Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
Christophe Le Clainche
@actin-paris-saclay.bsky.social
Actin cytoskeleton-associated machines that produce and sense force in adhesion and migration. CNRS researcher, Group leader, Head of Cell Bio dept at https://www.i2bc.paris-saclay.fr https://scholar.google.fr/citations?user=tOHuSNMAAAAJ&hl=fr
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...
Myosin forces remodel F-actin for mechanosensitive protein recognition - Nature
Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica...
nature.com
Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs...
Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs...
I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026
I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026
✍️The @bladoux.bsky.social / @rmmege.bsky.social Lab contributed to a new publication 📖 @science.org Advances 📃 Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization 🔗 www.science.org/doi/10.1126/...
New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
#HappyNewYear ! Let's start 2026 with a @cellcommlab.bsky.social paper How many branches is OK during #CellMigration? It depends on the #cell: for ex. immune cells are just fine. In collab. w. #NirGov @hfspo.bsky.social Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬
New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
Open FSEP position in our team 📣 Nous recrutons un/e Ingénieur/e d’étude en biologie. Profil : être titulaire d’un poste permanent au CNRS (IE) et avoir envie d’étudier la chromatine bactérienne 😉 Date limite : jeudi 15 janvier. Détails et candidature ici : mobiliteinterne.cnrs.fr/ords/afip/ow...
Détails de la fonction choisie
mobiliteinterne.cnrs.fr
We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo...
This week we are celebrating the 10th anniversary of the I2BC — very proud of what we have accomplished together! www.i2bc.paris-saclay.fr
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link: emploi.cnrs.fr/Offres/Docto...
Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru...
Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...
Genetically encoded reporters of actin filament organization in living cells and tissues
Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...
cell.com
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social @cnrsbiologie.bsky.social cnrs physique @anr
Comment les macrophages sont influencés par leur environnement ? 🧐 Une récente étude menée par @florenceniedergang.bsky.social révèle que leur interaction avec leur milieu joue un rôle clé dans leur activité immunitaire !
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article 📖 Nature materials 📃 Force transmission is a master regulator of mechanical cell competition 🔗 www.nature.com/articles/s41...
Force transmission is a master regulator of mechanical cell competition - Nature Materials
Differences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication...
nature.com
What happens between cells with adhesion differences in crowded tissues? Mechanical cell competition! Check the final version of our study to learn more about compression-independent cell elimination, interactions at tissue interfaces and the role of force transmission in that tinyurl.com/4yw97bm3
Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Our new #Mechanobiology collection examines the mechanical properties & interactions that shape the fundamental operations & structures of cells. Delve into diverse mechanical properties of membranes, organelles & other structures within & among cells 👉 https://buff.ly/3EK0uaq
Congratulations to all ! Very happy to have been part of this collaboration !
our lastest publication on #macrophages and #phagocytosis @institutcochin.bsky.social is out! thanks to @manondepierre.bsky.social and Anna Mularski in colaboration with @actin-paris-saclay.bsky.social and Martial Balland @ugrenoblealpes.bsky.social
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !
Don't miss the opportunity to come and work with us, as this is the last week to apply for our cell biology group leader position. Application deadline: Feb 28, 2025
The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social
Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. @cp-cellreports.bsky.social www.cell.com/cell-reports...
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward
The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social
Our collaboration with the Germain Lab is now out in its final form!
📣 I’m looking for PhD students to work at the intersection of theoretical physics & biology -topics range from active cell mechanics to collective cell migration & tissue patterning! Feel free to reach out for more info (DM/email)! Please repost / share 🙂