Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome - Nature

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

nature.com

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Cell membranes sustain phospholipid imbalance via cholesterol asymmetry

This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...

cell.com

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation

Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...

science.org

The GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriers

The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083

biorxiv.org

In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment

Lyubetskaya et al. create a spatial map of untreated primary pancreatic cancer through integration of spatial gene expression profiling, histology characterization, pathology annotation, and machine vision. The map reveals the spectrum of benign, neoplastic, and classical-to-basal tumor cells present within every patient, uncovering their unique regulators and microenvironments.

dlvr.it

CELL MIGRATION LAB

We study cell migration in health and disease

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2026 Signaling by Adhesion Receptors Conference GRC

The 2026 Gordon Research Conference on Signaling by Adhesion Receptors will be held in Manchester, New Hampshire. Apply today to reserve your spot.

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KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism - preLights

KANK2 plays a dual role – dictating cells when to move and when to stick!

prelights.biologists.com

Ex Vivo Assay for Organ-Specific Cancer Cell Invasion

Metastasis is the leading cause of cancer-related mortality, yet experimental models inadequately recapitulate the tissue-specific microenvironments that shape metastatic dissemination. In vivo system...

biorxiv.org

Cellular and molecular aspects of mechanobiology of the extracellular matrix

sciencedirect.com

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal

The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

link.springer.com

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

Summary: The key adhesion protein focal adhesion kinase (FAK) transduces adhesion signals to enhance glycolysis and oxidative phosphorylation in a glioblastoma stem-cell model, highlighting a…

doi.org

Talin force coupling underlies eukaryotic cell-substrate adhesion - Nature Communications

Talin is a well-known regulator of cell adhesion and intracellular force transmission in animals. Here, the authors demonstrate that talin’s mechanical function is evolutionarily conserved and already established in unicellular eukaryotes.

nature.com

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway | Journal of Cell Biology | Rockefeller University Press

The study reveals that newly synthesized integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance ce

doi.org

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

cell.com

Mechanochemical waves in focal adhesions during cell migration

Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.

science.org