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David Cortez

@dkcortez.bsky.social

Professor and Chair, Department of Biochemistry

7 Posts249 Follower150 Folgt
Joshua Weitz@joshuasweitz.bsky.social · 2w ago

The NIH proposal to conceal reviewer scores from program officers, investigators, and advisory councils is ill-conceived, introduces disproportionate weight to small percentile differences, diminishes the role of scientific peer review, and should be withdrawn in its entirety. a 🧵

What is NIH Leadership Trying to Hide from Researchers & the Public?

A NIH proposal to conceal reviewer rankings of investigator-initiated research grants is ripe for misuse & demands a collective response (by October 13).

joshuasweitz.substack.com

Ardem Patapoutian@ardemp.bskyverified.social · 2mo ago

NIH's Aug 2026 proposal would scrap exact scores and percentiles for three broad bins (top = top 25%). With funding rates at 5% or lower, too much then rides on administrative discretion. It devalues peer review and is a deterrent to engage. Tell NIH before Oct 13. grants.nih.gov/grants/guide...

NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH

grants.nih.gov

Alberto Ciccia@albertociccia.bsky.social · 6mo ago

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

annualreviews.org

Basil Greber@bjgreber.bsky.social · 6mo ago

It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!

Basil Greber@bjgreber.bsky.social · 6mo ago

It is almost over, so this seems to be a good time to share a few photos taken during the DNA repair meeting in Egmond aan Zee (mostly in the early mornings before sessions). What a fantastic setting to hold a conference!

A panel of 9 images taken in Egmond aan Zee (NL). They include three views of the local lighthouse at sunrise and after sunset, one photo of a very woolly cow amongst green bushes, a seal at the beach, and four panels showing local birds capture in their environment.
Vanderbilt School of Medicine Basic Sciences@vubasicsciences.bsky.social · 6mo ago

🎉 Congratulations to Steven Fesik and Neil Osheroff, who have been honored with 2026 awards from The Protein Society. Learn more about their prestigious awards 👉 www.proteinsociety.org/protein-soci...

Protein Society Awards

TPS awards recognize excellence across the diverse disciplines that collectively advance our understanding of proteins; their structure, function, design, and application. The Awards honor…

proteinsociety.org

Chowdhury Lab@chowdhurylab.bsky.social · 6mo ago

Out today in @cp-molcell.bsky.social! We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping. Congratulations to first author Kaimeng Huang, all co-authors and collaborators. www.sciencedirect.com/science/arti...

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…

sciencedirect.com

Vincenzo Costanzo@labvincenzo.bsky.social · 7mo ago

Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy. #DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​ www.cell.com/molecular-ce...

Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy

Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

cell.com

Chris Carnie@cjcarnie.bsky.social · 10mo ago

Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.

EMBO Molecular Medicine@embomolmed.org · 10mo ago

Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social 🗞️ doi.org/10.1038/s443...

Lopes_Lab@lopeslab.bsky.social · 10mo ago

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

rdcu.be

Ernst Schmid@ernstschmid.bsky.social · 12mo ago

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Proteome-wide in silico screening for human protein-protein interactions

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

biorxiv.org

Arnab Ray Chaudhuri@raychaudhurilab.bsky.social · 12mo ago

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments

Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...

science.org

David Cortez@dkcortez.bsky.social · last yr.

Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences nam04.safelinks.protection.outlook.com?url=https%3A...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515

Department of Biochemistry, School of Medicine—Basic Sciences

nam04.safelinks.protection.outlook.com

Vanderbilt School of Medicine Basic Sciences@vubasicsciences.bsky.social · last yr.

🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic. Learn more 👉 medschool.vanderbilt.edu/basic-scienc...

Vanderbilt research looks to smooth out bumps in medicinal chemistry processes

Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

medschool.vanderbilt.edu

JStark lab@jstarklab.bsky.social · last yr.

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

Postdoctoral Training Programs

Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

imgs-coh.edu

Rosado lab@rosadolab.bsky.social · 2y ago

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

science.org

Kavi Mehta@k4v1.bsky.social · 2y ago

Very proud of this. It’s both the end and beginning of something new for me. My last paper in @dkcortez.bsky.social lab and my first co-corresponding author. Also truly a great supergroup including @freudlab.bsky.social @tmweaver.bsky.social and Roberts lab www.nature.com/articles/s41...

Contributing factors to the oxidation-induced mutational landscape in human cells - Nature Communications

8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...

nature.com