Claudia Matthaeus
@cmatthaeus.bsky.social
Assistant Professor in Cellular Physiology of Nutrition @unipotsdam.bsky.social Interested in #caveolae , metabolism and #microscopy https://www.matthaeus-lab.de
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
💡New Preprint! How does a cell control which way a membrane bends? ESCRT-III has the remarkable ability to reshape membranes and drive reverse-topology fission, yet a fundamental question has remained: what determines the direction of membrane remodeling? www.biorxiv.org/content/10.6...
Direction of ESCRT-III-dependent membrane bending emerges from bilayer asymmetry
In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...
biorxiv.org
Identification of lipid specificity in membrane organizing protein complexes https://www.biorxiv.org/content/10.64898/2026.07.24.740489v1
Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
doi.org
How do liver cells determine whether lipids are stored or secreted? doi.org/10.1172/JCI2... Bo Wang & team report SEC16B helps manage lipids by balancing lipid release and storage—and its inhibition in mice lowers blood lipids and reduces atherosclerosis.
Online now: Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
(Cell Metabolism 37, 1–18.e1–e13; May 6, 2025)
dlvr.it
link.springer.com/article/10.1...
Tripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility - The EMBO Journal
Adipocyte dysfunction is a major driver of obesity-associated cardiometabolic disease, underscoring the need to understand how lipid storage and mobilization are regulated and disrupted. The ER-anchor...
link.springer.com
New preprint from the lab, led by the ever-talented grad student Tessa Lochetto @tlochetto.bsky.social! We find that loss of our favorite phosphatase Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/202... /1
Sustained loss of Pptc7 triggers variable skeletal muscle dysfunction and diminished body mass through dysregulation of BNIP3
The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...
doi.org
Save the date! Club Exocytose-Endocytose half-day scientific meeting is planned 📅 1 Dec 2026, 2 pm 📍 Centre Broca Nouvelle-Aquitaine, Bordeaux Neurocampus 🎤 ~8 talks 💻 Hybrid: in person or online Registration & abstract submission open in September. Stay tuned !!
Online now: Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity
Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity
The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients compete to be oxidized to meet systemic energy demands. Competitive catabolism normally produces homeostasis but, in obesity, converts increased lipolytic propensity into hyperglycemia and hyperinsulinemia.
dlvr.it
Analyzing large datasets is one of the messiest, most complicated parts of lipid research. So #HHMIInvestigator Tobias Walther's lab @mskcancercenter.bsky.social built LipidCruncher: a free, open-source, step-by-step platform that makes results easier to reproduce & share: bit.ly/3QWca0o.
Looking for your next step after a BS/BA or MS in biology, cell biology, biochemistry, or a related field? My NIH lab in Bethesda, MD is looking for a Lab Manager/Technical Specialist. Interested in basic research? Please email me directly or learn about our lab here: irp.nih.gov/pi/justin-ta...
Justin Taraska, Ph.D. | Principal Investigators | NIH Intramural Research Program
irp.nih.gov
RESEARCH | @alquierthierry.bsky.social @ejrideout.bsky.social et al.: Neuronal lipid droplet formation mediates energy homeostasis in a sex-specific manner in Drosophila and mice 🧪
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
dlvr.it
🚨🚨Last day to register for the next annual meeting of Club Exocytose-Endocytose !!!🚨🚨 Invited speakers: M. Stroeber, G. D'Angelo and @christlet.bsky.social 📍 Centre Paul-Langevin, Aussois, France 📅 May 27–29, 2026 Get ready for exciting science!! Registration here exoendo.org/evenement/28...
28ème congrès du Club Exo Endo - Aussois (Savoie)
Speakers invités: Giovanni D’Angelo (EPFL, Lausanne, Suisse) Christophe Leterrier (INP, Marseille, France) Miriam Stoeber (University of Geneva, Genève, Suisse)
exoendo.org
New perspective on caveolae www.nature.com/articles/s41...
A lipid-centric view of endocytosis by caveolae - Nature Cell Biology
This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.
nature.com
It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...
Dynamic GTPase networks reshaping endosomal organelle identities
Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…
sciencedirect.com
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
Interested in caveole and/or lipid metabolism? We have two master thesis projects available in the lab @unipotsdam.bsky.social starting September or October. For more details 👇 www.matthaeus-lab.de/post/04-2026...
04/2026 Master thesis projects available
We have two exciting master thesis projects available in the lab. Please see the announcements below. Start date is flexible, but earliest September or October 2026. If you are interested, please send...
matthaeus-lab.de
1/9 🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇 www.nature.com/articles/s42...
PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis - Nature Metabolism
Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...
nature.com
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...
Methods in Enzymology, Vols 726-728: Lipids & Membranes Vol 726: Detection by Imaging & Lipidomics www.sciencedirect.com/bookseries/m... Vol 727: Dynamics & Interorganelle Transport www.sciencedirect.com/bookseries/m... Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!
Methods in Enzymology | Volume 726: Lipids and Membranes: Detection by Imaging and Lipidomics | ScienceDirect.com by Elsevier
Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org
James Olzmann@olzmannlab.bsky.social · 5mo agoSooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...
Final week to apply: GSO Leadership Academy 10 The GSO Leadership Academy is an interactive program designed to support researchers who want to develop leadership skills for academia and beyond. 📅 Application deadline: March 1, 2026 🔗 More information: gsonet.org/foerderprogr...
Join us next Tuesday for the next @dgz.bsky.social workshop on #trafficking and EVs! Spread the word please!
Lipids challenge ligands to control receptors The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in. 🔗 buff.ly/G1Zl6cZ
Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -
Triglyceride/Cholesterol Ester Ratio Encodes Lipid Droplet Size and Diversity https://www.biorxiv.org/content/10.64898/2026.01.21.700800v1
Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳 www.nature.com/articles/s42...
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
nature.com
With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...
Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology
Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...
nature.com