Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...

Felix Campelo@felixmendu.bsky.social · 11mo ago

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair

Nature Communications - Not all components of the lysosome damage response pathway have been defined. Here, the authors discover that the bridge-like lipid transport protein VPS13C senses lysosomal...

rdcu.be

Evidence suggests that AI-driven ‘deskilling’ is starting to happen in medicine, computer science and other fields go.nature.com/4vtwEN1

Is AI ruining our skills? Early results are in — and they’re not good

Reliance on artificial-intelligence tools degrades the abilities of physicians and software engineers, studies show.

go.nature.com

Three PhD positions available to work on yeast lysosome biogenesis and reconstitution of membrane fusion as of July or September 2026. Details can be found here: myshare.uni-osnabrueck.de/f/76c16d1fcc...

260508_PhD positions available.pdf

Share link for 260508_PhD positions available.pdf.

myshare.uni-osnabrueck.de

It's finally out! Molecular architecture of mammalian AP3:ARF1 carriers - a mechanism for lysosomal membrane protein trafficking - from a combination of #biochemistry, #cryoET and #cellbiology 📝 Paper: www.science.org/doi/10.1126/... 🧵 Thread: subsequently #teamtomo #membranetrafficking

Briggs Group@briggsgroup.bsky.social · 3mo ago

The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social

#membrane seminars are back this week with @javierespadas.bsky.social from the @rouxlab.bsky.social and Chris Burd from @yalecellbiology.bsky.social! Looking forward to seeing everyone online!

Amazing find by @oliverrocks.bsky.social and @pm-mueller.bsky.social , such a cool discovery. Was fun to be involved.

Oliver Rocks@oliverrocks.bsky.social · 4mo ago

Check out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

I am very happy that the last bit of my doctorial work has reached the stage to be presented in the form of a preprint! Here we have a look at GGAs and how they might be connected to AP-1 transport. If you enjoy Golgi-endosome transport, please have a look; www.biorxiv.org/content/10.6...

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 5mo ago

A general role for GGA adaptors in the modulation of AP-1-dependent trafficking https://www.biorxiv.org/content/10.64898/2026.03.25.714221v1

A wonderful collection of contemporary topics and perspectives on secretion and Golgi biology edited by Akihiko Nakano and Jaakko Saraste. The Golgi Network, Volume II @SN and link.springer.com/book/10.1007...

The Golgi Network, Volume II

This book explores the interaction of Golgi with different organelles such as ER, the vesicular system, and protein complexes that execute these tasks.

link.springer.com

New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1. www.biorxiv.org/content/bior...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

mStayRose is published in JBC 🥳🎉 Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable: www.jbc.org/article/S002...

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion

Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric green fluorescent protein recently monomerised through sequence engi...

jbc.org

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant - MCDB - UOD2016

Closing date: Thursday 6 November 2025, 23:59

dundee.ac.uk

👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging: www.biorxiv.org/content/10.1... Congratulations to Julian Kompa and the entire team.

Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging

We present Rho-tag and SiR-tag, engineered protein tags derived from bacterial multidrug-resistance proteins that bind unsubstituted (silicon-) rhodamines with nanomolar affinity, enabling fast, rever...

biorxiv.org

journals.biologists.com/jcs/article/... "Until I started my PhD, I played guitar in an all-girl punk rock band. We played gigs around Milan, and there are still some videos floating around on YouTube (no, I won't tell you the band name!)" We definitely picked the right JCS 2026 meeting organiser!

Cell scientist to watch – Francesca Bottanelli

ABSTRACT. Francesca Bottanelli is an Assistant Professor in the Department of Biochemistry at Freie Universität Berlin (Germany). Francesca graduated in Plant Biotechnology from the University of Mila...

journals.biologists.com

Finally! (remember the famous 2022 ASCB poster and Twitter discussion) www.biorxiv.org/content/10.1...

Enhanced axonal transport in large vertebrates: KIF5A adaptations in giraffes and pythons

Efficient axonal transport is essential for neuronal function, particularly in species with exceptionally long axons. The Kinesin-1 motor protein KIF5A plays a key role in this process, but whether an...

biorxiv.org

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/... #Membrane #lipid #Organelles #Biochemistry

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Love #lipids and #membranes??? Then you cannot miss these seminars tomorrow with two amazing rising ⭐️ ⭐️ @abelljonny.bsky.social @ibudin.bsky.social

Ishier Raote@ishier.bsky.social · 2y ago

Two exciting #MembraneSeminars this week! Thu, 5 Dec 5.00 PM CET / 11.00 AM EST Jonathon Nixon-Abell (CIMR, Univ. Cambridge, UK) Protein-lipid phase coupling in lysosomal transport Itay Budin (UCSD, CA, USA) New tools for visualizing lipid trafficking between and across organelle membranes