/en-US/Jobs/j...

Light Microscopy Facility Manager

The main purpose of this job is to bring cutting-edge light microscopy research approaches to Brandeis researchers and oversee the day-to-day operations of the Brandeis light microscopy facility. The ...

brandeis.wd5.myworkdayjobs.com

Carl T. Bergstrom@carlbergstrom.com · 3mo ago

“Units of the NIH are privately directing grantees to request permission in advance for any co-authorship with a scholar affiliated with a foreign institution, even if all the work was done in the United States.” Grantees also told to remove papers with foreign authors from progress reports.

U.S. researchers face new restrictions on publishing with foreign collaborators

NIH, NASA grantees are confused and concerned amid agencies’ piecemeal communication

science.org

Alexey Veraksa@veraksa.bsky.social · 3mo ago

If you thought Notch was always a receptor, think again! In this paper, Notch was found to function as a _ligand_ for Draper, a phagocytic receptor. #Drosophila www.nature.com/articles/s41...

Notch is a ligand of Draper mediating spermatogonia cell death - Nature Communications

Here they show that, in Drosophila testes, Notch functions as a ligand to activate Draper-dependent signalling in neighboring phagocytes and eliminate germline progenitors, revealing Reverse Notch sig...

nature.com

Stefan Luschnig@luschnig.bsky.social · 4mo ago

We´re hiring a #PhD student - if you´re interested in combining genetics, cell biology and state-of-the-art imaging to study #epithelial tissue dynamics in #Drosophila, apply to the CiM-IMPRS PhD program by May 1st (see below) Please RT @uni-muenster.de @sfb1348.bsky.social

SFB 1348@sfb1348.bsky.social · 4mo ago

Deadline approaching! The CiM-IMPRS #PhD program in #Münster is recruiting: 16 #PhD positions in Life & Natural Sciences. Great chance to do cutting-edge research in a vivid international environment—apply by May 1st: www.uni-muenster.de/CiM-IMPRS/ap... @uni-muenster.de @mpi-muenster.bsky.social

The Guardian@theguardian.com · 3mo ago

How to find a career you love – for gen Z and everyone else: ‘You don’t want your life’s compass to be dread’

How to find a career you love – for gen Z and everyone else: ‘You don’t want your life’s compass to be dread’

In her new book, New York Times investigative journalist Jodi Kantor has set her mind to helping young people find their life’s work. What should they, or anyone else who feels lost and overwhelmed right now, do to get started?

theguardian.com

@canaztekin.bsky.social · 4mo ago

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

science.org