✍️ The @romet-jegou-lab.bsky.social published a new article 📖 @pnas.org 📃 Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end 🔗 www.pnas.org/doi/10.1073/...

An excitable #Rho #GTPase signaling network generates dynamic subcellular contraction patterns. From Melanie Graessl, Johannes Koch, Leif Dehmelt, Perihan Nalbant and colleagues: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Legendary myosin researcher Jim Sellers retires after many years of making significant contributions to the field and being an unfailingly generous to colleagues - alway sharing materials, insights and wisdom. A symposium honoring Jim will be held in Sept. www.nhlbi.nih.gov/events/2026/...

Scientific Symposium Honoring Dr. James R. Sellers

Retirement symposium honoring Dr. James R. Sellers’ contributions to myosin studies. Leading scientists in the field will be present.

nhlbi.nih.gov

@vdeneke.bsky.social and @ditalialab.bsky.social review how the spatiotemporal coordination of cellular functions across large distances is controlled by chemical waves. rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

An intrinsic cytoskeletal oscillator establishes neuronal polarity. Tien-chen Lin et al. Nature (2026). DOI: doi.org/10.1038/s415...

An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

doi.org

An evolutionarily conserved, short linear actin filament-binding motif (SFM), present in >100 proteins. Great collaboration with the Windhorst and Marlovits labs. Happy to have contributed, by using macrophage podosomes as a readout. Publication in Nat Cell Biol: www.nature.com/articles/s41...

What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

Starting to write up the first mechanistic paper from my lab about regulation of endosomal PI(3)P. We see retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo.

💥 🚀 New preprint! 🎉🥳 How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪 🧵👇 (1/17)

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

1/ Our new preprint is out today.🎉 It started from a surprising control experiment while studying how talin binds vinculin. We were using the widely adopted A50I vinculin mutant to disrupt talin binding — but unexpectedly, it still bound talin. www.biorxiv.org/content/10.6...

FANTASTIC work from @myosincity.bsky.social and @pwoakes.bsky.social on smooth muscle myosin II filament dynamics! Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility www.biorxiv.org/content/10.1...

Happy #FluorescenceFriday! Just some random data I collected from a while back, actin and myosin in a U2OS cell imaged on our lattice light sheet microscope.

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods

A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

nature.com

How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...

is there a direct crosstalk between actin and vimentin intermediate filaments? Our work shows that vimentin promotes actin assembly by stabilizing ATP-subunits at the barbed end. Fantastic work done by @lilianpaty.bsky.social with @romet-jegou-lab.bsky.social www.biorxiv.org/content/10.1...

Presenting a talk the ASCB @ascbiology.bsky.social #CellBio2025 meant a lot to me, a new guy in the field. Thanks to everyone whom came for the session, and special thanks to the ones whom dropped me kind encouragements before my talk! 😊

Jerry C@xianglejerry.bsky.social · 8mo ago

Hey everyone and fellow #actin people! Here's a preview video for my upcoming talk at #cellbio2025 @ascbiology.bsky.social next Wednesday at 10am! Because it's gonna happen on the last day, so I promise to be a little funny, and I might even throw in a song and dance! And some nice data too.

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Hey everyone and fellow #actin people! Here's a preview video for my upcoming talk at #cellbio2025 @ascbiology.bsky.social next Wednesday at 10am! Because it's gonna happen on the last day, so I promise to be a little funny, and I might even throw in a song and dance! And some nice data too.

Realized this morning that my submission got selected for Yale's Beauty in Science 2025 exhibition! Seeing the live-assembly of filopodia projections by formin mDia3 in mast cells got me really stoked back then! #FluorescenceFriday

🧵5/6 — The Big Picture EndoNB works on endogenous proteins. No rare antibodies. No overexpression. It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied. We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.

🧵1/6 — Preprint Alert! I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪 www.biorxiv.org/content/10.1...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

science.org

We show that under low ahesion conditions Tensin 1 forms endogenous condensates to store inactive adhesion components. These can be released upon stress-mediated Tensin 1 phosphorylation to regulate adhesion dynamics.

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

biorxiv.org

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics! Check out the preprint here: www.biorxiv.org/content/10.1... @johannaivaska.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

biorxiv.org

Unlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/... @lblanchoin.bsky.social @manuelthery.bsky.social @gelinmatthieu.bsky.social

Progress on the quest for a red mStayGold! Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...