Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...

A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

nature.com

New work from the lab! We report that DDIAS is a downstream effector of CIP2A-TOPBP1 in mitosis that suppresses ssDNA to preserve genome integrity. From the great @yiboxue.bsky.social and many collaborators! Free link: authors.elsevier.com/a/1nfiF3vVUP... Pay link: www.cell.com/molecular-ce...

Our latest work describing DDIAS as a new component of the TOPBP1-CIP2A pathway in mitosis and its requirement for brain development is now published. Fantastic collaboration with @fenaochs.bsky.social, @profstewartlab.bsky.social, Lars Allan Larsen, @tcr-miller.bsky.social, Zafar Iqbal & others

Cell - a Cell Press journal@cp-cell.bsky.social · 2mo ago

Now online! DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development

Very pleased to share this new study: In a truly collaborative effort with the lab of Pim Huis in 't Veld @huis.bsky.social, we combined biochemistry with cell biological and genomic approaches to uncover how CIP2A works in mitotic DNA repair. www.biorxiv.org/content/10.6...

CIP2A tetramerization is required for mitotic DNA repair

DNA lesions that persist in mitosis threaten genome stability. These lesions recruit TOPBP1-CIP2A, a complex crucial to tether and process damaged DNA on mitotic chromosomes. Importantly, CIP2A is syn...

biorxiv.org

mtDNA deletions cause incurable diseases. Our CRISPR screen found a fix: deleting MTERF1 restores mitochondrial function, not by clearing bad genomes, but by making the healthy ones work harder. Simple Biology! New preprint 👇 @tatakavlashvili.bsky.social www.biorxiv.org/content/10.6...

MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation

Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurable mitochondrial pathologies. Using a genome-wide C...

biorxiv.org

Our manuscript on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1 is finally out in @genesdev.bsky.social. Big thanks again to the Min, Lazzerini Denchi and @cejkalab.bsky.social labs! @angelotaglialatela.bsky.social genesdev.cshlp.org/content/earl...

Alberto Ciccia@albertociccia.bsky.social · 8mo ago

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Missed it? Our March preprint shows how endogenous oxidative base damage drives the PARPi response in ATM-deficient cells. In working this out we uncovered a role for ATM in safeguarding replication through damaged DNA and discuss what this could mean for Ataxia-Telangiectasia.

MRC Weatherall Institute of Molecular Medicine@imm.ox.ac.uk · 3mo ago

#WIMMReads🧪 From the Chapman Group: a new preprint offers a potential explanation for why ATM deficient cancers respond to PARP inhibitors, with implications for cancer treatment and Ataxia Telangiectasia. #CancerResearch #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk @rosschapmanlab.bsky.social 🧬

Happy to share our new review on 3D chromatin organisation by cohesin with you. It was a great pleasure to review recent advances and future prospects with @danielgerlich.bsky.social.

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 9mo ago

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

We are looking for a Postdoc to join us at the Center for Gene Expression @cgen2025.bsky.social at the University of Copenhagen! Full advertisement here: employment.ku.dk/faculty/?sho...

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine

employment.ku.dk

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Proteome-wide in silico screening for human protein-protein interactions

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

biorxiv.org

Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...

biorxiv.org

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Mitotic single-stranded DNA suppression by DDIAS

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

biorxiv.org

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

biorxiv.org

Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

By sucking up DNA, clot-producing platelets could help diagnose cancer

The cells could be a new source of tumor DNA for liquid biopsies

science.org

Lauren Murphy@l-cmurphy.bsky.social · last yr.

🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽 📖 Read our paper here: doi.org/10.1126/sci... 🎬 Watch a summary: youtu.be/MttCA3GGWEM 🧵 Or keep reading for the key points! 🔑 1/19

One week left to apply for the postdoc position in my lab at Oxford @ox.ac.uk Join our exciting cancer immunology research at @oncology.ox.ac.uk, @oxfordcancer.bsky.social & @oxcio.bsky.social. Deadline: 11 August 2025 (noon).

Jie Yang@jieyang437.bsky.social · last yr.

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

Lundbeckfonden@lundbeckfonden.bsky.social · last yr.

Stort tillykke til de nyligt udnævnte LF Fellows 2025! Vi er glade for at kunne tildele vores LF #Fellowship til syv yderst talentfulde forskere. Hver forsker modtager DKK 10 mio. til at støtte deres forskerprojekts udvikling over fem år. ow.ly/LKRh50VMYAP

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...

cell.com

Postdoctoral Fellow position available in the DDR Biology and Functional Genomics teams at AstraZeneca in Cambridge UK. Closing date: 30-Jan-2025 astrazeneca.wd3.myworkdayjobs.com/Emerging-Tal...

Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer

Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer The Discovery Centre, Cambridge Biomedical Campus, UK Competitive salary and benefits Introduction to role: Do you have expe...

astrazeneca.wd3.myworkdayjobs.com

Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.

Drew Berry wehi.tv@drewberry.bsky.social · 2y ago

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns. www.cell.com/trends/cell-...

Transcription-coupled repair of DNA–protein crosslinks

DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes...

cell.com

Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models. academic.oup.com/narcancer/ar...

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models

Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

academic.oup.com

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

Time for our first post here 🥳 Our latest paper is online 🙌 We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

cell.com

Really interesting and important deep dive into what all scientists kind-of-know but haven't quantified by @hansonmark.bsky.social @paolocrosetto.bsky.social @pagomba.bsky.social @danbrockington.bsky.social

Mark A. Hanson@hansonmark.bsky.social · 2y ago

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub

Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltex...

STK19 positions TFIIH for cell-free transcription-coupled DNA repair

Together with structural analyses, a cell-free system for transcription-coupled nucleotide excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex that couples RNA pol...

cell.com