🔬 #JobAlert Interested in doing a PhD with us in #SyntheticBiology on the Reconstitution of Oscillatory Microtubule-Motor Systems? Check shorturl.at/wis5P (note the eligibility criteria) or/and get in touch with us shorturl.at/WmgOD. Deadline: 31 July 2026 #WeAreHiring #AcademicJobs #ScienceJobs

🚨 I am very happy to share the first preprint from our lab! www.biorxiv.org/content/10.6...

SPACA9 Acts as a Molecular Staple Modulating Microtubule Dynamic Instability

Motile cilia rely on highly stable axonemal microtubules reinforced by microtubule inner proteins (MIPs) that form a network within their lumen, yet the functions of individual MIPs remain poorly unde...

biorxiv.org

Is there a size limit for cells ? How can cells replicate inside the architecture of their environment? Why do cells self-destroy ? This 15-minute movie vimeo.com/1173229237 shows our 2026 edition of the Living Architectures project at the @museeorsay.bsky.social

Interactions between single actin and vimentin filaments https://www.biorxiv.org/content/10.64898/2026.06.11.731581v1

We found the missing piece: the front and back also activate each other at a distance via two distinct mechanochemical pathways acting via the membrane and the cytoskeleton.

Microtubule comets in human iPSCs to kick off my first week of grad school! ☄️💫

🏆 GRAND PRIZE WINNER 🏆 Congratulations to Smilla-Maria Koy (BSc Student, Mick Lab, Saarland University, Germany) for winning our Image Competition! 🔬 "IMCD3 Spheroid with Cilia" captures primary cilia emerging into the lumen to show cell polarity. #FluorescenceFriday #Cilia #ConfocalMicroscopy

Supplementary. Fig. 6-7

Saishree S. Iyer and Anna Akhmanova @utrechtuniversity.bsky.social review the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... #Centrioles #Cilia #Cytoskeleton

📣 New preprint from our lab! How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin? We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵 biorxiv.org/content/10.64898/2026.05.06.723191v1 1/7

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A/Prof Sam Stehbens PhD (She/Her)@samstehbens.bsky.social · 3mo ago

#microtubules in orange hot, #F-actin greyscale, Fibroblast, spinning disc. @marcoenriquez18.bsky.social @aibnatuq.bsky.social #fluorescenceFriday

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

A very nice study showing that there is no obvious relationship between tubulin compaction/expansion state and its nucleotide state. Indeed, there is no experimental data demonstrating that GTP-tubulin is expanded in the GTP-cap at microtubule growing ends.

cryoEM papers@cryoempapers.bsky.social · 4mo ago

Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state pubmed.ncbi.nlm.nih.gov/41951886/ #cryoEM

1/3 Lab #Preprint alert…A cool study led by @MullickSan22454 in collab with @ms_chirps lab showing how tubulin glycylation regulates ciliary motors and MAPs in vitro. @biorxiv_biochem. #glycylation #tubulinPTMs #cilia #Intraflagellartransport. Read more biorxiv.org/content/10.648…

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 4mo ago

Tubulin glycylation regulates microtubule-protein interactions that are key for ciliary stability and trafficking https://www.biorxiv.org/content/10.64898/2026.03.26.714406v1

New preprint out: arxiv.org/pdf/2604.01057 Together with JF Joanny and Sudipta, we introduce a "new" kind of active phase separation inspired by experiments with motors and microtubules and based on transport of species along a polar "pump"! @manuelthery.bsky.social @lblanchoin.bsky.social

🥳 Excited to share our #diatom work out in @pnas.org. In a great collaboration with @nic-poulsen.bsky.social and @ulrichschwarz.bsky.social we show that diatoms modulate the curvature of their paths by dynamic switching of their cell–substrate contact sites. doi.org/10.1073/pnas.2506122123

Cordula Reuther, Paula Santos-Otte, Stefan Diez and colleagues find that microtubule lattice defects facilitate spastin-mediated severing. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

🎉 Exciting news! Our paper has been accepted and is now published in Wiley Advanced Science! 🚀 Congratulations @bucklingmt.bsky.social Read it here: advanced.onlinelibrary.wiley.com/doi/epdf/10....

Happy to share that the study is now published in Advanced Science 🙌🥳 : advanced.onlinelibrary.wiley.com/doi/10.1002/... I want to thank my co-authors and my amazing PI @lauraschaedel.bsky.social for all the help, lovely discussions and encouragement😀

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

This study shows that kinesin-driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self-repair and leads to filament failure. While curvature, motor motility, and...

advanced.onlinelibrary.wiley.com

Shweta Nandakumar@bucklingmt.bsky.social · 11mo ago

Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9) www.biorxiv.org/content/10.1...

www.nature.com/articles/s41...

An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

Our new preprint is live!🎉 Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions. On bioRxiv now! Congrats @dyuthisreekumar.bsky.social www.biorxiv.org/content/10.6...

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Buzz Baum@buzzbaum.bsky.social · 6mo ago

Using micropatterning & thousands of hours on the microscope @manuelthery.bsky.social and the #CytoMorphoLab reimagined the Musée D’Orsay. Accompanied by an orchestra and poet, their images transported us into the cellular universe. I remembered why I am a cell biologist. All of this is in us. Wow!

Exciting new preprint from @schaedellab.bsky.social 🔬🧫 Vimentin network architecture and mechanics is mediated by cytosolic regulation. I can't help but marvel at the beautiful vimentin network images😍😍 I am so happy it's finally out😍😍❤️ Congratulations @dyuthisreekumar.bsky.social 👏🎉

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 7mo ago

Cytosolic factors govern vimentin network architecture and mechanics https://www.biorxiv.org/content/10.64898/2026.01.08.697713v1

Paclitaxel induces NM2-dependent cellular contraction independent of microtubule acetylation in live cells www.biorxiv.org/content/10.6...

Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read! Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase. www.biorxiv.org/content/10.6... Happy holidays ✨🎄

Now online! Structural basis of microtubule-mediated signal transduction

PhD Position in Biophysics #ScienceJobs #AcademicSky

PhD Position in Biophysics

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

📢Internships on cellular nematics! 🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis. 📧Feel free to DM or email me with any questions.

I like this movie, but a friend of mine likes to complain about the obvious stitching artifacts. I'll try harder next time, Michael. Vimentin (orange) and ER (blue) in an overnight acquisition.